Examinando por Autor "Sánchez Barrera, Mirtha Nancy"

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    Actividad laxante del extracto hidroalcohólico del fruto Hylocereus undatus (Haw.) Briton & Rose "pitahaya roja" en ratones albinos de la especie Mus musculus
    (Universidad Privada Norbert Wiener, 2018-05-14) Berrospi Cristobal, Rosy Katherin; Sánchez Barrera, Mirtha Nancy; Félix Véliz, Luis Miguel Visitación
    Today, constipation is a very common problem that can occur at any age. In response, the World Health Organization (WHO) has estimated that more than 80% of the population uses traditional medicine. The sample was collected in the town of Esperanza Alta (La Virgen) in the Huaral district and taxonomically classified at the Natural History Museum of the National University of San Marcos (UNMSM). The purpose of this research was to evaluate the laxative activity of the hydroalcoholic extract from the fruit of Hylocereus undatus (Haw) Britton & Rose, 'red pitahaya,' in albino mice (Mus musculus) using the intestinal transit method. The research was experimental, explanatory, analytical, and prospective. A total of 50 albino mice were used, randomly distributed into seven groups of six animals each. The extracts were administered orally at concentrations of 100, 200, 300, 400, and 600 mg/kg. The positive control group received Bisacodyl (0.25 mg/kg), and the negative control received distilled water. Thirty minutes later, all groups were administered 5% activated charcoal at a dose of 0.1 mL/10 g of body weight. After another 30 minutes, the animals were sacrificed with ether, and a laparotomy-type dissection was performed to measure the distance the charcoal traveled through the small intestine. In conclusion, the laxative activity of the hydroalcoholic extract was confirmed, with an intestinal transit of 74.13% observed at a 400 mg/kg dose. The following phytoconstituents were identified: reducing sugars, saponins, flavonoids, phenolic compounds, alkaloids, fatty compounds, and quinones.