Examinando por Autor "Sánchez Porras, Katheryne"

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    Efecto antiinflamatorio y analgésico del extracto hidroalcohólico de las hojas de Rumex cuneifolius Campd. “Romaza” mediante el método de edema subplantar y contorsiones abdominales en ratones albinos (Mus musculus)
    (Universidad Privada Norbert Wiener, 2019-03-08) Sánchez Porras, Katheryne; Zavala Villanueva, Hellen Katerine; Ñañez del Pino, Daniel
    In this study, the anti-inflammatory and analgesic effects of the hydroalcoholic extract from the leaves of Rumex cuneifolius Campd., known as "Romaza," were evaluated using the subplantar edema and abdominal writhing methods in albino mice (Mus musculus). Materials and Methods: A hydroalcoholic extract was obtained by maceration with 70% ethanol. The anti-inflammatory effect was assessed using the 1% albumin-induced subplantar edema method. The mice were divided into a Control Group, a diclofenac group (50 mg/kg), a dexamethasone group (4 mg/kg), and a hydroalcoholic extract group at doses of 50, 100, and 150 mg/kg. The analgesic effect was evaluated using the 0.8% glacial acetic acid-induced abdominal writhing model. The mice were divided into a Control Group, a paracetamol group (300 mg/kg), a tramadol group (40 mg/kg), and a hydroalcoholic extract group at doses of 50, 100, and 200 mg/kg. Results and Conclusion: The extract showed solubility in both ethanol and methanol. The qualitative phytochemical analysis revealed the presence of primary metabolites (carbohydrates and amino acids) and secondary metabolites (phenolic compounds, flavonoids, steroids and/or triterpenes, sesquiterpene lactones, quinones, and alkaloids). The study determined that the ideal dose for the anti-inflammatory effect was 100 mg/kg, with an effectiveness of 94%. The analgesic effect was confirmed at a dose of 100 mg/kg, showing a 75% effectiveness. In conclusion, the hydroalcoholic extract from the leaves of Rumex cuneifolius Campd. "Romaza" demonstrates both anti-inflammatory and analgesic effects.