Champa Guevara, César AlfonsoLeguia Gutierrez, Judith Rosemery2026-01-152026-01-152025-12-03https://hdl.handle.net/20.500.13053/15221Introducción: Los sistemas de salud se transformaron en la pandemia COVID-19, causando cambios que afectaron la vigilancia de infecciones bacterianas y fúngicas en todo el mundo. En ese sentido, muchas especies pueden haber cambiado su epidemiologia. Nuestro objetivo fue determinar las variaciones anuales y perfil de resistencia de cepas fúngicas aisladas a partir de muestras clínicas recolectadas en el periodo previo a la pandemia de COVID-19 y durante el tiempo que esta se desarrolló en el Hospital de EsSalud en la ciudad de Abancay-Apurímac entre el 2018 al 2023. Metodología: Es un analisis observacional retrospectivo donde se analizaron 4610 muestras clínicas referidas para cultivo fúngico del Servicio de Microbiología. Fueron incluidos resultados de pacientes de ambos sexos, con infecciones superficiales/sistémicas y con registro en el sistema de reportes del hospital. Los datos se analizaron mediante registros físicos/digitales (CIE-10), se estandarizaron en Excel y analizaron con SPSS v24. Resultados: Del total se identificaron 226 (4.9%) cultivos positivos. La positividad pre-pandemia (2018–2019) fue 13.3% (43/303), reduciéndose a 1.3–1.8% en 2020–2021, post-pandemia (20.4–47.8% en 2022–2023) registrándose una variación significativa entre periodos del estudio (p=0.011). Entre 2018–2019, Trichophyton mentagrophytes (21.4%), Trichophyton tonsurans (30.4%) el más frecuente, mientras que entre 2020–2021, predominó Candida sp. (33.3–100%). Entre 2022–2023, Trichophyton tonsurans (26.1–39.8%) e informes no específicos de "hifas y levaduras" (29.6%) fueron los más frecuentes. No se registraron datos de resistencia antifúngica. Conclusiones: Se evidenció variaciones anuales en la resistencia fúngicas aisladas, las cuales se manifestaron al comparar los aislamientos obtenidos en el periodo previo a la pandemia por COVID-19.Introduction: Healthcare systems underwent a transformation during the COVID-19 pandemic, causing changes that will impact the surveillance of bacterial and fungal infections worldwide. In this regard, many species may have undergone a change in their epidemiology. Our objective was to determine the annual variations and resistance profile of fungal strains that were studied from clinical samples collected prior to the COVID-19 pandemic and during its duration the EsSalud Hospital Abancay-Apurímac, between 2018 and 2023. Methodology: This was a retrospective observational study in which 4,610 clinical samples referred for fungal culture by the Microbiology Service were analyzed. Results included patients of both sexes, with superficial and/or systemic infections, and with records in the hospital’s reporting system. Data were obtained from physical and digital records (ICD-10), standardized in Excel, and analyzed using SPSS v24. Results: Out of the total samples, 226 (4.9%) tested positive. The positivity rate before the pandemic (2018–2019) was 13.3% (43/303), decreasing to 1.3–1.8% in 2020–2021. In the post-pandemic period (2022–2023), the rate increased significantly (20.4–47.8%), showing a marked variation across study periods (p = 0.011). During 2018–2019, Trichophyton mentagrophytes (21.4%) and Trichophyton tonsurans (30.4%) were the most frequent. In 2020–2021, Candida sp. predominated (33.3 100%). In 2022–2023, Trichophyton tonsurans (26.1–39.8%) and nonspecific reports of “hyphae and yeasts” (29.6%) were the most common. No antifungal resistance data were recorded. Conclusions: Annual variations were observed in fungal isolates, which became evident when comparing the isolates obtained in the period prior to the COVID 19 pandemic with those recorded during it.application/pdfspainfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/MicosisMycosesCandidaCandidaCryptococcusCryptococcusCOVID-19COVID-19AntifúngicosAntifungal Agentsinfo:eu-repo/semantics/bachelorThesishttps://purl.org/pe-repo/ocde/ford#2.06.02https://purl.org/pe-repo/ocde/ford#3.01.09https://purl.org/pe-repo/ocde/ford#3.04.02ODS 3: Salud y bienestar. Garantizar una vida sana y promover el bienestar de todos a todas las edades