Examinando por Autor "Martínez Vargas Araníbar, Humberto Nazario"

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  • Miniatura
    PublicaciónAcceso abierto
    Caracterización de interacciones medicamentosas potenciales en las prescripciones médicas atendidas a pacientes ambulatorios
    (Universidad Privada Norbert Wiener, 2015) Arce Tintaya, Abner; Castro Luna, Rosa Chabely; Martínez Vargas Araníbar, Humberto Nazario
    The objective of this study was to determine the characterization of potential drug interactions present in medical prescriptions attended to outpatients at the InkaFarma pharmacy located in Flora Tristán, La Molina district, between April and June 2014. A descriptive, cross-sectional, retrospective, and observational study was designed for this purpose. Medical prescriptions from various specialties were considered. According to the inclusion criteria, 191 medical prescriptions were analyzed. It was found that 67% did not present drug interactions, while 33% did. Regarding sex distribution, 41% of the population were male and 58% female; 35 females and 28 males presented drug interactions. Concerning the onset of interactions, the majority (77%) were undocumented, 18% had a slow onset, and 6% had a rapid onset. Regarding the severity, 81% of the interactions were moderate, 10% were major, and 9% were minor. By mechanism of action, 48% were pharmacodynamic and 37% were pharmacokinetic. Regarding age groups, the majority of the population were adults (83 patients), followed by young people (81 patients). The specialty with the highest number of drug interactions was internal medicine, with 17 cases out of 88 prescriptions attended.
  • Miniatura
    PublicaciónAcceso abierto
    Interacciones medicamentosas potenciales en prescripciones médicas atendidas en el servicio de unidad de terapia intensiva pediatría del Hospital Nacional Docente Madre Niño San Bartolomé durante el periodo de enero–junio del 2014
    (Universidad Privada Norbert Wiener, 2015) Cáceres Manrique, Linda Carol; Quispe Huisa, Diana Lucy; Martínez Vargas Araníbar, Humberto Nazario
    The present study aimed to identify potential drug–drug interactions (pDDIs) in medical prescriptions of polymedicated and hospitalized pediatric patients with a hospital stay longer than two days, during the period January–June 2014, in the Pediatric Intensive Care Unit of the Hospital Nacional Docente Madre Niño San Bartolomé. A descriptive, retrospective, and cross-sectional study was carried out. Data were collected from medical prescriptions, and the study population consisted of 59 patients of both sexes who met the inclusion and exclusion criteria. Of these, 57 patients (96.6%) presented at least one potential drug–drug interaction, while 2 patients (3.4%) did not. A total of 3,486 pDDIs were identified. By sex, 35 patients (59.3%) were male and 24 (40.7%) female. The age group with the highest frequency of pDDIs was children aged 0–3 years (78%). The most frequent interacting drug pairs were midazolam + ranitidine (5.82%), fentanyl + ranitidine (5.76%), fentanyl + midazolam (4.79%), and metoclopramide + midazolam (3.84%), with other interactions accounting for 56.54%. Regarding onset, 88.04% were unspecified/unknown, 6.34% slow, and 5.62% rapid. By severity, 60.1% were moderate, 24.1% major, 13.7% minor, and 2.1% contraindicated. Mechanism analysis showed 52.12% pharmacokinetic and 47.88% pharmacodynamic interactions. Potential drug–drug interactions were analyzed using drug interaction databases and bibliographic references (Micromedex, Drugs.com, Medscape).