Paz-Ibarra, JoseLu-Antara, JoseUscamayta, Brenda-ErendidaMartinez-Auris, JhancyValencia-Rivera, MiriamSáenz-Bustamante, SofíaDelgado-Rojas, MarialejandraSalcedo-Vasquez, JuliaConcepción-Zavaleta, Marcio2023-09-112023-09-112023-04https://hdl.handle.net/20.500.13053/9303“Doege–Potter syndrome (DPS) is a paraneoplastic syndrome characterized by nonislet cell tumor hypoglycemia due to a solitary fibrous tumor, which produces insulin-like growth factor II. In this report, we present the case of a 67-year-old male with recurrent and refractory hypoglycemia due to DPS successfully treated with imatinib. He initially presented with neuroglycopenic symptoms and dyspnea secondary to a giant tumor in the left hemithorax, which was totally resected. During follow-up, 7 years later, he presented with thoracoabdominal tumor recurrence associated with severe hypoglycemia and underwent subtotal tumor resection, with a subsequent improvement of symptoms. The following year, he had a recurrence of his intra-abdominal tumor, which was unresectable, associated with severe hypoglycemia refractory to dextrose infusion and corticosteroids, thus receiving imatinib with a favorable response. The clinical presentation, diagnostic approach, progression of the disease, and response to treatment with imatinib in the management of a patient with large, recurrent, and unresectable mesenchymal tumors with insulin-like growth factor-2 secretion causing hypoglycemia highlight the importance of this case report“application/pdfenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/4.0/Doege–Potter, Solitary fibrous tumorinfo:eu-repo/semantics/article10.1530/EDM-22-03603.03.00 -- Ciencias de la salud