Examinando por Autor "Castañeda Campos, Elsa Rosario"

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    Efecto sedante y ansiolítico del extracto hidroalcohólico de las hojas de Solanum corneliomulleri J.F. Macbr. “Sandillón” en ratones
    (Universidad Privada Norbert Wiener, 2022-07-09) Castañeda Campos, Elsa Rosario; Castañeda Campos, Willy German; Ramos Jaco, Antonio Guillermo
    The sedative and anxiolytic effects of medicinal plants constitute a safe alternative for the treatment of diseases associated with depression. Objective: To demonstrate the sedative and anxiolytic effects of the hydroalcoholic extract of the leaves of Solanum corneliomulleri J.F. Macbr. (“sandillón”) in mice. Methods: This was an experimental, prospective study. Secondary metabolites in the leaves were determined qualitatively. To demonstrate the sedative effect, the pentobarbital sodium-induced sleep method was employed, comparing extract doses of 100, 250, and 500 mg/kg. To demonstrate the anxiolytic effect, the hole-board method was used, comparing extract doses of 5, 10, and 15 mg/kg. Two groups of 40 male albino mice of the Balb/C53/CNPB strain were used: a negative control group receiving distilled water and a positive control group receiving diazepam at 10 mg/kg. Results: The 250 mg/kg extract dose produced the longest average sleep duration (2.8 hours), showing the greatest sedative effect. The 15 mg/kg dose produced the highest anxiolytic effect. Both effects were statistically significant, although slightly lower compared to the diazepam 10 mg/kg control group. The sedative effect of the hydroalcoholic extract at doses of 100, 250, and 500 mg/kg was 70.3%, 82.4%, and 81.6%, respectively, compared with diazepam 10 mg/kg. The anxiolytic effect at 10 mg/kg extract dose exceeded diazepam, showing an anxiety inhibition of 59.7%. The presence of alkaloids and other secondary metabolites was identified, which may be associated with the sedative and hypnotic effect. Conclusion: The hydroalcoholic extract of Solanum corneliomulleri leaves exhibits sedative and anxiolytic effects at doses of 100, 250, and 500 mg/kg, showing significant pharmacological activity, though slightly lower than diazepam. The presence of alkaloids and other metabolites suggests a possible mechanism for the observed effects.