Examinando por Autor "Contreras Bustos, Mirtha"

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    Effectiveness of tranexamic acid use in cardiac surgery with extracorporeal circulation to reduce blood transfusion needs
    (Universidad Privada Norbert Wiener, 2018-11-24) Vidal Alvarez, Sonia; Contreras Bustos, Mirtha; Glenni Garay, Zarely Zabeli
    Objective: Systematize the evidence on the effectiveness of the use of tranexamic acid in cardiac surgery with extracorporeal circulation to reduce the need for blood transfusions. Materials and methods: systematic review that synthesizes the results of multiple investigations, identifying the most relevant. The PICO method was used to structure the research question, the CASPE templates were applied to the articles for validation and relevance, and a summary table of quality of evidence and strength of recommendation was prepared by applying the GRADE templates. Results: in the final selection, 10 articles were chosen, finding that 60% correspond to Europe (Spain, Belgium, France and Germany), 20% America (Canada and Cuba), 10% Asia (India) and 10% Africa ( Ethiopia). Most of them are experimental studies (60%), systematic reviews (20%) and cohorts (20%). 80% of reviews had high and 20% moderate quality of evidence, 100% had strong recommendation strength. 80% were performed on adult patients and 20% on pediatric patients. 100% concluded that the use of tranexamic acid reduces blood loss. Conclusion: From the reviewed articles it is evident that the use of tranexamic acid is effective in reducing blood loss, which contributes to the reduction of blood transfusions.