Examinando por Autor "Moya-Salazar, Jeel"
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Publicación Acceso abierto A bibliometric analysis of 47-years of research on public health in Peru(Modestum LTD, 2023-03-21) Sevillano-Jimenez, Javier; Carrión-Chambilla, Mario; Espinoza-Lecca, Eduardo; Mori-Quispe, Elizabeth; Contreras-Pulache, Hans; Moya-Salazar, Jeel“Objectives: To measure Peruvian scientific production on public health in Scopus database. Methods: Bibliometric study using advanced Scopus web search engine (https://www.scopus.com/search/ form.uri?display=advanced). The inclusion criteria were the publications of articles related to public health between 1973 and 2020. The equation was used as a strategy: TITLE-ABS-CLAVE (“public health”) AND AFFILCOUNTRY (Peru) AND (EXCLUDE (PUBYEAR, 2021) OR EXCLUDE (PUBYEAR, 2020)). SCImago journal & country rank was used to determine the impact factor (h-index) and the quartile of the journals identified. The analysis included in SPSS v24.0 included years of publication, institutions, h-index, list of authors with the most publications, publication types, and journals. Results: 903 articles published by 7.5±12.5 authors were included, showing that 74.5% were original articles written mainly in English (77.7%). The publications for the year 1973 and 2019 were 3 (0.3%) and 98 (10.9%), respectively. In addition, it was shown that the most productive institutions were the Universidad Peruana Cayetano Heredia (42.9%) and the Universidad Nacional Mayor de San Marcos (13.1%). The journal with the highest number of Peruvian publications was Revista Peruana de Medicina Experimental y Salud Pública (RPMESP) [Peruvian Journal of Experimental Medicine and Public Health (PJEMPH)] (17.5%) and PLoS ONE (2.88%). Conclusions: The present study showed in the magazines with the highest number of citations and therefore greater visualization, where Peruvian publications in this area were published, with this the future readers can take these magazines into consideration so that their publications have a greater visualization. In addition to this, the study shows the largest institutions that have a great impact on Peruvian publications in public health in Scopus, this invites researchers to analyze the research methodologies that these institutions follow in order to disclose them for reproduction in new entities interested in research.“Publicación Acceso abierto A systematic review of mental health in rural Andean populations in Latin America during the COVID-19 pandemic(Frontiers Media SA, 2023-08-17) Moya-Salazar, Jeel; Jaime-Quispe, Alexis; Cañari, Betsy; Moya-Espinoza, Jeel G.; Contreras-Pulache, Hans“Background: COVID-19 has been causing mental health problems around the world, with rural and indigenous peoples likely to be the most aected. This systematic review synthesizes and critically analyzes the existing literature on mental disorders in the rural Andean population in Latin America. Methods: A systematic review with narrative synthesis was carried out following the PRISMA guidelines. We searched nine databases (PubMed/MEDLINE, Scopus, EMBASE, ScienceDirect, Web of Science, Cochrane, Scielo, LILACS, and Latindex), five public prepublication servers (SocArXiv, medRxiv, bioRxiv, SportRXiv, and Preprints), ALICIA, and Google Scholar for articles that included the analysis of mental health problems using data collected from the rural Andean population in Latin America. These were eligible for inclusion. Articles that included NonLatin American populations (including European or African migrants) and studies conducted prior to the COVID-19 pandemic (since the declaration of national lockdown) were excluded. Results: A total of 23,761 articles were retrieved, 14 of which met the inclusion requirements. Most were cross-sectional (n = 12) and related to anxiety (n = 9), depression (n = 8), and stress (n = 5). The mental health analysis of 5,976 rural dwellers from four countries in Latin America also included gray literature studies (n = 7) that allowed the quantification of mental health problems in adults (n = 7) and adolescents/children (n = 4). Only one study was multinational, and the quality of publications varied. Despite the high frequency of anxiety, depression, and stress symptoms among rural Latin American populations during COVID-19, published research is very limited. This review found preliminary evidence that the frequency of anxiety (45%), depression (27.6%), and stress (33.1%) in the rural population was associated with pandemic restrictions across countries. Measures of other psychiatric problems, such as distress or suicidal ideation, cannot be estimated. Conclusion: Regional-wide studies investigating changes in the frequency of symptoms of mental health problems in the context of the COVID-19 pandemic are warranted to inform culturally adapted prevention strategies. This study is limited to a narrative synthesis and may be subject to publication bia“Publicación Acceso abierto Actitudes del autocuidado de pacientes con tuberculosis en enfermeros peruanos luego de un brote hospitalario(Editorial Ciencias Medicas, 2023-06) Siesquen, Jessica J.; Moya-Salazar, Jeel; Ubidia-Incio, Roberto; Rojas-Zumaran, Víctor; Moya-Salazar, Belén; Contreras-Pulache, Hans“Introducción: La tuberculosis es una de las principales causas de morbimortalidad en todo el mundo. Las medidas de prevención son clave para evitar su propagación y el contagio entre profesionales de salud. Objetivo: Determinar las actitudes del autocuidado sobre la tuberculosis en el personal de enfermería luego de un brote infeccioso hospitalario. Métodos: Estudio transversal, en personal de enfermería (n= 94; personal técnico n= 44; 46,8 %). Se incluyó al personal de enfermería voluntario > 18 años, de ambos sexos, que trabaje en el Departamento de Emergencia. Se usó el cuestionario de 15 ítems de Valle (2017), para estimar los conocimientos y actitudes sobre el autocuidado, 3 dimensiones: prevención, diagnóstico y tratamiento de la tuberculosis. Resultados: El promedio de edad de los participantes fue de 44,7 ± 8,8 años, el 88,3 % mujeres y el tiempo promedio de trabajo fue 11,2 ± 7,8 años. Se hallaron diferencias entre los años de servicio, entre los técnicos (8,55 ± 7,94 años) y profesionales (13,48 ± 6,98 años) (p< 0,001). El 100 % presentaron actitudes de aceptación del autocuidado en todas las dimensiones. El 4,5 % y el 27,3 % de técnicos presentaron actitudes de indiferencia en la dimensión diagnóstico y tratamiento de tuberculosis (p= 0,001). Conclusiones: Existen actitudes favorables en el personal de enfermería sobre autocuidado de la tuberculosis luego de un brote en un hospital de Lima, aunque en técnicos de enfermería se reportan actitudes de indiferencia en el diagnóstico y tratamiento de tuberculosis.“Publicación Acceso abierto “Alteraciones citogenéticas en pacientes con diagnóstico de infertilidad en Lima, Perú “(Sociedad Chilena de Obstetricia y Ginecologia, 2022-06-09) Moya-Salazar, Jeel; Vega-Vera, Rafael; Rojas-Zumaran, Víctor; Contreras-Pulache, Hans“Introducción: La infertilidad es una enfermedad multicausal y el componente genético representa uno de sus principales eventos. Si bien la distribución de la infertilidad puede variar entre poblaciones, las parejas de los países con bajos y medianos ingresos pueden verse más afectadas por la infertilidad, con una proporción de alteraciones citogenéticas aún no esclarecidas. Objetivo: Evaluar la frecuencia de alteraciones citogenéticas y su correlación con el número de abortos en pacientes peruanas con diagnóstico de infertilidad. Método: Se realizó un estudio de corte transversal en 400 pacientes de 18 a 60 años, de ambos sexos, con diagnóstico de infertilidad. Se registraron las características clínicas disponibles durante el examen genético y el análisis citogenético convencional fue con bandeo GTG en muestras de sangre periférica. El análisis de correlación se realizó con la prueba de Spearman. Resultados: Del total, 389 pacientes cumplieron los criterios de inclusión, y de estos, 169 (43,44%) tuvieron reportes de abortos (promedio: 2,25, rango: 1-7). Hallamos una correlación significativa ente el número de abortos y las alteraciones citogenéticas (p < 0,000). Reportamos 25/289 (6,43%) alteraciones cromosómicas, de las que 11/25 (44%) fueron heterocromatinas constitutivas y 6/25 (24%) fueron translocaciones reciprocas. Las alteraciones citogenéticas más frecuentes fueron 16qh+ y 9qh+ (ambas con un 16%), y afectaron a 17 (68%) varones. Conclusiones: Existe una moderada frecuencia de alteraciones citogenéticas en pacientes peruanos con diagnóstico de infertilidad, y las alteraciones más frecuentes fueron heterocromatina constitutivas. Además, evidenciamos una correlación significativa ente el número de abortos y las alteraciones citogenéticas.“Publicación Acceso abierto Alterations in the coagulation markers did not show differences with the severity of COVID-19 in Peruvian patients: A cross-sectional single-center study(HEALTH SCIENCE REPORTS, 2023-03-15) Moya-Salazar, Jeel; Cóndor, Liliana Y.; Zuñiga, Nahomi; Jaime-Quispe, Alexis; Moya-Salazar, Jeel; Chicoma-Flores, Karina; Cañari, Betsy; Contreras-Pulache, HansBackground and Aims:COVID‐19 is a pandemic disease that can lead to alteredlung function, systemic inflammatory events, and altered coagulation. During severestages of the disease, changes in coagulation homeostasis increase, leading tothrombosis, and increased risk of death. In this cross‐sectional study, we aimedto assess coagulation markers by COVID‐19 severity in Peruvian adults.Methods:During the second wave of infections, we included 186 adults diagnosedwith COVID‐19 (mean age 53.3 ± 16.3 years). Patients were divided into mild,moderate, and severe stages of COVID‐19, and coagulation markers includedprothrombin time (PT), activated partial prothrombin time (aPTT), fibrinogen,D‐dimer, and platelet count.Results:Of the total, 120 (64.5%) were males and 39 (21%) were in the intensivecare unit. We determine 104 (55.9%), 43 (24.7%), and 36 (19.4%) patients in mild,moderate, and severe stages of COVID‐19, respectively. In the severe stage ofCOVID‐19, patients had an average concentration of PT, aPTT, fibrinogen,D‐dimer,and platelets of 13.2 ± 0.9 s, 28.9 ± 4.3 s, 679.4 ± 185.1 mg/dL, 1.9 ± 3.1 μg/mL, and272.8 ± 88.9 cel/10 mm,3respectively. We found no differences in the concentra-tion of each marker according to severity (p< 0.05). Patients with severe COVID‐19had altered the aPTT, fibrinogen,D‐dimer, and PT in 31 (57.4%), 48 (88.9%), 37(68.5%), and 15 (27.8%) cases, respectively.Conclusions:Our results showed that although there is an alteration in coagulationmarkers, mainly fibrinogen andD‐fiber, there are no differences in concentrationaccording to the severity of COVID‐19Publicación Acceso abierto Aproximaciones sobre el acto de mirar: la peste de Azoth(Editorial Ciencias Medicas, 2023) Moya-Salazar, Jeel; Contreras-Pulache, HansLas neurociencias contemporáneas continúan separando el acto de ver en los procesos de la visión y los procesos de la motricidad ocular, sin plantear aun una explicación unificadora de ambos en una misma realidad: como el acto de mirar. El objetivo del presente artículo es explicar este acto a través de la serie de eventos neurológicos que suceden y entender que se mira con la conciencia. Se explican los procesos visuales en base al enfoque neurocientífico contemporáneo y la Teoría Sociobiológica Informacional en “La Peste de Azoth“ de Nicolas Poussin. Mientras que la explicación tradicional de la neurociencia refiere que todo estímulo activa un receptor, siguiendo una vía nerviosa hasta el cerebro, desde la Teoría Sociobiológica Informacional, el acto de mirar es una actividad epiconsciente, una construcción que resulta de la suma emergente de los cinco niveles de complejidad. Estos integran este proceso en los movimientos que describen los ojos y la acción de lo que se mira simultáneamente. “La Peste de Azoth“ muestra una ciudad azotada por la peste bubónica, con dos rasgos: maldición divina y presencia de miasmas respirables. Poussin no solo pintó los motivos de una explicación mágica (tradicional) y científica, sino también de una explicación tecnológica (bacteriológica) que emergería dos siglos después de su muerte. En conclusión, el acto de mirar desde la Teoría Sociobiológica Informacional, es un proceso que principian en el neocortex y que integra la información en cinco niveles. Esta explicación permite entender La Peste de Azoth“ como un enfoque tecnológico adelantado.Publicación Acceso abierto Can living with COVID-19 patients in a hospital increase anxiety levels? A survey-based single-center study in Peru(Modestum LTD, 2022-02-25) Moya-Salazar, Jeel; Saciga-Saavedra, Walter; Cañari, Betsy; Chicoma-Flores, Karina; Contreras-Pulache, Hans“Introduction: Anxiety can affect front-line healthcare workers (HCWs) during the COVID-19 pandemic mainly in settings with influencing factors. Living with COVID-19 patients in hospital settings could affect mental health during lockdown. The present study aimed to estimate the anxiety levels of HCWs of the care center for COVID-19 Villa Panamericana during the first outbreak of COVID-19 in Peru. Methods: This is a descriptive and correlational study. Ninety-six HCWs were enrolled in this study (mean age 30±5.6 years). The care center for COVID-19 Villa Panamericana houses COVID-19 patients and HCWs in the same environment. We used the 14-item Hamilton anxiety rating scale questionnaire. Professionals were interviewed directly at the VP-19 rest towers. SPSS V.23 were used to analyze the data. Results: Fifty-four (56.3%) were male and the most frequent age group was 26-35 years (81.3%). Thirty-nine (40.6%) were nurses, 28 (29.2%) were nursing technicians, 15 (15.6%) were physicians, and 14 (14.6%) were medical technologists. Of the total, 66 (68.8%) HCWs had a mild level of anxiety, while 6 (6.3%) had severe anxiety. Medical technologists and nursing technicians had the highest level of severe anxiety (14.3% and 7.1%), while nurses had the highest level of mild anxiety (76.9%). We report that 32 (33.3%) HCWs had COVID-19 while 93.7% had symptoms of anxiety [3(9.4%) mild to moderate, 21(65.6 %) moderate to severe, and 6(18.8%) severe]. We found a significant difference in anxiety levels between HCWs with and without COVID-19 (p=0.001). Conclusions: Levels of moderate and severe anxiety significantly increased in HCWs infected with COVID-19 during their coexistence with COVID-19 patients in the health center that houses both at the same time.“Publicación Acceso abierto Can living with COVID-19 patients in a hospital increase anxiety levels? A survey-based single-center study in Peru(Modestum LTD, 2022-06-03) Moya-Salazar, Jeel; Saciga-Saavedra, Walter; Cañari, Betsy; Chicoma-Flores,Karina; Contreras-Pulache, Hans“Introduction: Anxiety can affect front-line healthcare workers (HCWs) during the COVID-19 pandemic mainly in settings with influencing factors. Living with COVID-19 patients in hospital settings could affect mental health during lockdown. The present study aimed to estimate the anxiety levels of HCWs of the care center for COVID-19 Villa Panamericana during the first outbreak of COVID-19 in Peru. Methods: This is a descriptive and correlational study. Ninety-six HCWs were enrolled in this study (mean age 30±5.6 years). The care center for COVID-19 Villa Panamericana houses COVID-19 patients and HCWs in the same environment. We used the 14-item Hamilton anxiety rating scale questionnaire. Professionals were interviewed directly at the VP-19 rest towers. SPSS V.23 were used to analyze the data. Results: Fifty-four (56.3%) were male and the most frequent age group was 26-35 years (81.3%). Thirty-nine (40.6%) were nurses, 28 (29.2%) were nursing technicians, 15 (15.6%) were physicians, and 14 (14.6%) were medical technologists. Of the total, 66 (68.8%) HCWs had a mild level of anxiety, while 6 (6.3%) had severe anxiety. Medical technologists and nursing technicians had the highest level of severe anxiety (14.3% and 7.1%), while nurses had the highest level of mild anxiety (76.9%). We report that 32 (33.3%) HCWs had COVID-19 while 93.7% had symptoms of anxiety [3(9.4%) mild to moderate, 21(65.6 %) moderate to severe, and 6(18.8%) severe]. We found a significant difference in anxiety levels between HCWs with and without COVID-19 (p=0.001). Conclusions: Levels of moderate and severe anxiety significantly increased in HCWs infected with COVID-19 during their coexistence with COVID-19 patients in the health center that houses both at the same time.“Publicación Acceso abierto Changes in High-Density Lipoprotein (HDL), Low-Density Lipoprotein (LDL) and Cholesterol Concentration in Heavy Cannabis Users: A Single-Centre Study in Cusco, Peru(MDPI, 2022-08-12) Cusihuaman, Sandro; Moya-Salazar, Jeel; Wong-Salgado, Pedro; Moya-Salazar, Marcia M.; Cañari, Betsy; Chicoma-Flores, Karina; Contreras-Pulache, Hans“Background: The effect of cannabis on cholesterol and lipid balance has been reported for decades. However, there are conflicting reports on the reduction of low-density lipoprotein (LDL-C) and total cholesterol. The purpose of this study was to determine the immediate changes of Cannabis spp. consumption by pyrolytic route in heavy users. Methods: A cross-sectional study on 20 Peruvian heavy cannabis users (mean age: 31 ± 9.5 years). The inclusion criteria were males with an average weight of 50–70 kg, normal BMI, and having used cannabis, without association with other drugs, for at least one year with a high frequency per week (use: 4–7 days/week). High-density lipoprotein (HDL-C), LDL-C, and total cholesterol were evaluated 30 and 120 min after the administration of Cannabis spp. (~0.2 g by inhalation). Results: Of the total 12 (60%), 10 (50%), and 11 (55%) had desirable total cholesterol, fairly good HDL-C (40–60 mg/dL) and fairly good LDL-C (100–129 mg/dL) values, respectively. The mean basal concentration of total cholesterol, HDL-cholesterol, and LDL-cholesterol was 193.37 ± 20.18 mg/dL, 60.05 ± 6.36 mg/dL, and 129.65 ± 14.50 mg/dL, respectively. HDL-cholesterol showed progressive increases in participants with desirable HDL-C > 60 mg/dL at 30 min (10 vs. 14 participants, p < 0.001) and at 120 min (10 vs. 16 participants, p < 0.001), while LDL-C peaked in participants with concentrations <100 mg/dL at 30 min (desirable cholesterol: 0 vs. 2, p = 0.001). HDL-C concentration showed differences after cannabis consumption, showing increases at 30 (63.25 ± 7.68 mg/dL) and 120 min (69.15 ± 18.67 mg/dL) and total cholesterol concentration changed to 180.95 ± 19.3 mg/dL (95%CI 172.5 to 189.4) at 120 min (p = 0.007). Conclusions: HDL-C cholesterol increased 30 and 120 min after Cannabis spp. ingestion, while LDL-C and total cholesterol showed partial reductions in heavy-users from Cusco, Peru.“Publicación Desconocido Changes in High-Density Lipoprotein (HDL), Low-Density Lipoprotein (LDL) and Cholesterol Concentration in Heavy Cannabis Users: A Single-Centre Study in Cusco, Peru(MDPI, 2022-08-12) Cusihuaman , Sandro; Moya-Salazar, Jeel; Wong-Salgado, Pedro; Moya-Salazar, Marcia M.; Cañari, Betsy; Chicoma-Flores , Karina; Contreras-Pulache, Hans“Background: The effect of cannabis on cholesterol and lipid balance has been reported for decades. However, there are conflicting reports on the reduction of low-density lipoprotein (LDL-C) and total cholesterol. The purpose of this study was to determine the immediate changes of Cannabis spp. consumption by pyrolytic route in heavy users. Methods: A cross-sectional study on 20 Peruvian heavy cannabis users (mean age: 31 ± 9.5 years). The inclusion criteria were males with an average weight of 50–70 kg, normal BMI, and having used cannabis, without association with other drugs, for at least one year with a high frequency per week (use: 4–7 days/week). High-density lipoprotein (HDL-C), LDL-C, and total cholesterol were evaluated 30 and 120 min after the administration of Cannabis spp. (~0.2 g by inhalation). Results: Of the total 12 (60%), 10 (50%), and 11 (55%) had desirable total cholesterol, fairly good HDL-C (40–60 mg/dL) and fairly good LDL-C (100–129 mg/dL) values, respectively. The mean basal concentration of total cholesterol, HDL-cholesterol, and LDL-cholesterol was 193.37 ± 20.18 mg/dL, 60.05 ± 6.36 mg/dL, and 129.65 ± 14.50 mg/dL, respectively. HDL-cholesterol showed progressive increases in participants with desirable HDL-C > 60 mg/dL at 30 min (10 vs. 14 participants, p < 0.001) and at 120 min (10 vs. 16 participants, p < 0.001), while LDL-C peaked in participants with concentrations <100 mg/dL at 30 min (desirable cholesterol: 0 vs. 2, p = 0.001). HDL-C concentration showed differences after cannabis consumption, showing increases at 30 (63.25 ± 7.68 mg/dL) and 120 min (69.15 ± 18.67 mg/dL) and total cholesterol concentration changed to 180.95 ± 19.3 mg/dL (95%CI 172.5 to 189.4) at 120 min (p = 0.007). Conclusions: HDL-C cholesterol increased 30 and 120 min after Cannabis spp. ingestion, while LDL-C and total cholesterol showed partial reductions in heavy-users from Cusco, Peru.“Publicación Acceso abierto Clinical, Phenotypic, and Demographic Characteristics of Peruvian Children and Neonates with Autosomal and Sex Chromosome Aneuploidies(AVES, 2023-02-28) Moya-Salazar, Jeel; Rojas-Zumaran, Víctor; Vega-Vera, Rafael; Espinoza-Lecca, Eduardo; Contreras-Pulache, Hans“Objective: Autosomal and sex chromosome aneuploidies are associated with multiple risk factors that determine their frequency and their social and health impact. We aimed to determine the clinical, phenotypic, and demographic characteristics of Peruvian children and neonates with autosomal and sex chromosome aneuploidies. Materials and Methods: This was a retrospective study conducted on 510 pediatric patients. We conducted a cytogenetic analysis with G-bands by trypsin using Giemsa (GTG) banding, and the results were reported using the International System for Cytogenetics Nomenclature 2013 system. Results: Of 399 children (mean age 2.1 ± 4 years), 84 (16.47%) had aneuploidies, with 86.90% being autosomal (73.81% trisomies). In autosomal aneuploidies, 67.85% (n=57) of the children had Down syndrome where the most common cause was free trisomy 21 (52 cases, 61.91%), followed by Robertsonian translocation (4 cases, 4.76%). Edwards and Patau syndrome affected 4 (4.76%) and 1 (1.19%) neonate. The most frequent phenotypic characteristics in children with Down syndrome were Down syndrome-like facies (45.61%) and macroglossia (19.29%). Of sex chromosome aneuploidies, 6/7 were abnormalities of the X chromosome (mainly 45,X). Neonate’s age (19 ± 44.9 months), paternal age (49 ± 9 years), height (93.4 ± 176 cm), and gestational age (30 ± 15.4 weeks) were significantly correlated with the presence of sex chromosome and autosomal aneuploidies (P < .001; P=.025; and P=.001). Conclusions: Down syndrome and Turner’s syndrome were the most frequent aneuploidy and sex chromosome aneuploidy, respectively. In addition, some of the clinical, phenotypic, and demographic characteristics, such as newborn’s age, paternal age, gestational age, and height, were significantly correlated with the occurrence of aneuploidy. In this sense, these characteristics could be considered risk factors among this population.“Publicación Acceso abierto Clinical, Phenotypic, and Demographic Characteristics of Peruvian Children and Neonates with Autosomal and Sex Chromosome Aneuploidies(AVES, 2023-02-28) Moya-Salazar, Jeel; Rojas-Zumaran, Víctor; Vega-Vera, Rafael; Espinoza-Lecca, Eduardo; Contreras-Pulache, Hans“Objective: Autosomal and sex chromosome aneuploidies are associated with multiple risk factors that determine their frequency and their social and health impact. We aimed to determine the clinical, phenotypic, and demographic characteristics of Peruvian children and neonates with autosomal and sex chromosome aneuploidies. Materials and Methods: This was a retrospective study conducted on 510 pediatric patients. We conducted a cytogenetic analysis with G-bands by trypsin using Giemsa (GTG) banding, and the results were reported using the International System for Cytogenetics Nomenclature 2013 system. Results: Of 399 children (mean age 2.1 ± 4 years), 84 (16.47%) had aneuploidies, with 86.90% being autosomal (73.81% trisomies). In autosomal aneuploidies, 67.85% (n=57) of the children had Down syndrome where the most common cause was free trisomy 21 (52 cases, 61.91%), followed by Robertsonian translocation (4 cases, 4.76%). Edwards and Patau syndrome affected 4 (4.76%) and 1 (1.19%) neonate. The most frequent phenotypic characteristics in children with Down syndrome were Down syndrome-like facies (45.61%) and macroglossia (19.29%). Of sex chromosome aneuploidies, 6/7 were abnormalities of the X chromosome (mainly 45,X). Neonate’s age (19 ± 44.9 months), paternal age (49 ± 9 years), height (93.4 ± 176 cm), and gestational age (30 ± 15.4 weeks) were significantly correlated with the presence of sex chromosome and autosomal aneuploidies (P < .001; P=.025; and P=.001). Conclusions: Down syndrome and Turner’s syndrome were the most frequent aneuploidy and sex chromosome aneuploidy, respectively. In addition, some of the clinical, phenotypic, and demographic characteristics, such as newborn’s age, paternal age, gestational age, and height, were significantly correlated with the occurrence of aneuploidy. In this sense, these characteristics could be considered risk factors among this population.“Publicación Acceso abierto Confluent cavitated nodules in invasive mucinous adenocarcinoma: A case report(Modestum LTD, 2023-04-03) López-Hinostroza, Madaleine; Dávila, Juan; Asencio, Angélica Y.; Moya-Salazar, Jeel“Invasive mucinous adenocarcinoma is a rare variant of lung adenocarcinoma. Here, we present the case of a patient with invasive mucinous adenocarcinoma with cavitary lung lesions. A 61-year-old painter-and-bricklayer. She was admitted due to mMRC2 dyspnea, a dry cough that during hospitalization mobilizes dense, abundant secretions, and becomes demanding. Differential diagnoses were made based on clinical symptoms and images, performing multiple laboratory tests ruling out immunosuppression, and two video-bronchofibroscopies finding the diagnosis in the transbronchial lung biopsy: Invasive mucinous adenocarcinoma that would explain the abundant bronchorrhea, advanced stage and poor prognosis led to ventilatory failure and death of the patient.“Publicación Acceso abierto “Confluent cavitated nodules in invasive mucinous adenocarcinoma: A case report“(Modestum LTD, 2023-06-20) López-Hinostroza, Madaleine; Dávila, Juan; Asencio, Angélica Y.; Moya-Salazar, JeelInvasive mucinous adenocarcinoma is a rare variant of lung adenocarcinoma. Here, we present the case of a patient with invasive mucinous adenocarcinoma with cavitary lung lesions. A 61-year-old painter-and-bricklayer. She was admitted due to mMRC2 dyspnea, a dry cough that during hospitalization mobilizes dense, abundant secretions, and becomes demanding. Differential diagnoses were made based on clinical symptoms and images, performing multiple laboratory tests ruling out immunosuppression, and two video-bronchofibroscopies finding the diagnosis in the transbronchial lung biopsy: Invasive mucinous adenocarcinoma that would explain the abundant bronchorrhea, advanced stage and poor prognosis led to ventilatory failure and death of the patientPublicación Acceso abierto Cost and pollution by the use of xylene in cervical cytology in four Peruvian hospitals(Science and Information Organization, 2022-06-08) Moya-Salazar, Jeel; Salazar-Hernández, Richard; Rojas-Zumaran, Victor; Cruz-Gonzales, Gloria; Contreras-Pulache, Hans“Background: Cytological samples are cleared with xylene in two or three baths during a Pap test, however, this solvent has a high degree of toxicity, and being a controlled reagent infers high costs for its purchase and implications for environmental pollution. We estimated the impact of xylene during the Pap test in terms of the number of liters and cost of two baths of xylene, and also estimated the impact with three baths Methods: This cross-sectional study was carried out in four hospitals of EsSalud in Peru in two stages. First, the analysis of the impact due to the use of two baths of xylene was conducted during the period 2015–2019, and second, the estimates were calculated based on the assumption of three baths of xylene for the years 2020–2025. The assumption was based on the recommendations of the 2018 EsSalud cytology guideline. The monthly amount of xylene was ~10 liters per bath/month and the cost per liter was estimated at 8.13 USD (27 soles). Results: For the staining of 594,898 cytology tests, 7,848 liters of xylene were necessary, resulting in a cost of 60,861 USD (202,068 soles) during the period 2015–2019. The estimates showed a maximum assumption of 9,483 liters and 77,110 USD (256,040 soles) for the use of three baths of xylene in the four EsSalud hospitals (p = 0.0025) during the period 2020–2025. Conclusions: We determined that there was a high economic impact of using xylene with two baths from 2015 to 2019 and a dramatic increase in costs with the possible use of three baths of xylene in the Pap test for the following five years.“Publicación Acceso abierto COVID-19 may lower quality of life when infections and deaths increase: A longitudinal study in the Peruvian jungle(Frontiers Media S.A., 2023-03-28) Moya-Salazar, Jeel; Villareal, Chris A.; Cañari, Betsy; Moya-Salazar, Belén; Chicoma-Flores, Karina; Contreras-Pulache, Hans“Background: Quality of life (QoL) is a multifactorial concept on the perception of the individual’s wellbeing underpinned by environmental, psychological, and physical factors. Several studies have shown changes in QoL in the COVID-19 pandemic and may be due to increases in mortality rates, however, no study has investigated this among Peruvian jungle dwellers. Here, we have sought to estimate the QoL of individuals before and after the increase in cases and deaths from COVID-19. Methods: A questionnaire-based longitudinal study was conducted in 102 inhabitants (mean 40.75 ± 7.49 years). The Spanish version of the WHOQOL-BREF was used in two stages: April and June. The first stage was accomplished before the first confirmed case of COVID-19, and the second stage was when the daily mortality rate was 3.5% with an incidence of 87%. Results: Sixty (54.8%) participants were women, 67 (61.9%) were >31 years, and 38 (34.5%) and 32 (29.1%) participants had primary and secondary education, respectively. In the first and second stage we obtained an overall mean QoL of 46.65 ± 23.2 and 35 ± 27.7 points, respectively. Individuals had significantly lower QoL in the face of increased deaths in physical (p = 0.001), mental (p = 0.028) and environmental (p = 0.001) health domains, with the latter having the greatest impact (51.84 ± 5.81 vs. 16.66 ± 5.55 points). Conclusion: Quality of life of Peruvian jungle dwellers is reduced during periods of increased mortality and incidence by COVID-19. Preventive strategies aimed at reducing the impact of COVID-19 on the mental health and global wellbeing of individuals living in the Amazon are recommended to Peruvian authorities.“Publicación Acceso abierto COVID-19 may lower quality of life when infections and deaths increase: A longitudinal study in the Peruvian jungle(Frontiers Media S.A., 2023-03-28) Moya-Salazar, Jeel; Villareal, Chris A.; Cañari, Betsy; Moya-Salazar, Belén; Chicoma-Flores, Karina; Contreras-Pulache, Hans“Background: Quality of life (QoL) is a multifactorial concept on the perception of the individual’s wellbeing underpinned by environmental, psychological, and physical factors. Several studies have shown changes in QoL in the COVID-19 pandemic and may be due to increases in mortality rates, however, no study has investigated this among Peruvian jungle dwellers. Here, we have sought to estimate the QoL of individuals before and after the increase in cases and deaths from COVID-19. Methods: A questionnaire-based longitudinal study was conducted in 102 inhabitants (mean 40.75 ± 7.49 years). The Spanish version of the WHOQOL-BREF was used in two stages: April and June. The first stage was accomplished before the first confirmed case of COVID-19, and the second stage was when the daily mortality rate was 3.5% with an incidence of 87%. Results: Sixty (54.8%) participants were women, 67 (61.9%) were >31 years, and 38 (34.5%) and 32 (29.1%) participants had primary and secondary education, respectively. In the first and second stage we obtained an overall mean QoL of 46.65 ± 23.2 and 35 ± 27.7 points, respectively. Individuals had significantly lower QoL in the face of increased deaths in physical (p = 0.001), mental (p = 0.028) and environmental (p = 0.001) health domains, with the latter having the greatest impact (51.84 ± 5.81 vs. 16.66 ± 5.55 points). Conclusion: Quality of life of Peruvian jungle dwellers is reduced during periods of increased mortality and incidence by COVID-19. Preventive strategies aimed at reducing the impact of COVID-19 on the mental health and global wellbeing of individuals living in the Amazon are recommended to Peruvian authorities.“Publicación Acceso abierto Depression in healthcare workers from the COVID-19 Care and Isolation Center - Villa Panamericana: a single-center prospective study in Peru(NLM (Medline), 2022-04-13) Moya-Salazar, Jeel; Saciga-Saavedra, Walter; Cañari, Betsy; Contreras-Pulache, HansObjective: Depression is a mental problem that affects the well-being of healthcare workers, impacting the quality of care and even leading to commit suicide. We aim to the levels of depression in frontline healthcare workers during the first severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak in Peru. Methods: A prospective cohort study was designed in the coronavirus disease 2019 (COVID-19) Care and Isolation Center – Villa Panamericana in eastern Lima. Care and Isolation Center-Villa Panamericana houses about 150 healthcare workers and COVID-19 patients. The Montgomery-Asberg Depression Rating scale was used for depression assessment. Results: A total of 96 participants (30±5.6 years) were analyzed: 15 (15.6%) physicians, 39 (40.6%) nurses, 14 (14.6%) medical technologists, and 28 (29.2%) nurse technicians. Mild, moderate, and severe depression were present in 35 (36.5%), 44 (45.8%), and 9 (9.4%) of the cases, respectively. The physicians and nurses reported more severe levels of depression: 8 (53.3%) physicians and 18 (46.2%) nurses presented moderate depression; and 2 (13.3%) physicians and 3 (7.7%) nurses presented severe depression (p=0.005). This study determined greater symptoms of depression according to years of work (p=0.001). Thirty-two healthcare workers had COVID-19, 4 (12.5%) physicians, 9 (28.1%) nurses, 7 (21.9%) medical technologists, and 12 (37.5%) nurse technicians. Twenty-four (75%) participants showed symptoms of COVID-19 and developed moderate (12 [37.5%]) and severe (3 [9.4%]) symptoms of depression (p=0.041). Conclusion: This study clearly demonstrated a high prevalence of depression in the Care and Isolation Center-Villa Panamericana frontline healthcare workers during the COVID-19 pandemic in Peru.Publicación Acceso abierto Depression in healthcare workers from the COVID-19 Care and Isolation Center - Villa Panamericana: a single-center prospective study in Peru(INST ISRAELITA ENSINO & PESQUISA ALBERT EINSTEIN, 2022-04-13) Moya-Salazar, Jeel; Saciga-Saavedra, Walter; Cañari, Betsy; Contreras-Pulache, Hans“Objective Depression is a mental problem that affects the well-being of healthcare workers, impacting the quality of care and even leading to commit suicide. We aim to the levels of depression in frontline healthcare workers during the first severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak in Peru. Methods A prospective cohort study was designed in the coronavirus disease 2019 (COVID-19) Care and Isolation Center – Villa Panamericana in eastern Lima. Care and Isolation Center-Villa Panamericana houses about 150 healthcare workers and COVID-19 patients. The Montgomery-Asberg Depression Rating scale was used for depression assessment. Results A total of 96 participants (30±5.6 years) were analyzed: 15 (15.6%) physicians, 39 (40.6%) nurses, 14 (14.6%) medical technologists, and 28 (29.2%) nurse technicians. Mild, moderate, and severe depression were present in 35 (36.5%), 44 (45.8%), and 9 (9.4%) of the cases, respectively. The physicians and nurses reported more severe levels of depression: 8 (53.3%) physicians and 18 (46.2%) nurses presented moderate depression; and 2 (13.3%) physicians and 3 (7.7%) nurses presented severe depression (p=0.005). This study determined greater symptoms of depression according to years of work (p=0.001). Thirty-two healthcare workers had COVID-19, 4 (12.5%) physicians, 9 (28.1%) nurses, 7 (21.9%) medical technologists, and 12 (37.5%) nurse technicians. Twenty-four (75%) participants showed symptoms of COVID-19 and developed moderate (12 [37.5%]) and severe (3 [9.4%]) symptoms of depression (p=0.041). Conclusion This study clearly demonstrated a high prevalence of depression in the Care and Isolation Center-Villa Panamericana frontline healthcare workers during the COVID-19 pandemic in Peru.“Publicación Acceso abierto “Detection of Helicobacter pylori in faeces of children of rural human settlements: An exploratory study in Peru“(MODESTUM LTD, 2022-09-03) Moya-Salazar, Jeel; Manrique, Flor de María; Loayza, Cristhina; Laopa, Karla V.; Moya-Salazar, Jeel; Rojas-Zumaran, Víctor“Introduction: Helicobacter pylori is one of the major infectious agents in low-income countries, and its clinical characteristics are unknown in many populations. Children are a susceptible population and can contract these pathogens through contaminated food and water. Objectives: To determine the presence of Helicobacter pylori in children under eight years of age of rural human settlements in Peru. Methods: This exploratory study was conducted with 25 child volunteers authorized by the parents for their evaluation, without precedent of any apparent clinical manifestation. Antigen detection of H. pylori in faeces by a rapid assay onsite H. pylori Ag. Rapid test according to the manufacturer’s requirements. Has been evaluated the social determinants related to possible infection. Results: The average age (2±1.8 years) of 14 girls was different from the average age (2.7±2.2 years) of 11 boys included in the study (p=0.010). Of the total we determinate nine (36%) positive tests, which mainly affected boys (five patients 20%) under two years of age (six patients, 24%). In general, ~90% wash their hands with soap and water and ~70% wash fruits and vegetables with water before eating. In addition, >50% ate foods outside of home and ~24% was asymptomatic and did not have a specific meal schedule. Conclusions: Among rural children, Helicobacter pylori antibody was detected in 36% of the participants, unaffected by gender, and presenting specific dietary patterns.“
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