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dc.contributor.authorSanchez, Cesar
dc.contributor.authorJaramillo-Valverde, Luis
dc.contributor.authorCapristano, Silvia
dc.contributor.authorSolis, Gilmer
dc.contributor.authorSoto, Alonso
dc.contributor.authorValdivia-Silva, Julio
dc.contributor.authorPoterico, Julio A.
dc.contributor.authorGuio, Heinner
dc.date.accessioned2023-10-10T18:40:20Z
dc.date.available2023-10-10T18:40:20Z
dc.date.issued2023-05-25
dc.identifier.urihttps://hdl.handle.net/20.500.13053/9526
dc.description.abstractThe IGRA (Interferon Gamma Release Assays) test is currently the standard specific test for Mycobacterium tuberculosis infection status. However, a positive test cannot distinguish between active tuberculosis disease (ATBD) and latent tuberculosis infection (LTBI). Developing a test with this characteristic is needed. We conducted longitudinal studies to identify a combination of antigen peptides and cytokines to discriminate between ATBD and LTBI. We studied 54 patients with ATBD disease and 51 with LTBI infection. Cell culture supernatant from cells stimulated with overlapping Mycobacterium tuberculosis novel peptides and 40 cytokines/chemokines were analyzed using the Luminex technology. To summarize longitudinal measurements of analyte levels, we calculated the area under the curve (AUC). Our results indicate that in vitro cell stimulation with a novel combination of peptides (Rv0849-12, Rv2031c-14, Rv2031c-5, and Rv2693-06) and IL-1RA detection in culture supernatants can discriminate between LTBI and ATBD.es_PE
dc.formatapplication/pdfes_PE
dc.language.isoenges_PE
dc.publisherMDPIes_PE
dc.rightsinfo:eu-repo/semantics/openAccesses_PE
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/es_PE
dc.subjectMycobacterium tuberculosis; biomarkers; active tuberculosis; latent tuberculosis; immune response; IL-1RAes_PE
dc.titleAntigen-Induced IL-1RA Production Discriminates Active and Latent Tuberculosis Infectiones_PE
dc.typeinfo:eu-repo/semantics/articlees_PE
dc.identifier.doi10.3390/microorganisms11061385
dc.type.versioninfo:eu-repo/semantics/publishedVersiones_PE
dc.publisher.countryCHEes_PE
dc.subject.ocde3.03.00 -- Ciencias de la saludes_PE


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