Examinando por Autor "Gomez Vallejos, Mirla Carina"

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    Administration of antituberculosis drugs in fixed doses combined with individualized doses to improve adherence and safety in users affected by pulmonary tuberculosis
    (Universidad Privada Norbert Wiener, 2020-02-29) Gomez Vallejos, Mirla Carina; Aquino Contreras, Cristhian Johan; Bonilla Asalde, César Antonio
    Objective: To systematize the administration of fixed-dose combination drugs compared to the administration of individualized-dose drugs to improve treatment adherence and safety in users affected by pulmonary tuberculosis. Materials and Methods: A systematic, observational, and retrospective review was conducted, with a quantitative approach under an analytical selection, using the Grade evaluation system to determine the level of evidence. The following indexed scientific journals were used as sources: PubMed, ScienceDirect, Scielo, Elsevier. It can be indicated that of the 10 scientific articles reviewed, 70% (n=7/10) are systematic reviews, 20% (n=2/10) are randomized controlled trials, and 10% (n=1/10) are cohort studies. The results obtained in this study came from Spain (30%), followed by France (20%), Brazil (20%), Spain (10%), Australia (10%), and Barcelona (10%). Results: 100% of the scientific article review (n=10/10) indicates that the administration of antituberculosis drugs in combined doses does not present significant differences. Conclusion: The use of fixed-dose combination drugs and individualized doses does not show significance in safety or effectiveness between the groups when the short-term directly observed treatment strategy was used.