Farmacia y Bioquímica

URI permanente para esta comunidadhttps://hdl.handle.net/20.500.13053/33

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Examinando Farmacia y Bioquímica por Autor "Abarca Vega, Erika Victoria"

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    Actividad antiulcerosa del extracto etanólico de las hojas de Ficus carica L. "Higo" en ratas
    (Universidad Privada Norbert Wiener, 2018-09-17) Abarca Vega, Erika Victoria; Chávez Flores, Juana Elvira
    Objective: To determine the antiulcer activity of the ethanolic extract of Ficus carica L. (“Fig”) leaves in rats. An ethanolic maceration of the plant leaves was carried out, followed by solubility testing, preliminary phytochemical analysis, and evaluation of antiulcer activity using the modified Lee (1971) technique at doses of 300, 600, and 800 mg/kg. A total of 60 Holtzman rats were randomly distributed into six groups, induced with gastric ulcer using naproxen 200 mg/kg, with ranitidine 30 mg/kg as the reference drug. The extract was shown to be soluble in methanol, ethanol, and distilled water. The preliminary phytochemical screening revealed the presence of flavonoids, alkaloids, phenolic compounds, and free amino groups. Regarding the antiulcer activity, the most effective treatment was the Ficus carica L. leaf extract at 800 mg/kg, achieving 83.01% inhibition of gastric ulceration, compared with ranitidine, which achieved 73.58% inhibition. These results were obtained using the Marhuenda scale. It was determined that the ethanolic extract of Ficus carica L. leaves at a dose of 800 mg/kg presents antiulcer activity in rats.