Examinando por Autor "Inche Cabello, Jorge Alberto"

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    Comparación del efecto hipoglucemiante del extracto hidroalcohólico de las hojas Smallanthus Sonchifolius (Poepp) Rob “yacón“ frente a un extracto de libre comercio, en ratones hiperglucémicos
    (Universidad Privada Norbert Wiener, 2015) Bello Sánchez, Vanessa Jaqueline; Inche Cabello, Jorge Alberto; Torres Veliz, Ernesto Raúl
    The hypoglycemic effect of the hydroalcoholic extract of Smallanthus sonchifolius (Poepp.) H. Rob. (“yacón”) leaves and of a commercially available extract was evaluated on blood glucose levels in male and female mice, both normoglycemic and with hyperglycemia induced by oral glucose overload and alloxan, in order to assess their possible hypoglycemic activity. Blood glucose measurements were taken after fasting at 0, 2, 4, 6, and 24 hours. The analysis of results showed that administration of the hydroalcoholic extract of Smallanthus sonchifolius leaves and of the commercial extract in normoglycemic mice did not produce a statistically significant decrease (p > 0.05) in blood glucose levels; only glibenclamide exhibited this effect at 24 hours. In hyperglycemic mice with oral glucose overload, a statistically significant decrease (p < 0.05) in blood glucose levels was observed with administration of both extracts at 6 hours after the initial measurement. Similarly, in alloxan-induced hyperglycemic mice, a statistically significant decrease (p < 0.05) in blood glucose levels was observed 6 hours after treatment. It is concluded that the extract of Smallanthus sonchifolius leaves and the commercial preparation exhibit hypoglycemic activity under induced hyperglycemia, but do not present hypoglycemic effects under normoglycemic conditions.