Examinando por Autor "Chihua Enciso, Deysi Magdalena"

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Acceso abierto
In vitro effect of generic paracetamol and ibuprofen in syrups marketed in Peru, on salival ph. Lima 2023
(Universidad Privada Norbert Wiener, 2023-12-06) Chihua Enciso, Deysi Magdalena; Salcedo Rioja, Mercedes Rita
The objective of this study was to compare the in vitro effect of generic paracetamol and ibuprofen on salivary pH. The research used a hypothetical deductive method with a quantitative approach, applied type, and a completely randomized experimental design with one factor (type of solution). The number of replicates for each solution was determined with a 95% confidence level and 90% power. Thirty saliva samples were collected for each solution, with samples randomly assigned to each solution. Each sample contained 1.1 ml of saliva, with 30 samples assigned randomly to a 120mg/5ml paracetamol solution and 30 to a 100mg/5ml ibuprofen solution. 1.1 ml of each solution was added to each sample, and pH was recorded at 0, 15, and 30 minutes. Statistical analysis was performed using summary indicators of position and dispersion, and after applying normality tests to the variables, inferences were made using Student’s t-tests for comparing the means of two independent samples. The average salivary pH was 7.58, the paracetamol solution had a pH of 4.97, and ibuprofen had a pH of 4.05. The average pH recorded at time zero, when each solution was added to the samples, was 5.76 for paracetamol and 4.39 for ibuprofen. After 15 minutes, the average pH for paracetamol was 5.91 and for ibuprofen, it was 4.45. After 30 minutes, the average pH of the samples containing paracetamol was 5.93, and for those containing ibuprofen, it was 4.50. Conclusions: A critical pH level was achieved at all three time points with ibuprofen, affecting the saliva's ability to neutralize acids