Examinando por Autor "Arnao Rojas, Verónica"

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    Características de las reacciones adversas medicamentosas en pacientes con tratamiento antirretroviral de gran actividad en el programa del Centro Materno Infantil San José de Villa El Salvador, de 2006 a 2010
    (Universidad Privada Norbert Wiener, 2015) Arnao Rojas, Verónica; Ramírez Mendoza, Tania Alejandrina; Herencia Torres, Victor Reynaldo
    The present thesis, entitled Characteristics of Adverse Drug Reactions in Patients Under Highly Active Antiretroviral Therapy at the San José Maternal and Child Center Program in Villa El Salvador, 2006–2010, is an observational, descriptive, retrospective, and cross-sectional study. This thesis considered the antiretroviral drugs available at the Center for the Care and Treatment of Sexually Transmitted Infections and HIV/AIDS (CATITSS), including nucleoside reverse transcriptase inhibitors, non-nucleoside reverse transcriptase inhibitors, and protease inhibitors. A total of 420 clinical records of HIV-positive patients who were admitted to CATITSS at the San José Maternal and Child Center and met the inclusion criteria were reviewed. Among these, 268 patients presented one or more adverse reactions to antiretroviral drugs. The method used involved data collection from patient medical records; for each patient, a report form for suspected adverse reactions to antiretroviral drugs was completed. These reports were subsequently evaluated using the Peruvian pharmacovigilance algorithm. Regarding the results, the characteristics of adverse reactions to antiretroviral drugs by sex were 56.3% male and 43.7% female. By age group, 29.5% were 18–25 years, 36.6% were 26–32 years, 36.6% were 33–39 years, 7.1% were 47–53 years, and 7.8% were 54 years and older. By organs and systems affected, 44.78% involved the peripheral nervous system, 42.16% were related to metabolic and nutritional disorders, and 32.09% affected the skin. By type, the most frequent was type C at 89.93%, followed by type A at 61.19%. According to causality, 95.9% were classified as probable cases. Regarding severity, 52.10% were non-serious, 47.41% were serious, and only 0.49% were severe. According to the ATC classification of antiretrovirals, 97.28% of nucleoside reverse transcriptase inhibitors produced adverse drug reactions.