Examinando por Autor "Gamboa Ortiz, Milagros Ruth"

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    Evaluación de la actividad cicatrizante y toxicidad dérmica del gel a base del extracto etanólico de la corteza de Calycophyllum spruceanum (Benth.) Hook. f. ex K. Schum “capirona” en ratas albinas Holtzman
    (Universidad Privada Norbert Wiener, 2021-03-12) Gamboa Ortiz, Milagros Ruth; Miranda Rivera, Estefani Samantha; Chávez Flores, Juana Elvira
    The use of medicinal plants is important due to their low cost. Materials and Method: The plant species was collected in Ucayali, Peru. An ethanolic extraction of the bark of Calycophyllum spruceanum (Benth) Hook. f. ex Schum. was performed. The wound-healing activity was assessed using the Vaisberg et al. technique, for which three gels based on the plant species were prepared at concentrations of 1,2, and 4%. These were compared with two standard groups: a 10% gel (containing plant strain extract, sodium heparin, and allantoin) named "Contratubex," and a control group. Dermal toxicity was determined using the Contero R technique, where a single oral and dermal dose of 5000 mg/kg of the extract was administered to rats. Results: Qualitative analysis determined that the extract is soluble in distilled water and contains primary and secondary metabolites, such as flavonoids and tannins. Regarding wound-healing activity, the 1% concentration gel achieved the highest healing efficacy of 90%. In the toxicological evaluation, no rat showed dermal toxicity. Conclusion: It was determined that the ethanolic extract from the bark of Calycophyllum spruceanum (Benth) Hook. f. ex Schum. does present wound-healing activity in rats and does not possess dermal toxicity via topical administration.