Examinando por Autor "Pérez Quispe, Marcelino"

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    Efecto gastroprotector del extracto hidroalcohólico de las flores de Spartium junceum L. ՙՙretama” en lesiones gástricas inducidas en ratas holtzman
    (Universidad Privada Norbert Wiener, 2024-10-04) De La Cruz Flores, Roy Tulio; Pérez Quispe, Marcelino; Chávez Flores, Juana Elvira
    The gastroprotective effect of the hydroalcoholic extract of the flowers of Spartium junceum L. (EHFSJ) "broom" on gastric lesions induced in Holtzman rats. Methods. The study was an applied, preclinical, quantitative, cross-sectional, explanatory, and randomized experimental study. The plant was collected from Huancavelica. Thirty-six Holtzman rats were divided into six groups: i) 0.9% physiological saline solution; ii) naproxen 550 mg/kg (N); iii) esomeprazole 30 mg/kg + N; iv) EHFSJ 250 mg/kg + N; v) EHFSJ 500 mg/kg + N; vi) EHFSJ 750 mg/kg + N. Gastric ulcers were induced with naproxen, and the Marhuenda scale was used." To assess the ulceration index, EHFSJ showed solubility in ethanol, water, and methanol. Its phytochemical profile revealed alkaloids, flavonoids, triterpenes and/or steroids, phenolic compounds, and tannins. EHFSJ 500 mg/kg showed 100% inhibition of the ulceration index. With doses of 750 mg/kg and 250 mg/kg, the inhibition was 85% and 62.7%, respectively, which was significant (p<0.05) compared to the naproxen control group. Esomeprazole 30 mg/kg inhibited the ulceration index by 89.5%. The gastroprotective effect was similar between the 500 mg/kg dose of EHFSJ and the esomeprazole group. EHFSJ does have a gastroprotective effect on gastric lesions induced in rats. Holtzman.