“Relationship between Butyrylcholinesterase Activity and Cognitive Ability in Workers Exposed to Chlorpyrifos“
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Fecha
2023-03-01Autor(es)
Rosales-Rimache, Jaime
Machado-Pereyra, Paola
Bendezu-Quispe, Guido
Metadatos
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“Background. The use of Chlorpyrifos leads to a public, environmental, and occupational
health problem associated with adverse effects in the exposed population, generating alterations
mainly in the central nervous system, such as cognitive function. This study aimed to estimate the
association between butyrylcholinesterase activity (BChE) and cognitive ability in workers exposed
to chlorpyrifos. Methods. We designed a cross-sectional study, where we measured BChE in serum
samples as an indicator of exposure to chlorpyrifos. The cognitive ability was assessed by the
mean score of the Peruvian version of the Mini-Mental State Examination (MMSE). We also used a
questionary to collect demographic and occupational information. Results. We evaluated 120 farmers
with a predominance of males (92%) and a mean age of 32.1 ± 9.0 years. We found most of the
workers in fumigation activities (84%). The mean BChE was 6144.7 ± 2355.0 U/L, and 46% presented
inhibition enzyme (<5500 U/L). The median MMSE score was 28 (interquartile range: 26.5–31.5; 6%
showed an alteration in cognitive ability (score < 24)). The MMSE test found a significant association
between BChE inhibition and MMSE score (β: −0.071, 95%CI: −0.108 to −0.025). Conclusion. In this
study, 45.8% of workers exposed to chlorpyriphos presented BChE inhibition. The BChE inhibition is
significantly associated with the MMSE score in workers exposed to chlorpyrifos.“
Colecciones
- Web of Science (WOS) [236]