Examinando por Autor "Bonifacio Ccarhuaypiña, Lucero Lizeth"

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Acceso abierto
Evaluación de la toxicidad aguda del extracto etanólico de hojas de rumex cuneifolius campd. “romaza” en ratas Holtzman, Lima 2025
(Universidad Privada Norbert Wiener, 2026-01-07) Bonifacio Ccarhuaypiña, Lucero Lizeth; Retiz Sarmiento, Keila Sarith; Ñañez del Pino, Daniel
Rumex cuneifolius Campd., a perennial herbaceous species belonging to the Polygonaceae family, has long been known for its health benefits, but in large quantities, it can cause poisoning. Objective: To evaluate the acute toxicity of the ethanolic extract of Rumex cuneifolius Campd. leaves in Holtzman rats. Methodology: An experimental study was conducted, including a qualitative phytochemical analysis to determine the presence of primary and secondary metabolites. For the acute toxicity assessment, six rats were given a single oral dose of 300 mg/kg, adjusted to their weight. Another group of six rats received 2000 mg/kg, and four rats were given distilled water. After observing the experimental animals, they were euthanized to obtain biological samples, specifically liver and kidney tissue, for analysis. Results: The solubility of the extract was confirmed, and the presence of primary and secondary metabolites was observed. A notable increase in mean indirect and total bilirubin levels was observed in the hematological parameters. Furthermore, the histopathological study revealed congested portal tracts in the liver and glomeruli with damaged Bowman's capsules and vascular congestion in the kidneys. Finally, the Irvin test parameters showed significant acute toxicity at the extract dose. Conclusion: The extract was found to exhibit significant acute toxicity, with the highest toxicity observed at a dose of 2000 mg/kg.