Examinando por Autor "Contreras Agustin, Kely Luz"

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Interacciones medicamentosas potenciales en las prescripciones médicas de la unidad de cuidados intensivos de la Clínica Internacional sede Lima de enero a marzo de 2018
(Universidad Privada Norbert Wiener, 2018-12-07) Contreras Agustin, Kely Luz; Torres Veliz, Ernesto Raúl
The objective of the present study was to identify the potential drug interactions in medical prescriptions of the Intensive Care Unit of the Clínica Internacional. The study was retrospective, descriptive, and cross-sectional, conducted between January and March 2018, considering the selection criteria. Uptodate®-Lexicomp® and Pearson’s correlation test were used. A total of 444 medical prescriptions were analyzed, of which 355 presented at least one interaction, yielding 1646 interactions. The most frequent were fentanyl + midazolam with 59 (3.6%). The most frequent pharmacological group was opioid analgesics with 371 (11.3%). The most frequent medications were fentanyl 236 (7.2%), phenytoin 208 (6.4%), risperidone 169 (5.2%), furosemide 162 (5%), and metoclopramide 155 (4.7%). According to the type of interaction, pharmacodynamic were 1135 (69%), pharmacokinetic 462 (28%), and of unknown origin 49 (3%). According to their risk rating category, 179 (11%), 1042 (63%), 296 (18%), and 129 (8%) corresponded to categories B, C, D, and X, respectively. According to the degree of severity, 436 (26.5%) were major, 1068 (64.9%) moderate, and 142 (8.6%) minor. The relationship between the number of prescribed medications and the number of potential drug interactions was evaluated, determining a significant high positive correlation coefficient.