Examinando por Autor "Rodriguez Natividad, Mariela Elizabeth"

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    Caracterización de interacciones medicamentosas en pacientes hospitalizados con patologías cardiovasculares del "Hospital Nacional Guillermo Almenara Irigoyen – EsSalud", periodo julio–noviembre 2017
    (Universidad Privada Norbert Wiener, 2018-08-20) Rodriguez Natividad, Mariela Elizabeth; Tuano Condori, Doris Janeth; Moreno Exebio, Luis Enrique
    This study was conducted with the purpose of characterizing drug–drug interactions (DDIs) in hospitalized patients with cardiovascular diseases at the Hospital Nacional Guillermo Almenara Irigoyen – EsSalud between July and November 2017. Data were collected by reviewing medical prescriptions from the clinical records of 139 hospitalized patients with these pathologies. A descriptive, prospective, and longitudinal study design was applied. After applying the selection criteria, 127 patients (91%) were found to present drug–drug interactions. Of these, 101 (73%) were male and 38 (27%) were female; 93 patients (67%) were older than 60 years. Regarding the number of prescribed drugs, 25 patients (18%) were taking six medications. Antiplatelet agents (acetylsalicylic acid and clopidogrel) accounted for 192 prescriptions (39.2%). According to the type of interaction, 48 (20%) were pharmacokinetic and 197 (80%) pharmacodynamic; the most frequent association was clopidogrel–enoxaparin, with 39 cases (15.9%). Potential interactions were identified in 245 cases (98.8%) and actual interactions in 3 cases (1.2%). With respect to the time of occurrence, 71 interactions (29%) were classified as late, while in terms of severity, 166 (68%) were considered severe. The search for drug–drug interactions was performed using the Micromedex, Drug Interaction Checker, and Medscape databases. In conclusion, 67% of the study population were aged 60 years or older and did present drug–drug interactions, the majority of whom were male. Most interactions (81%, n=147) were pharmacodynamic, and among the cardiovascular pathologies, heart failure accounted for 31.4% (n=77) of the cases.