Examinando por Autor "Alvarado Lopez, Lesly Lizeth"

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    Actividad sedante y ansiolítico del extracto etanólico de las hojas de Ruta chalepensis L. “ruda” en ratones
    (Universidad Privada Norbert Wiener, 2018-06-05) Alvarado Lopez, Lesly Lizeth; Castro Bolaños, Cinthia Melissa; Chávez Flores, Juana Elvira
    Ruta chalepensis L., "Ruda," is a plant widely distributed in the Mediterranean region and used in folk medicine as an antispasmodic, anthelmintic, antimicrobial, emmenagogue, and abortifacient. The plant species was collected in the Lima department, Lurín district, at 1224 m.a.s.l.. In this experimental study, the sedative and anxiolytic effect of the ethanolic extract from the leaves of Ruta chalepensis L., "Ruda," was confirmed in mice. A qualitative phytochemical profile was conducted. Subsequently, the study methods began: Sodium Pentobarbital-induced Sleep at different concentrations (100,250, and 500 mg/kg) and the Marble Burying Test at doses of 5,10, and 15 mg/kg. A total of 100 albino Balb/C53 strain mice of both sexes were used and distributed into five groups. It was confirmed that the most effective treatment in the Marble Burying Test was the ethanolic extract of Ruta chalepensis L., 'Ruda,' at 10 and 15 mg/kg, showing an effect superior to diazepam. Regarding the Sodium Pentobarbital-induced Sleep method, the comparison of the extracts versus diazepam indicates that the ethanolic extracts of Ruda at 250 and 500 mg/kg primarily have an effect similar to diazepam. Conclusion: The ethanolic extract from the leaves of Ruta chalepensis L., "Ruda," does possess sedative and anxiolytic activity.