“Benefits of Antimicrobial Photodynamic Therapy as an Adjunct to Non-Surgical Periodontal Treatment in Smokers with Periodontitis: A Systematic Review and Meta-Analysis“
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Fecha
2023-03-30Autor(es)
Villafuerte, Kelly R. V.
Martinez, Cristhiam Jesus H.
Palucci Vieira, Luiz H.
Nobre, Atila V.
Metadatos
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“The objective of this study was to analyze evidence of the clinical and microbiological benefits
of antimicrobial photodynamic therapy (aPDT) adjunctive to scaling and root planing (SRP) in smokers
with periodontitis. Randomized clinical trials (RCTs) were included, through an electronic search in
PubMed/MEDLINE, LILACS, Web of Science, and the Cochrane Library for articles published in English
until December 2022. The quality of the studies was assessed using the JADAD scale and the risk of
bias was estimated using the Cochrane Collaboration assessment tool. Of the 175 relevant articles, eight
RCTs were included. Of these, seven reported clinical results and five microbiological results, with a
follow-up time of 3–6 months. A meta-analysis was performed for the probing depth (PD) reduction and
clinical attachment level (CAL) gain at 3 and 6 months. The weighted mean differences (WMDs) and
95% confidence intervals (CIs) were counted for the PD and CAL. The overall effect for the PD reduction
at 3 and 6 months (WMD = −0.80, 95% CI = −1.44 to −0.17, p = 0.01; WMD = −1.35, 95% CI = −2.23
to −0.46, p = 0.003) was in favor of aPDT. The CAL gain (WMD = 0.79, 95% CI = −1.24 to −0.35,
p = 0.0005) was statistically significant at 6 months, in favor of aPDT. In these RCTs, aPDT was unable
to demonstrate efficacy in reducing the microbial species associated with periodontitis. aPDT as an
adjuvant to SRP improves the PD reduction and CAL gain more effectively than only SRP. RCTs are
needed to establish standardized protocols with longer follow-up times in order to provide more results
on aPDT adjunctive to SRP in smokers with periodontitis.“
Colecciones
- SCOPUS [380]