Examinando por Autor "Cañari, Betsy"

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A systematic review of mental health in rural Andean populations in Latin America during the COVID-19 pandemic
(Frontiers Media SA, 2023-08-17) Moya-Salazar, Jeel; Jaime-Quispe, Alexis; Cañari, Betsy; Moya-Espinoza, Jeel G.; Contreras-Pulache, Hans
“Background: COVID-19 has been causing mental health problems around the world, with rural and indigenous peoples likely to be the most aected. This systematic review synthesizes and critically analyzes the existing literature on mental disorders in the rural Andean population in Latin America. Methods: A systematic review with narrative synthesis was carried out following the PRISMA guidelines. We searched nine databases (PubMed/MEDLINE, Scopus, EMBASE, ScienceDirect, Web of Science, Cochrane, Scielo, LILACS, and Latindex), five public prepublication servers (SocArXiv, medRxiv, bioRxiv, SportRXiv, and Preprints), ALICIA, and Google Scholar for articles that included the analysis of mental health problems using data collected from the rural Andean population in Latin America. These were eligible for inclusion. Articles that included NonLatin American populations (including European or African migrants) and studies conducted prior to the COVID-19 pandemic (since the declaration of national lockdown) were excluded. Results: A total of 23,761 articles were retrieved, 14 of which met the inclusion requirements. Most were cross-sectional (n = 12) and related to anxiety (n = 9), depression (n = 8), and stress (n = 5). The mental health analysis of 5,976 rural dwellers from four countries in Latin America also included gray literature studies (n = 7) that allowed the quantification of mental health problems in adults (n = 7) and adolescents/children (n = 4). Only one study was multinational, and the quality of publications varied. Despite the high frequency of anxiety, depression, and stress symptoms among rural Latin American populations during COVID-19, published research is very limited. This review found preliminary evidence that the frequency of anxiety (45%), depression (27.6%), and stress (33.1%) in the rural population was associated with pandemic restrictions across countries. Measures of other psychiatric problems, such as distress or suicidal ideation, cannot be estimated. Conclusion: Regional-wide studies investigating changes in the frequency of symptoms of mental health problems in the context of the COVID-19 pandemic are warranted to inform culturally adapted prevention strategies. This study is limited to a narrative synthesis and may be subject to publication bia“
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Alterations in the coagulation markers did not show differences with the severity of COVID-19 in Peruvian patients: A cross-sectional single-center study
(HEALTH SCIENCE REPORTS, 2023-03-15) Moya-Salazar, Jeel; Cóndor, Liliana Y.; Zuñiga, Nahomi; Jaime-Quispe, Alexis; Moya-Salazar, Jeel; Chicoma-Flores, Karina; Cañari, Betsy; Contreras-Pulache, Hans
Background and Aims:COVID‐19 is a pandemic disease that can lead to alteredlung function, systemic inflammatory events, and altered coagulation. During severestages of the disease, changes in coagulation homeostasis increase, leading tothrombosis, and increased risk of death. In this cross‐sectional study, we aimedto assess coagulation markers by COVID‐19 severity in Peruvian adults.Methods:During the second wave of infections, we included 186 adults diagnosedwith COVID‐19 (mean age 53.3 ± 16.3 years). Patients were divided into mild,moderate, and severe stages of COVID‐19, and coagulation markers includedprothrombin time (PT), activated partial prothrombin time (aPTT), fibrinogen,D‐dimer, and platelet count.Results:Of the total, 120 (64.5%) were males and 39 (21%) were in the intensivecare unit. We determine 104 (55.9%), 43 (24.7%), and 36 (19.4%) patients in mild,moderate, and severe stages of COVID‐19, respectively. In the severe stage ofCOVID‐19, patients had an average concentration of PT, aPTT, fibrinogen,D‐dimer,and platelets of 13.2 ± 0.9 s, 28.9 ± 4.3 s, 679.4 ± 185.1 mg/dL, 1.9 ± 3.1 μg/mL, and272.8 ± 88.9 cel/10 mm,3respectively. We found no differences in the concentra-tion of each marker according to severity (p< 0.05). Patients with severe COVID‐19had altered the aPTT, fibrinogen,D‐dimer, and PT in 31 (57.4%), 48 (88.9%), 37(68.5%), and 15 (27.8%) cases, respectively.Conclusions:Our results showed that although there is an alteration in coagulationmarkers, mainly fibrinogen andD‐fiber, there are no differences in concentrationaccording to the severity of COVID‐19
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Alterations in the coagulation markers did not showdifferences with the severity of COVID‐19 in Peruvianpatients: A cross‐sectional single‐center study
(John Wiley and Sons Inc, 2023-01-30) Moya‐Salaza, Jeel; Cóndor, Liliana Y.; Zuñiga, Nahomi; Jaime‐Quispe, Alexis; Cañari, Betsy; Contreras‐Pulache, Hans
Background and Aims:COVID‐19 is a pandemic disease that can lead to alteredlung function, systemic inflammatory events, and altered coagulation. During severestages of the disease, changes in coagulation homeostasis increase, leading tothrombosis, and increased risk of death. In this cross‐sectional study, we aimedto assess coagulation markers by COVID‐19 severity in Peruvian adults.Methods:During the second wave of infections, we included 186 adults diagnosedwith COVID‐19 (mean age 53.3 ± 16.3 years). Patients were divided into mild,moderate, and severe stages of COVID‐19, and coagulation markers includedprothrombin time (PT), activated partial prothrombin time (aPTT), fibrinogen,D‐dimer, and platelet count.Results:Of the total, 120 (64.5%) were males and 39 (21%) were in the intensivecare unit. We determine 104 (55.9%), 43 (24.7%), and 36 (19.4%) patients in mild,moderate, and severe stages of COVID‐19, respectively. In the severe stage ofCOVID‐19, patients had an average concentration of PT, aPTT, fibrinogen,D‐dimer,and platelets of 13.2 ± 0.9 s, 28.9 ± 4.3 s, 679.4 ± 185.1 mg/dL, 1.9 ± 3.1 μg/mL, and272.8 ± 88.9 cel/10 mm,3respectively. We found no differences in the concentra-tion of each marker according to severity (p< 0.05). Patients with severe COVID‐19had altered the aPTT, fibrinogen,D‐dimer, and PT in 31 (57.4%), 48 (88.9%), 37(68.5%), and 15 (27.8%) cases, respectively.Conclusions:Our results showed that although there is an alteration in coagulationmarkers, mainly fibrinogen andD‐fiber, there are no differences in concentrationaccording to the severity of COVID‐19.
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Can living with COVID-19 patients in a hospital increase anxiety levels? A survey-based single-center study in Peru
(Modestum LTD, 2022-02-25) Moya-Salazar, Jeel; Saciga-Saavedra, Walter; Cañari, Betsy; Chicoma-Flores, Karina; Contreras-Pulache, Hans
“Introduction: Anxiety can affect front-line healthcare workers (HCWs) during the COVID-19 pandemic mainly in settings with influencing factors. Living with COVID-19 patients in hospital settings could affect mental health during lockdown. The present study aimed to estimate the anxiety levels of HCWs of the care center for COVID-19 Villa Panamericana during the first outbreak of COVID-19 in Peru. Methods: This is a descriptive and correlational study. Ninety-six HCWs were enrolled in this study (mean age 30±5.6 years). The care center for COVID-19 Villa Panamericana houses COVID-19 patients and HCWs in the same environment. We used the 14-item Hamilton anxiety rating scale questionnaire. Professionals were interviewed directly at the VP-19 rest towers. SPSS V.23 were used to analyze the data. Results: Fifty-four (56.3%) were male and the most frequent age group was 26-35 years (81.3%). Thirty-nine (40.6%) were nurses, 28 (29.2%) were nursing technicians, 15 (15.6%) were physicians, and 14 (14.6%) were medical technologists. Of the total, 66 (68.8%) HCWs had a mild level of anxiety, while 6 (6.3%) had severe anxiety. Medical technologists and nursing technicians had the highest level of severe anxiety (14.3% and 7.1%), while nurses had the highest level of mild anxiety (76.9%). We report that 32 (33.3%) HCWs had COVID-19 while 93.7% had symptoms of anxiety [3(9.4%) mild to moderate, 21(65.6 %) moderate to severe, and 6(18.8%) severe]. We found a significant difference in anxiety levels between HCWs with and without COVID-19 (p=0.001). Conclusions: Levels of moderate and severe anxiety significantly increased in HCWs infected with COVID-19 during their coexistence with COVID-19 patients in the health center that houses both at the same time.“
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Changes in High-Density Lipoprotein (HDL), Low-Density Lipoprotein (LDL) and Cholesterol Concentration in Heavy Cannabis Users: A Single-Centre Study in Cusco, Peru
(MDPI, 2022-08-12) Cusihuaman, Sandro; Moya-Salazar, Jeel; Wong-Salgado, Pedro; Moya-Salazar, Marcia M.; Cañari, Betsy; Chicoma-Flores, Karina; Contreras-Pulache, Hans
“Background: The effect of cannabis on cholesterol and lipid balance has been reported for decades. However, there are conflicting reports on the reduction of low-density lipoprotein (LDL-C) and total cholesterol. The purpose of this study was to determine the immediate changes of Cannabis spp. consumption by pyrolytic route in heavy users. Methods: A cross-sectional study on 20 Peruvian heavy cannabis users (mean age: 31 ± 9.5 years). The inclusion criteria were males with an average weight of 50–70 kg, normal BMI, and having used cannabis, without association with other drugs, for at least one year with a high frequency per week (use: 4–7 days/week). High-density lipoprotein (HDL-C), LDL-C, and total cholesterol were evaluated 30 and 120 min after the administration of Cannabis spp. (~0.2 g by inhalation). Results: Of the total 12 (60%), 10 (50%), and 11 (55%) had desirable total cholesterol, fairly good HDL-C (40–60 mg/dL) and fairly good LDL-C (100–129 mg/dL) values, respectively. The mean basal concentration of total cholesterol, HDL-cholesterol, and LDL-cholesterol was 193.37 ± 20.18 mg/dL, 60.05 ± 6.36 mg/dL, and 129.65 ± 14.50 mg/dL, respectively. HDL-cholesterol showed progressive increases in participants with desirable HDL-C > 60 mg/dL at 30 min (10 vs. 14 participants, p < 0.001) and at 120 min (10 vs. 16 participants, p < 0.001), while LDL-C peaked in participants with concentrations <100 mg/dL at 30 min (desirable cholesterol: 0 vs. 2, p = 0.001). HDL-C concentration showed differences after cannabis consumption, showing increases at 30 (63.25 ± 7.68 mg/dL) and 120 min (69.15 ± 18.67 mg/dL) and total cholesterol concentration changed to 180.95 ± 19.3 mg/dL (95%CI 172.5 to 189.4) at 120 min (p = 0.007). Conclusions: HDL-C cholesterol increased 30 and 120 min after Cannabis spp. ingestion, while LDL-C and total cholesterol showed partial reductions in heavy-users from Cusco, Peru.“
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Changes in High-Density Lipoprotein (HDL), Low-Density Lipoprotein (LDL) and Cholesterol Concentration in Heavy Cannabis Users: A Single-Centre Study in Cusco, Peru
(MDPI, 2022-08-12) Cusihuaman , Sandro; Moya-Salazar, Jeel; Wong-Salgado, Pedro; Moya-Salazar, Marcia M.; Cañari, Betsy; Chicoma-Flores , Karina; Contreras-Pulache, Hans
“Background: The effect of cannabis on cholesterol and lipid balance has been reported for decades. However, there are conflicting reports on the reduction of low-density lipoprotein (LDL-C) and total cholesterol. The purpose of this study was to determine the immediate changes of Cannabis spp. consumption by pyrolytic route in heavy users. Methods: A cross-sectional study on 20 Peruvian heavy cannabis users (mean age: 31 ± 9.5 years). The inclusion criteria were males with an average weight of 50–70 kg, normal BMI, and having used cannabis, without association with other drugs, for at least one year with a high frequency per week (use: 4–7 days/week). High-density lipoprotein (HDL-C), LDL-C, and total cholesterol were evaluated 30 and 120 min after the administration of Cannabis spp. (~0.2 g by inhalation). Results: Of the total 12 (60%), 10 (50%), and 11 (55%) had desirable total cholesterol, fairly good HDL-C (40–60 mg/dL) and fairly good LDL-C (100–129 mg/dL) values, respectively. The mean basal concentration of total cholesterol, HDL-cholesterol, and LDL-cholesterol was 193.37 ± 20.18 mg/dL, 60.05 ± 6.36 mg/dL, and 129.65 ± 14.50 mg/dL, respectively. HDL-cholesterol showed progressive increases in participants with desirable HDL-C > 60 mg/dL at 30 min (10 vs. 14 participants, p < 0.001) and at 120 min (10 vs. 16 participants, p < 0.001), while LDL-C peaked in participants with concentrations <100 mg/dL at 30 min (desirable cholesterol: 0 vs. 2, p = 0.001). HDL-C concentration showed differences after cannabis consumption, showing increases at 30 (63.25 ± 7.68 mg/dL) and 120 min (69.15 ± 18.67 mg/dL) and total cholesterol concentration changed to 180.95 ± 19.3 mg/dL (95%CI 172.5 to 189.4) at 120 min (p = 0.007). Conclusions: HDL-C cholesterol increased 30 and 120 min after Cannabis spp. ingestion, while LDL-C and total cholesterol showed partial reductions in heavy-users from Cusco, Peru.“
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COVID-19 may lower quality of life when infections and deaths increase: A longitudinal study in the Peruvian jungle
(Frontiers Media S.A., 2023-03-28) Moya-Salazar, Jeel; Villareal, Chris A.; Cañari, Betsy; Moya-Salazar, Belén; Chicoma-Flores, Karina; Contreras-Pulache, Hans
“Background: Quality of life (QoL) is a multifactorial concept on the perception of the individual’s wellbeing underpinned by environmental, psychological, and physical factors. Several studies have shown changes in QoL in the COVID-19 pandemic and may be due to increases in mortality rates, however, no study has investigated this among Peruvian jungle dwellers. Here, we have sought to estimate the QoL of individuals before and after the increase in cases and deaths from COVID-19. Methods: A questionnaire-based longitudinal study was conducted in 102 inhabitants (mean 40.75 ± 7.49 years). The Spanish version of the WHOQOL-BREF was used in two stages: April and June. The first stage was accomplished before the first confirmed case of COVID-19, and the second stage was when the daily mortality rate was 3.5% with an incidence of 87%. Results: Sixty (54.8%) participants were women, 67 (61.9%) were >31 years, and 38 (34.5%) and 32 (29.1%) participants had primary and secondary education, respectively. In the first and second stage we obtained an overall mean QoL of 46.65 ± 23.2 and 35 ± 27.7 points, respectively. Individuals had significantly lower QoL in the face of increased deaths in physical (p = 0.001), mental (p = 0.028) and environmental (p = 0.001) health domains, with the latter having the greatest impact (51.84 ± 5.81 vs. 16.66 ± 5.55 points). Conclusion: Quality of life of Peruvian jungle dwellers is reduced during periods of increased mortality and incidence by COVID-19. Preventive strategies aimed at reducing the impact of COVID-19 on the mental health and global wellbeing of individuals living in the Amazon are recommended to Peruvian authorities.“
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COVID-19 may lower quality of life when infections and deaths increase: A longitudinal study in the Peruvian jungle
(Frontiers Media S.A., 2023-03-28) Moya-Salazar, Jeel; Villareal, Chris A.; Cañari, Betsy; Moya-Salazar, Belén; Chicoma-Flores, Karina; Contreras-Pulache, Hans
“Background: Quality of life (QoL) is a multifactorial concept on the perception of the individual’s wellbeing underpinned by environmental, psychological, and physical factors. Several studies have shown changes in QoL in the COVID-19 pandemic and may be due to increases in mortality rates, however, no study has investigated this among Peruvian jungle dwellers. Here, we have sought to estimate the QoL of individuals before and after the increase in cases and deaths from COVID-19. Methods: A questionnaire-based longitudinal study was conducted in 102 inhabitants (mean 40.75 ± 7.49 years). The Spanish version of the WHOQOL-BREF was used in two stages: April and June. The first stage was accomplished before the first confirmed case of COVID-19, and the second stage was when the daily mortality rate was 3.5% with an incidence of 87%. Results: Sixty (54.8%) participants were women, 67 (61.9%) were >31 years, and 38 (34.5%) and 32 (29.1%) participants had primary and secondary education, respectively. In the first and second stage we obtained an overall mean QoL of 46.65 ± 23.2 and 35 ± 27.7 points, respectively. Individuals had significantly lower QoL in the face of increased deaths in physical (p = 0.001), mental (p = 0.028) and environmental (p = 0.001) health domains, with the latter having the greatest impact (51.84 ± 5.81 vs. 16.66 ± 5.55 points). Conclusion: Quality of life of Peruvian jungle dwellers is reduced during periods of increased mortality and incidence by COVID-19. Preventive strategies aimed at reducing the impact of COVID-19 on the mental health and global wellbeing of individuals living in the Amazon are recommended to Peruvian authorities.“
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Depression in healthcare workers from the COVID-19 Care and Isolation Center - Villa Panamericana: a single-center prospective study in Peru
(NLM (Medline), 2022-04-13) Moya-Salazar, Jeel; Saciga-Saavedra, Walter; Cañari, Betsy; Contreras-Pulache, Hans
Objective: Depression is a mental problem that affects the well-being of healthcare workers, impacting the quality of care and even leading to commit suicide. We aim to the levels of depression in frontline healthcare workers during the first severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak in Peru. Methods: A prospective cohort study was designed in the coronavirus disease 2019 (COVID-19) Care and Isolation Center – Villa Panamericana in eastern Lima. Care and Isolation Center-Villa Panamericana houses about 150 healthcare workers and COVID-19 patients. The Montgomery-Asberg Depression Rating scale was used for depression assessment. Results: A total of 96 participants (30±5.6 years) were analyzed: 15 (15.6%) physicians, 39 (40.6%) nurses, 14 (14.6%) medical technologists, and 28 (29.2%) nurse technicians. Mild, moderate, and severe depression were present in 35 (36.5%), 44 (45.8%), and 9 (9.4%) of the cases, respectively. The physicians and nurses reported more severe levels of depression: 8 (53.3%) physicians and 18 (46.2%) nurses presented moderate depression; and 2 (13.3%) physicians and 3 (7.7%) nurses presented severe depression (p=0.005). This study determined greater symptoms of depression according to years of work (p=0.001). Thirty-two healthcare workers had COVID-19, 4 (12.5%) physicians, 9 (28.1%) nurses, 7 (21.9%) medical technologists, and 12 (37.5%) nurse technicians. Twenty-four (75%) participants showed symptoms of COVID-19 and developed moderate (12 [37.5%]) and severe (3 [9.4%]) symptoms of depression (p=0.041). Conclusion: This study clearly demonstrated a high prevalence of depression in the Care and Isolation Center-Villa Panamericana frontline healthcare workers during the COVID-19 pandemic in Peru.
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Depression in healthcare workers from the COVID-19 Care and Isolation Center - Villa Panamericana: a single-center prospective study in Peru
(INST ISRAELITA ENSINO & PESQUISA ALBERT EINSTEIN, 2022-04-13) Moya-Salazar, Jeel; Saciga-Saavedra, Walter; Cañari, Betsy; Contreras-Pulache, Hans
“Objective Depression is a mental problem that affects the well-being of healthcare workers, impacting the quality of care and even leading to commit suicide. We aim to the levels of depression in frontline healthcare workers during the first severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak in Peru. Methods A prospective cohort study was designed in the coronavirus disease 2019 (COVID-19) Care and Isolation Center – Villa Panamericana in eastern Lima. Care and Isolation Center-Villa Panamericana houses about 150 healthcare workers and COVID-19 patients. The Montgomery-Asberg Depression Rating scale was used for depression assessment. Results A total of 96 participants (30±5.6 years) were analyzed: 15 (15.6%) physicians, 39 (40.6%) nurses, 14 (14.6%) medical technologists, and 28 (29.2%) nurse technicians. Mild, moderate, and severe depression were present in 35 (36.5%), 44 (45.8%), and 9 (9.4%) of the cases, respectively. The physicians and nurses reported more severe levels of depression: 8 (53.3%) physicians and 18 (46.2%) nurses presented moderate depression; and 2 (13.3%) physicians and 3 (7.7%) nurses presented severe depression (p=0.005). This study determined greater symptoms of depression according to years of work (p=0.001). Thirty-two healthcare workers had COVID-19, 4 (12.5%) physicians, 9 (28.1%) nurses, 7 (21.9%) medical technologists, and 12 (37.5%) nurse technicians. Twenty-four (75%) participants showed symptoms of COVID-19 and developed moderate (12 [37.5%]) and severe (3 [9.4%]) symptoms of depression (p=0.041). Conclusion This study clearly demonstrated a high prevalence of depression in the Care and Isolation Center-Villa Panamericana frontline healthcare workers during the COVID-19 pandemic in Peru.“
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“Detection of pathogenic Aeromonas hydrophila from two rainbow trout (Oncorhynchus mykiss) farms in Peru“
(Society of Veterinary Medicine of the State of Rio de Janeiro, 2022-11-09) Moya-Salazar, Jeel; Díaz, Carmen Rosa; Cañari, Betsy; Badillo, Renato Xavier; Verano-Zelada, Mario; Chicoma-Flores, Karina; Contreras-Pulache, Hans
“Fish farms are one of the principal food industries located in peri-urban and rural communities that use available resources to ensure the quality of their products. However, trout can suffer from bacterial infections affecting the sector and being a key component of human health risk. We aimed to identify and characterize Enterobacteriaceae in 46 trout (Oncorhynchus mykiss) in two fish farms in Lima, Peru. Adult trouts older than seven weeks (> 200 grams weight) were included. Cultures were performed in duplicate (n=192 trials) with swabs from the squamous surface and visceral cavity. The isolates were identified with the Vitek® 2 Compact system, and the minimum inhibitory concentrations (MIC) were interpreted with the CLSI VET 03-A guide. At El Molino and El Angelito fish farms, 66 (68.8%) and 57 (59.4%) isolates were obtained. The most frequently isolated species were Escherichia coli (56.8%), Proteus sp. (4.2%) and Klebsiella pneumoniae (2.6%). E. coli was present in all sampling areas, and Aeromonas hydrophila was only present in one open viscera sample at El Angelito fish farm. A. hydrophila showed antibiotic resistance to Ampicillin/Sulbactam (≥32 MIC), Oxytetracycline (>8 MIC), Imipenem (8 MIC), Levofloxacin (>8 MIC), and Ceftazidime (≥64 MIC). Our results suggest the presence of multi-resistant A. hydrophila in O. mykiss. Further studies are needed to understand the developmental context of A. hydrophila, which is crucial to the food industry, aquaculture and public health.“
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How much Fear of COVID-19 is There in Latin America? A Prospective Exploratory Study in Six Countries
(Modestum LTD, 2021-12-02) Moya-Salazar, Jeel; Cañari, Betsy; Contreras-Pulache, Hans
“Introduction: During the unprecedented lockdown, COVID-19 is causing people to suffer from mental disorders in response to strict containment measures. Latin America is the third most severely affected continent, and restrictive measures can have many negative effects on mental health (such as anxiety, depression, and stress) that may arise with fear. We aimed to measure the spread of fear of COVID-19 in the Latin American population. Materials and Methods: We conducted a prospective study in 535 participants of six countries of Latin America (Argentina, Bolivia, Colombia, Guatemala, Mexico, and Peru), and a country of Europe (Spain) as a control, during 2020. We used the Fear of COVID-19 Scale. Results: The mean age was 31.2±13.2 years (70.8% under 30 years) and the majority were women (57.9%) and 76.6% had a technical, university, or postgraduate studies. Seven percent of participants had high rates of fear of COVID-19, these high estimates of fear were observed in Argentines (14.3%, score range: 28-31%), of Peruvians (10.2%, score range: 27-35%), and Mexicans (5.7%, score range: 27-29%). Both Peru (p=0.003) and Mexico (p=0.0001) showed significant differences from the control country. We showed low levels of fear in 57.1%, 45.5%, 42.9%, and 41.2% of Argentines, Colombians, Bolivians, and Peruvians, respectively. No differences in low levels of fear we found among age groups (p> 0.05), however, we find differences between genders (p=0.001). Conclusions: These results suggested low levels of fear in six Latin American countries, highlighting the need to contextualize fear behavior as a key element in people’s psychological well-being and mental health during the COVID-19 pandemic.“
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How much Fear of COVID-19 is There in Latin America? A Prospective Exploratory Study in Six Countries
(Modestum LTD, 2021-12-02) Moya-Salazar, Jeel; Cañari, Betsy; Contreras-Pulache, Hans
Introduction: During the unprecedented lockdown, COVID-19 is causing people to suffer from mental disorders in response to strict containment measures. Latin America is the third most severely affected continent, and restrictive measures can have many negative effects on mental health (such as anxiety, depression, and stress) that may arise with fear. We aimed to measure the spread of fear of COVID-19 in the Latin American population. Materials and Methods: We conducted a prospective study in 535 participants of six countries of Latin America (Argentina, Bolivia, Colombia, Guatemala, Mexico, and Peru), and a country of Europe (Spain) as a control, during 2020. We used the Fear of COVID-19 Scale. Results: The mean age was 31.2±13.2 years (70.8% under 30 years) and the majority were women (57.9%) and 76.6% had a technical, university, or postgraduate studies. Seven percent of participants had high rates of fear of COVID-19, these high estimates of fear were observed in Argentines (14.3%, score range: 28-31%), of Peruvians (10.2%, score range: 27-35%), and Mexicans (5.7%, score range: 27-29%). Both Peru (p=0.003) and Mexico (p=0.0001) showed significant differences from the control country. We showed low levels of fear in 57.1%, 45.5%, 42.9%, and 41.2% of Argentines, Colombians, Bolivians, and Peruvians, respectively. No differences in low levelsof fear we found among age groups (p> 0.05), however, we find differences between genders (p=0.001). Conclusions: These results suggested low levels of fear in six Latin American countries, highlighting the need to contextualize fear behavior as a key element in people’s psychological well-being and mental health during the COVID-19 pandemic.
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Reference intervals of the sex hormonal profile in healthy women: A retrospective single-center study in Peru
(Elsevier Ltd, 2022-09-01) Moya-Salazar, Jeel; Cerda, Sandra P.; Cañari, Betsy; Moya-Salazar, Marcia M.; Contreras-Pulache, Hans
The female hormonal profile is of utmost importance for the assessment of the endocrinological functional status and the diagnosis of diseases. The analysis must delimit their normality intervals based on the manufacturer's cut-off points. Due to not all intervals can be evaluated before use, it is imperative to verify the reference intervals to achieve uniformity in the interpretation of results in the female population. We determine the reference intervals of five female sex hormones [Follicle Stimulating hormone (FSH), Estradiol, Luteinizing Hormone (LH), Prolactin, and progesterone] using electrochemiluminescence in the Cobas e411 (Roche). We included female patients >18 years old, between the 3rd and 15th day of the menstrual cycle (follicular phase) and had no previous medical history or recent medication. For reference intervals analysis, we followed the recommendations of the CLSI C28-A3 guideline. The average concentration for FSH, progesterone, LH, prolactin and estradiol were 11.48 ± 21.10 mIU/ml, 8.19 ± 11.90 ng/ml, 10.98 ± 11.55 ng/ml, 25.05 ± 32.74 ng/mL, and 147.08 ± 473.8 pmol/mL, respectively. Eighty per cent of parameters showed a satisfactory transfer for the manufacturer's reference intervals, except for estradiol, which had 85.5% of transferred values. Our results suggest that 4/5 sex hormones were found within the manufacturer's reference intervals and can be quantified in Peruvian women, ensuring the quality of their results. However, it is necessary to determine the estradiol with other reagents and assays since we show errors in the transfer of intervals.
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Reference intervals of the sex hormonal profile in healthy women: A retrospective single-center study in Peru
(Elsevier Ltd, 2022-09-01) Moya-Salazar, Jeel; Cerda, Sandra P.; Cañari, Betsy; Moya-Salazar, Marcia M.; Contreras-Pulache, Hans
The female hormonal profile is of utmost importance for the assessment of the endocrinological functional status and the diagnosis of diseases. The analysis must delimit their normality intervals based on the manufacturer's cut-off points. Due to not all intervals can be evaluated before use, it is imperative to verify the reference intervals to achieve uniformity in the interpretation of results in the female population. We determine the reference intervals of five female sex hormones [Follicle Stimulating hormone (FSH), Estradiol, Luteinizing Hormone (LH), Prolactin, and progesterone] using electrochemiluminescence in the Cobas e411 (Roche). We included female patients >18 years old, between the 3rd and 15th day of the menstrual cycle (follicular phase) and had no previous medical history or recent medication. For reference intervals analysis, we followed the recommendations of the CLSI C28-A3 guideline. The average concentration for FSH, progesterone, LH, prolactin and estradiol were 11.48 ± 21.10 mIU/ml, 8.19 ± 11.90 ng/ml, 10.98 ± 11.55 ng/ml, 25.05 ± 32.74 ng/mL, and 147.08 ± 473.8 pmol/mL, respectively. Eighty per cent of parameters showed a satisfactory transfer for the manufacturer's reference intervals, except for estradiol, which had 85.5% of transferred values. Our results suggest that 4/5 sex hormones were found within the manufacturer's reference intervals and can be quantified in Peruvian women, ensuring the quality of their results. However, it is necessary to determine the estradiol with other reagents and assays since we show errors in the transfer of intervals.
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Substance Use in Healthcare Professionals During the COVID-19 Pandemic in Latin America: A Systematic Review and a Call for Reports
(SAGE Publications Ltd, 2022-03-29) Moya-Salazar, Jeel; Nuñez, Elizabeth; Jaime-Quispe, Alexis; Zuñiga, Nahomi; Loaiza-Barboza, Isabel L; Balabarca, Edison A; Chicoma-Flores, Karina; Cañari, Betsy; Contreras-Pulache, Hans
BACkgROUnD: The COVID-19 pandemic has generated a remarkable change in the behaviour of Healthcare workers (HCWs) around the world. However, there is a lack of evidence on substance use among HCWs in Latin America. Therefore, this study aimed to determine the current frequency of substance use among Latin American among HCWs.MeTHODS: We searched 8 databases (PubMed, Scopus, ScientDirect, Web of Science, Cochrane, Scielo, LILACS and Latindex), 4 public prepublication servers (SocArXiv, medRxiv, bioRxiv and Preprints) and Google scholar from 1/9/2019 to 11/1/2021. We determined the fre-quency of each study based on original studies, scientific letters, and clinical trials in English, Spanish and Portuguese.ReSULT S: A total of 17 175 study articles were identified from electronic databases and preprints, and 2 cross-sectional studies conducted in 2020 were included in the qualitative analysis. Both studies included HCWs but did not perform a differential analysis. The first was devel-oped by the Pan-American Health Organization and included interviewees from 35 countries, while the second was conducted with 1145 Brazilian participants. Both studies showed increases in substance use during the pandemic, with alcohol being the most commonly used substance (30%), but PAHO’s study reported a 13.8% increase in self-reported heavy-episodic drinking, with differences among genders (males, 15.4%), age groups (highest increase in the 40-49 age group, 16.5%) and area of residence (urban with 14%). The second study showed that 21 32% of participants reported initiating psychoactive substance use, 29.3% added some substance to their initial use and 4% of them had to replace the substance, mainly due to difficulty of access. Other substances of abuse that showed significant increases were tobacco (0.5%) and marijuana (0.3%).COnCLUSIOn: Overall, despite the analysis of the 2 studies, the results provided are not a conclusive description of the frequency of sub-stance use by HCWs in Latin America during the COVID-19 pandemic. Further research is required to understand the impact of the pan-demic on drug abuse in the region.PROTOCOL RegISTRATIOn: The protocol has been registered on 30 November 2021 on the International Prospective Register of System-atic Reviews (PROSPERO) with ID: CRD420212919700
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Substance Use in Healthcare Professionals During the COVID-19 Pandemic in Latin America: A Systematic Review and a Call for Reports
(SAGE Publications Ltd, 2022-03-29) Moya-Salazar, Jeel; Nuñez, Elizabeth; Jaime-Quispe, Alexis; Zuñiga, Nahomi; Loaiza-Barboza, Isabel L; Balabarca, Edison A; Chicoma-Flores, Karina; Cañari, Betsy; Contreras-Pulache, Hans
BACkgROUnD: The COVID-19 pandemic has generated a remarkable change in the behaviour of Healthcare workers (HCWs) around the world. However, there is a lack of evidence on substance use among HCWs in Latin America. Therefore, this study aimed to determine the current frequency of substance use among Latin American among HCWs.MeTHODS: We searched 8 databases (PubMed, Scopus, ScientDirect, Web of Science, Cochrane, Scielo, LILACS and Latindex), 4 public prepublication servers (SocArXiv, medRxiv, bioRxiv and Preprints) and Google scholar from 1/9/2019 to 11/1/2021. We determined the fre-quency of each study based on original studies, scientific letters, and clinical trials in English, Spanish and Portuguese.ReSULT S: A total of 17 175 study articles were identified from electronic databases and preprints, and 2 cross-sectional studies conducted in 2020 were included in the qualitative analysis. Both studies included HCWs but did not perform a differential analysis. The first was devel-oped by the Pan-American Health Organization and included interviewees from 35 countries, while the second was conducted with 1145 Brazilian participants. Both studies showed increases in substance use during the pandemic, with alcohol being the most commonly used substance (30%), but PAHO’s study reported a 13.8% increase in self-reported heavy-episodic drinking, with differences among genders (males, 15.4%), age groups (highest increase in the 40-49 age group, 16.5%) and area of residence (urban with 14%). The second study showed that 21 32% of participants reported initiating psychoactive substance use, 29.3% added some substance to their initial use and 4% of them had to replace the substance, mainly due to difficulty of access. Other substances of abuse that showed significant increases were tobacco (0.5%) and marijuana (0.3%).COnCLUSIOn: Overall, despite the analysis of the 2 studies, the results provided are not a conclusive description of the frequency of sub-stance use by HCWs in Latin America during the COVID-19 pandemic. Further research is required to understand the impact of the pan-demic on drug abuse in the region.PROTOCOL RegISTRATIOn: The protocol has been registered on 30 November 2021 on the International Prospective Register of System-atic Reviews (PROSPERO) with ID: CRD420212919700
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“What is the perception of medical students about eLearning during the COVID-19 pandemic? A multicenter study in Peru“
(Modestum LTD, 2022-07-13) Moya-Salazar, Jeel; Jaime-Quispe, Alexis; Milachay, Yeferson S.; Cañari, Betsy; Lozano-Zanely, Glenn; Chicoma-Flores, Karina; Moya-Salazar, Marcia M.; Contreras-Pulache, Hans
“Introduction: As face-to-face medical education was restricted during the pandemic; digital tools have been deployed to continue education showing a good educational impact in most countries. However, the perception of medical students in Peru on eLearning has not yet been investigated. This study assessed the perception of 440 medical students from two national universities in Peru on the characteristics and limitations of eLearning during 2021. Materials and methods: We conducted a cross-sectional study using the self-administered survey Encuesta Virtual en Tiempos de COVID-19 (EVI-CV19) on students between the second and sixth medical year of the Universidad Nacional Mayor de San Marcos (UNMSM) and the Universidad Nacional San Luis Gonzaga (UNSLG, n=325). Results: The majority of students were under 30 years of age (93.9% vs. 97.2%, p=0.084), and female (67% vs. 64%, p=0.107). Of the total, 63.9% and 81.5% UNMSM and UNSLG students considered the virtual platform effective in favouring feedback with recorded lectures (85.2% vs. 85.5%) and the organization of documents (61.7% vs. 80.9%), respectively (p>0.05). Seventy per cent and 46.8% of UNMSM and UNSLG students perceived that teachers were nottrained (p=0.063), and 26.1% and17.2% of students perceived thatthe virtual modality affected their academic performance a lot, respectively (p=0.003). About 38% of students from both universities perceived the virtual platforms as very secure. We found differences between UNMSM and UNSLG students on whether the virtual exams were fair (28.7% vs. 52.3%, p<0.001). Conclusions: This study reported a favorable perception of medical eLearning with clear differences in the limitations of the virtual environment.“
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Where Do Medical Students Look for Information? A Study on Scientific Consultation Sources in Peru
(Modestum LTD, 2022-02-02) Moya-Salazar, Jeel; Cañari, Betsy; Jaime-Quispe, Alexis; Chicoma-Flores, Karina; Contreras-Pulache, Hans
“Introduction: Scientific consultation sources is essential in the quality of information during medical training worldwide. The sources of consultation should provide quality information to students who begin with clinical courses; however, it is unknown how and where students seek data in all medical schools in Peru. In this study, we determine the most frequent sources of scientific consultation of medical students at Norbert Wiener University. Materials and methods: We conducted a survey-based observational study in 148 volunteers (mean age 22.1±5.4 years) during 2019. A 21-items questionnaire was divided into three components: demographic data (10 questions), scientific consultation sources (7 questions), and Information search engines (4 questions). Results: Eighty (54.1%) students were between 20-30 years, and 26.8% worked < 20 hours per week. The scientific search sources considered very usefully were scientific articles (75.4%) and specialized books (49.3%), while 33% did not know Medscape. Regarding audiovisual sources, documentaries on the history of medicine and YouTube were considered useful in 41% and 48%, respectively. We found differences in the use of consultation sources (p =0.031), Medscape (p =0.001), documentaries (p=0.009), and YouTube (p=0.022) among medical years. Sixty-three percent considered Wikipedia useful, and 19.3% used PubMed, while Google was the most frequent information search engine, followed of Scielo and Google scholar. We found a correlation between year of students and SciELO (p=0.024) and Google (p=0.024) engine use. Conclusions: Our results suggest that scientific articles, specialized books and audiovisual sources (documentaries and YouTube) were convenient for medical students. In addition, we have found that as students’ progress through the years in medical school, they make less use of rigorous scientific reference sources.“
Acceso abierto
Where Do Medical Students Look for Information? A Study on Scientific Consultation Sources in Peru
(Modestum LTD, 2022-02-02) Moya-Salazar, Jeel; Cañari, Betsy; Jaime-Quispe, Alexis; Chicoma-Flores, Karina; Contreras-Pulache, Hans
“Introduction: Scientific consultation sources is essential in the quality of information during medical training worldwide. The sources of consultation should provide quality information to students who begin with clinical courses; however, it is unknown how and where students seek data in all medical schools in Peru. In this study, we determine the most frequent sources of scientific consultation of medical students at Norbert Wiener University. Materials and methods: We conducted a survey-based observational study in 148 volunteers (mean age 22.1±5.4 years) during 2019. A 21-items questionnaire was divided into three components: demographic data (10 questions), scientific consultation sources (7 questions), and Information search engines (4 questions). Results: Eighty (54.1%) students were between 20-30 years, and 26.8% worked < 20 hours per week. The scientific search sources considered very usefully were scientific articles (75.4%) and specialized books (49.3%), while 33% did not know Medscape. Regarding audiovisual sources, documentaries on the history of medicine and YouTube were considered useful in 41% and 48%, respectively. We found differences in the use of consultation sources (p =0.031), Medscape (p =0.001), documentaries (p=0.009), and YouTube (p=0.022) among medical years. Sixty-three percent considered Wikipedia useful, and 19.3% used PubMed, while Google was the most frequent information search engine, followed of Scielo and Google scholar. We found a correlation between year of students and SciELO (p=0.024) and Google (p=0.024) engine use. Conclusions: Our results suggest that scientific articles, specialized books and audiovisual sources (documentaries and YouTube) were convenient for medical students. In addition, we have found that as students’ progress through the years in medical school, they make less use of rigorous scientific reference sources.“