Examinando por Autor "Nieto Inca, Roxana Maribel"

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    Efecto analgésico del extracto etanólico de las hojas de Annona muricata (guanábana) en ratones albinos
    (Universidad Privada Norbert Wiener, 2021-03-18) Nieto Inca, Roxana Maribel; Torres Veliz, Ernesto Raúl
    The research was conducted on the species Annona muricata ("guanábana"), cultivated in the Ancash department. The Objective of this study was to determine the analgesic effect of the ethanolic extract from the leaves of Annona muricata "guanábana" in albino mice. Method: The Hot Plate method was employed, using 25 male Mus musculus Balb C53 strain albino mice randomly distributed into five groups of five mice each: Group I (0.9% saline solution), Group II (diclofenac 10 mg/kg body weight), Group III (tramadol 10 mg/kg body weight), and Groups IV and V (ethanolic extracts at doses of 400 and 600 mg/kg) administered via orogastric gavage. The baseline latency time was measured before subjecting the animals to the thermal stimulus, which was evaluated every 30 minutes for 2 hours. Results: An analgesic effect was evidenced at doses of 400 and 600 mg/kg, but the greatest effect was reached with the 600 mg/kg dose at 90 minutes. An analgesic effect was also observed at 60 minutes, with both doses surpassing tramadol. Conclusion: It is concluded that the ethanolic extract from the leaves of Annona muricata "guanábana" has an analgesic effect in albino mice.