Examinando por Autor "Donayre Navarro, María Aurora del Rosario"

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    Effectiveness of the accelerated scheme against hepatitis B compared to the standardized scheme for seroconversion in at-risk population.
    (Universidad Privada Norbert Wiener, 2018-08-04) Donayre Navarro, María Aurora del Rosario; Purizaca Ramos, Nora Luz; Avila Vargas Machuca, Jeannette Giselle
    Objective: To analyze the evidence on the effectiveness of the Hepatitis B vaccination with an accelerated schedule compared to the standardized schedule for Hepatitis B seroconversion in at-risk populations. Materials and Methods: Observational and retrospective systematic review, the search was restricted to full-text articles, and the selected articles were subjected to critical reading, using the Grade system to assign the strength of recommendation. Results: According to the results obtained from the systematic review, out of a total of 10 articles reviewed, 60% (n=6) demonstrate the efficacy of an accelerated schedule (0,1,2 months) compared to the standardized schedule (0,2,6 months). The studies state that the accelerated vaccination schedule provides high antibody titers in a short time and can be used for high-risk individuals: family members of chronic carriers, healthcare workers, travelers to endemic areas, and individuals with high-risk behaviors in hard-to-reach populations, to overcome the disadvantages of a standardized vaccination schedule with low adherence. Conclusions: The accelerated schedule is more effective compared to the standardized Hepatitis B vaccination schedule in at-risk populations, considering the administration of a booster dose to ensure proper antibody titration. In the country, an accelerated Hepatitis B vaccination schedule (0,1,2 months) is used; however, the reviewed evidence suggests adding a booster dose.