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dc.contributor.authorMoya‐Salaza, Jeel
dc.contributor.authorCóndor, Liliana Y.
dc.contributor.authorZuñiga, Nahomi
dc.contributor.authorJaime‐Quispe, Alexis
dc.contributor.authorCañari, Betsy
dc.contributor.authorContreras‐Pulache, Hans
dc.date.accessioned2023-08-03T15:03:51Z
dc.date.available2023-08-03T15:03:51Z
dc.date.issued2023-01-30
dc.identifier.urihttps://hdl.handle.net/20.500.13053/9108
dc.description.abstractBackground and Aims:COVID‐19 is a pandemic disease that can lead to alteredlung function, systemic inflammatory events, and altered coagulation. During severestages of the disease, changes in coagulation homeostasis increase, leading tothrombosis, and increased risk of death. In this cross‐sectional study, we aimedto assess coagulation markers by COVID‐19 severity in Peruvian adults.Methods:During the second wave of infections, we included 186 adults diagnosedwith COVID‐19 (mean age 53.3 ± 16.3 years). Patients were divided into mild,moderate, and severe stages of COVID‐19, and coagulation markers includedprothrombin time (PT), activated partial prothrombin time (aPTT), fibrinogen,D‐dimer, and platelet count.Results:Of the total, 120 (64.5%) were males and 39 (21%) were in the intensivecare unit. We determine 104 (55.9%), 43 (24.7%), and 36 (19.4%) patients in mild,moderate, and severe stages of COVID‐19, respectively. In the severe stage ofCOVID‐19, patients had an average concentration of PT, aPTT, fibrinogen,D‐dimer,and platelets of 13.2 ± 0.9 s, 28.9 ± 4.3 s, 679.4 ± 185.1 mg/dL, 1.9 ± 3.1 μg/mL, and272.8 ± 88.9 cel/10 mm,3respectively. We found no differences in the concentra-tion of each marker according to severity (p< 0.05). Patients with severe COVID‐19had altered the aPTT, fibrinogen,D‐dimer, and PT in 31 (57.4%), 48 (88.9%), 37(68.5%), and 15 (27.8%) cases, respectively.Conclusions:Our results showed that although there is an alteration in coagulationmarkers, mainly fibrinogen andD‐fiber, there are no differences in concentrationaccording to the severity of COVID‐19.es_PE
dc.formatapplication/pdfes_PE
dc.language.isoenges_PE
dc.publisherJohn Wiley and Sons Inces_PE
dc.rightsinfo:eu-repo/semantics/openAccesses_PE
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/es_PE
dc.subjectcoagulation, COVID‐19, D dimer, fibrinogen, prothrombin time, SARS‐CoV‐2es_PE
dc.titleAlterations in the coagulation markers did not showdifferences with the severity of COVID‐19 in Peruvianpatients: A cross‐sectional single‐center studyes_PE
dc.typeinfo:eu-repo/semantics/articlees_PE
dc.identifier.doi10.1002/hsr2.1105
dc.type.versioninfo:eu-repo/semantics/publishedVersiones_PE
dc.publisher.countryNLes_PE
dc.subject.ocde3.00.00 -- Ciencias médicas, Ciencias de la saludes_PE


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