Examinando por Autor "Celis Perez, Rosario Del Pilar"

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    Efficacy of acetaminophen in promoting closure of patent ductus arteriosus in premature newborns
    (Universidad Privada Norbert Wiener, 2017-11-12) Celis Perez, Rosario Del Pilar; Espil Sanchez, Sarita Milena; Bonilla Asalde, César Antonio
    Materials and methods: Observational and retrospective systematic review. The search was restricted to full-text articles, and the selected articles were subjected to a critical reading using the GRADE system to assign the strength of recommendation. A total of 10 articles were selected, with 30% (3) from Turkey, 20% (2) from Italy, and 10% (1) each from Ecuador, Mexico, India, Ireland, and China, respectively. The majority of the studies reviewed were randomized controlled trials, accounting for 80%, primarily from Turkey, India, Ireland, China, Italy, Mexico, and Ecuador. Systematic reviews and meta-analyses were found from Italy, Turkey, and China, accounting for 20%. Results: 30% (3) of the articles showed that the safety profiles of paracetamol and ibuprofen are similar, 20% (2) of the articles demonstrated that paracetamol can be a medical alternative in the treatment of ductus closure. 80% (8) of the articles showed that intravenous paracetamol, compared to intravenous indomethacin, is more effective in promoting closure of the patent ductus arteriosus in premature newborns. Conclusions: The reviewed studies showed that the use of acetaminophen is a promising and safe alternative for the treatment of patent ductus arteriosus in premature newborns.