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dc.contributor.authorMoya-Salazar, Jeeles_ES
dc.contributor.authorCerda, Sandra P.es_ES
dc.contributor.authorCañari, Betsyes_ES
dc.contributor.authorMoya-Salazar, Marcia M.es_ES
dc.contributor.authorContreras-Pulache, Hanses_ES
dc.date.accessioned2022-11-24T21:10:05Z
dc.date.available2022-11-24T21:10:05Z
dc.date.issued2022-09-01
dc.identifier.urihttps://hdl.handle.net/20.500.13053/7241
dc.description.abstractThe female hormonal profile is of utmost importance for the assessment of the endocrinological functional status and the diagnosis of diseases. The analysis must delimit their normality intervals based on the manufacturer's cut-off points. Due to not all intervals can be evaluated before use, it is imperative to verify the reference intervals to achieve uniformity in the interpretation of results in the female population. We determine the reference intervals of five female sex hormones [Follicle Stimulating hormone (FSH), Estradiol, Luteinizing Hormone (LH), Prolactin, and progesterone] using electrochemiluminescence in the Cobas e411 (Roche). We included female patients >18 years old, between the 3rd and 15th day of the menstrual cycle (follicular phase) and had no previous medical history or recent medication. For reference intervals analysis, we followed the recommendations of the CLSI C28-A3 guideline. The average concentration for FSH, progesterone, LH, prolactin and estradiol were 11.48 ± 21.10 mIU/ml, 8.19 ± 11.90 ng/ml, 10.98 ± 11.55 ng/ml, 25.05 ± 32.74 ng/mL, and 147.08 ± 473.8 pmol/mL, respectively. Eighty per cent of parameters showed a satisfactory transfer for the manufacturer's reference intervals, except for estradiol, which had 85.5% of transferred values. Our results suggest that 4/5 sex hormones were found within the manufacturer's reference intervals and can be quantified in Peruvian women, ensuring the quality of their results. However, it is necessary to determine the estradiol with other reagents and assays since we show errors in the transfer of intervals.es_ES
dc.formatapplication/pdfes_ES
dc.language.isoenges_ES
dc.publisherElsevier Ltdes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subject"Reference intervals Sex hormones Lutein hormone Progesterone Estrogen Folic stimulant hormone Prolactin Chemiluminescence Peru"es_ES
dc.titleReference intervals of the sex hormonal profile in healthy women: A retrospective single-center study in Perues_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.identifier.doihttps://doi.org/10.1016/j.heliyon.2022.e10592es_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersiones_ES
dc.publisher.countryNLes_ES
dc.subject.ocdehttp://purl.org/pe-repo/ocde/ford#3.03.00es_ES


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