Mahmudiono, TriasKhaydarov, Nodirjon KadirovichJasim, Saade AbdalkareemHammid, Ali ThaeerFailoc-Rojas, Virgilio E.Shalaby, Mohammed NaderMehranNouri, Behrooz JannatgAbdulmnannan Fadel j2022-10-242022-10-242022-07-07https://hdl.handle.net/20.500.13053/6922“ackground and aims: Our aim in this meta-analysis was to determine the effect of soy and soy product supplementation on serum adiponectin levels. Method: A systematic search was conducted using Medline (PubMed and Web of Science), Scopus, and Cochrane Library for eligible trials up to August 2020. A random-effects model was used to pool calculated effect sizes. Results: Seven trials were included in the overall analysis. Our analysis showed that soy and soy product supplementation did not significantly affect adiponectin concentrations (WMD ¼ 0.77 mg/ml, 95% CI: 0.61, 2.15, P ¼ 0.27) in comparison with a placebo. The between-study heterogeneity was high (I2: 68.2%, P ¼ 0.004). Subgroup analysis, based on participants’ health status and duration of the supple- mentation, could not detect the potential source of the observed heterogeneity. In addition, subgroup analysis showed that the effect was not statistically significant in all subgroups. Conclusion: Overall, soy and soy product supplementation did not change the circulatory adiponectin levels. In addition, the results were not affected by the participant's health status and duration of sup- plementation. However, further studies are needed to confirm the present results“application/pdfenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/4.0/Soy, Adipokines Adiponectin, Systematic review, Meta-analysisinfo:eu-repo/semantics/articlehttps://doi.org/10.1016/j.dsx.2022.102558http://purl.org/pe-repo/ocde/ford#3.03.00