Antigen-Induced IL-1RA Production Discriminates Active and Latent Tuberculosis Infection
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Fecha
2023-05-25Autor(es)
Sanchez, Cesar
Jaramillo-Valverde, Luis
Capristano, Silvia
Solis, Gilmer
Soto, Alonso
Valdivia-Silva, Julio
Poterico, Julio A.
Guio, Heinner
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“The IGRA (Interferon Gamma Release Assays) test is currently the standard specific test
for Mycobacterium tuberculosis infection status. However, a positive test cannot distinguish between
active tuberculosis disease (ATBD) and latent tuberculosis infection (LTBI). Developing a test with
this characteristic is needed. We conducted longitudinal studies to identify a combination of antigen
peptides and cytokines to discriminate between ATBD and LTBI. We studied 54 patients with ATBD
disease and 51 with LTBI infection. Cell culture supernatant from cells stimulated with overlapping
Mycobacterium tuberculosis novel peptides and 40 cytokines/chemokines were analyzed using the
Luminex technology. To summarize longitudinal measurements of analyte levels, we calculated
the area under the curve (AUC). Our results indicate that in vitro cell stimulation with a novel
combination of peptides (Rv0849-12, Rv2031c-14, Rv2031c-5, and Rv2693-06) and IL-1RA detection in
culture supernatants can discriminate between LTBI and ATBD.
“
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