Examinando por Autor "Perea Moreno, Sara de Guadalupe"

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    Características clínico-epidemiológicas asociadas a condición de egreso de personas afectadas con tuberculosis multirresistente que recibieron bedaquilina durante 2016-2020 en Lima-Perú
    (Universidad Privada Norbert Wiener, 2022-04-02) Perea Moreno, Sara de Guadalupe; Benites Castillo, Santiago Moises
    The World Health Organization reports that of 10 million people who get sick with tuberculosis annually, almost half a million new cases have resistance to rifampicin; of which, 78% resulting in multi-resistance, becoming a global concern. The aim of this study was to determine the association between the clinical-epidemiological characteristics and treatment outcomes of people affected by multidrug-resistant tuberculosis. This was a retrospective cohort study in people affected by multidrug-resistant tuberculosis who received a treatment regimen that included bedaquiline between the years 2016 and 2020 in Lima, Peru and the potential factors associated with treatment otucomes were evaluated. Two hundred and fifty-five patients were included in the study. Eighty nine percent had successful treatment outcome. Age over 40 years, male gender, body mass index less than 18.5 and HIV coinfection were found to be independent factors associated with unsuccesful outcome. In this cohort, that included risk population (prior TB, previous use of second-line drugs, high drug resistance, people in prison, comorbidities), a high rate of favorable otucomes was obtained (89%), which highlights the importance of incorporating bedaquiline in treatment regimens. Age, male gender, body mass index and HIV were independent associated factors for unfavorable treament outcomes.