Examinando por Autor "Guerrero García, Esther Doris"

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    Interacciones medicamentosas relacionadas a la polifarmacia psiquiátrica en usuarios adultos del Instituto Nacional de Salud Mental de Lima 2021
    (Universidad Privada Norbert Wiener, 2022-10-07) Oropeza Garay, Shulen Liuva; Guerrero García, Esther Doris; Alvarado Chávez, Britt
    Objective: "To determine the relationship between psychiatric polypharmacy and drug interactions in adult users of the National Institute of Mental Health in Lima, 2021." Method: Deductive with a quantitative approach, basic study, non-experimental, descriptive, correlational, retrospective, and cross-sectional. The technique used was observation, and the instrument was a data collection form. Results: The study evaluated 300 medical prescriptions. Of the patients, 51% were aged 18 to 39 years, and 40% were aged 40 to 59 years; 56% were male, and 44% female. Regarding the number of psychotropic drugs prescribed, 86% were prescribed 4 to 5 psychotropic drugs, and 11% were prescribed between 6 and 7. Additionally, 42.3% had indications every 12 hours, and 57.3% had treatments lasting 1 to 2 months. The most prevalent type of polypharmacy was adjuvant polypharmacy (72.7%), followed by total polypharmacy (10.3%) and multiclass polypharmacy (7.7%). The most frequent therapeutic groups were antidepressants (37.7%) and antipsychotics (33.7%). Regarding drug interactions, 51% had 1 to 3 interactions, 35% had 4 to 6 interactions, and 3.3% had more than 10 interactions. Of these, 52.3% were synergistic drug interactions, and 45.7% were pharmacokinetic interactions affecting metabolism. Severe drug interactions were observed in 81% of cases, while 18% were moderate. Regarding documentation, 75.7% presented suspicious or fair evidence, while 12.7% had probable or good evidence. Conclusion: It was determined that there is a significant relationship between psychiatric polypharmacy and drug interactions in adult users of the National Institute of Mental Health in Lima, 2021.