Examinando por Autor "Quispe Llactahuamán, Pilar Alicia"

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    Evaluación de toxicidad aguda del extracto etanólico del tubérculo Euphorbia huanchahana Klotzch & Garcke Boissier “huachangana” en ratas Holtzman
    (Universidad Privada Norbert Wiener, 2020-01-22) Quispe Llactahuamán, Pilar Alicia; Villafuerte Pedraza, Graciela; Ñañez del Pino, Daniel
    Poisoning from medicinal plants can occur due to the improper use of an apparently harmless natural substance, or as a result of absorbing an excessive amount of a phytosanitary product in a short period. The objective was to determine the acute hepatic and renal toxicity of the ethanolic extract of Euphorbia huanchahana Klotzch & Garcke Boissier, 'Huachangana,' in Holtzman rats. Methodology: An experimental study was designed, and a qualitative phytochemical profile analysis was conducted to determine the presence of primary and secondary metabolites. For the acute toxicity test, a dose of 2000 mg/kg (LD50) was administered orally in a single dose to 32 rats. Four rats were administered only distilled water. The animals remained under observation for 14 days, during which no signs of toxicity, alteration of the growth curve, or death were detected. On day 15, euthanasia was performed, and organs were removed for histopathological analysis of the liver and kidney tissues. A liver profile analysis was also conducted. Conclusion: The ethanolic extract of the Euphorbia huanchahana tuber at a dose of 2000 mg/kg showed no evidence of acute hepatic or renal toxicity in Holtzman rats.