Examinando por Autor "Sah, Ranjit"

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Detection of Monkeypox Virus according to The Collection Site of Samples from Confirmed Cases: A Systematic Review
(MDPI, 2022-12-22) León-Figueroa, Darwin A.; Barboza, Joshuan J.; Saldaña-Cumpa, Hortencia M.; Moreno-Ramos, Emilly; Bonilla-Aldana, D. Katterine; Valladares-Garrido, Mario J.; Sah, Ranjit; Rodriguez-Morales, Alfonso J.
Due to the rapid evolution of the monkeypox virus, the means by which the monkeypox virus is spread is subject to change. Therefore, the present study aims to analyze the detection of the monkeypox virus according to the collection site of samples from confirmed monkeypox cases. A systematic literature review was performed using PubMed, Scopus, Web of Science, and Embase databases until 5 October 2022. A total of 1022 articles were retrieved using the search strategy. After removing duplicates (n = 566) and examining by title, abstract, and full text, 65 studies reporting monkeypox case reports were included with a detailed description of risk factors, sexually transmitted infections (STIs), site of monkeypox virus-positive specimens, location of skin lesions, and diagnostic test. A total of 4537 confirmed monkeypox cases have been reported, of which 98.72% of the cases were male with a mean age of 36 years, 95.72% had a sexual behavior of being men who have sex with men, and 28.1% had human immunodeficiency virus (HIV). The most frequent locations of lesions in patients diagnosed with monkeypox were: 42.85% on the genitalia and 37.1% in the perianal region. All confirmed monkeypox cases were diagnosed by reverse transcriptase polymerase chain reaction (RT-PCR), and the most frequent locations of samples collected for diagnosis that tested positive for monkeypox virus were: 91.85% from skin lesions, 20.81% from the oropharynx, 3.19% from blood, and 2.43% from seminal fluid. The disease course of the cases with monkeypox was asynchronous, with no severe complications, and most patients did not report specific treatment but simply followed a symptomatic treatment.
Acceso abierto
Detection of Monkeypox Virus according to The Collection Site of Samples from Confirmed Cases: A Systematic Review
(MDPI, 2022-12-22) León-Figueroa, Darwin A.; Barboza, Joshuan J.; Saldaña-Cumpa, Hortencia M.; Moreno-Ramos, Emilly; Bonilla-Aldana, D. Katterine; Valladares-Garrido, Mario J.; Sah, Ranjit; Rodriguez-Morales, Alfonso J.
Due to the rapid evolution of the monkeypox virus, the means by which the monkeypox virus is spread is subject to change. Therefore, the present study aims to analyze the detection of the monkeypox virus according to the collection site of samples from confirmed monkeypox cases. A systematic literature review was performed using PubMed, Scopus, Web of Science, and Embase databases until 5 October 2022. A total of 1022 articles were retrieved using the search strategy. After removing duplicates (n = 566) and examining by title, abstract, and full text, 65 studies reporting monkeypox case reports were included with a detailed description of risk factors, sexually transmitted infections (STIs), site of monkeypox virus-positive specimens, location of skin lesions, and diagnostic test. A total of 4537 confirmed monkeypox cases have been reported, of which 98.72% of the cases were male with a mean age of 36 years, 95.72% had a sexual behavior of being men who have sex with men, and 28.1% had human immunodeficiency virus (HIV). The most frequent locations of lesions in patients diagnosed with monkeypox were: 42.85% on the genitalia and 37.1% in the perianal region. All confirmed monkeypox cases were diagnosed by reverse transcriptase polymerase chain reaction (RT-PCR), and the most frequent locations of samples collected for diagnosis that tested positive for monkeypox virus were: 91.85% from skin lesions, 20.81% from the oropharynx, 3.19% from blood, and 2.43% from seminal fluid. The disease course of the cases with monkeypox was asynchronous, with no severe complications, and most patients did not report specific treatment but simply followed a symptomatic treatment.
Acceso abierto
Epidemiologic Situation of HIV and Monkeypox Coinfection: A Systematic Review
(MDPI, 2023-11-22) Ortiz-Saavedra, Brando; Montes-Madariaga, Elizbet S.; Cabanillas-Ramirez, Cielo; Alva, Niza; Ricardo-Martínez, Alex; León-Figueroa, Darwin A.; Barboza, Joshuan J.; Mohanty, Aroop; Kumar Padhi, Bijaya; Sah, Ranjit
The most recent monkeypox (Mpox) outbreak is mostly affecting men who have sex with men (MSM) who participate in high-risk sexual behaviors, which is typically the case among human immunodeficiency virus (HIV) carriers, according to clinical and epidemiological statistics. The objective of this research is to determine the epidemiological situation of HIV and smallpox co-infection. Until 1 October 2022, a thorough evaluation of the literature was conducted utilizing the databases PubMed, Embase, Scopus, and Web of Science. Studies were evaluated based on the criteria for selection. Fifty-three studies met the selection criteria. A total of 6345 confirmed cases of monkeypox were recorded, and 40.32% (n = 2558) of these cases also had HIV co-infection. In addition, 51.36% (n = 3259) of the men (91.44%; n = 5802), whose ages ranged from 18 to 71 years, exhibited MSM-specific sexual behaviors. Co-infection with these two viruses can be especially dangerous because it can exacerbate the symptoms of both diseases and make them more difficult to treat. People with HIV are more vulnerable to certain infections, including monkeypox, because their immune systems are weakened. Therefore, it is important that they take measures to prevent infection, such as avoiding contact with infected animals, risky behaviors, and maintaining good hygiene.
Acceso abierto
“Virus Identification for Monkeypox in Human Seminal Fluid Samples: A Systematic Review“
(MDPI, 2023-03-14) Barboza, Joshuan J.; León-Figueroa, Darwin A.; Saldaña-Cumpa, Hortencia M.; Valladares-Garrido, Mario J.; Moreno-Ramos, Emilly; Sah, Ranjit; Bonilla-Aldana, D. Katterine; Rodriguez-Morales, Alfonso J.
Public health officials around the world are extremely concerned about the global outbreak of monkeypox (MPX), which has been claimed to have originated in Africa. As a result, studies into the origins and reasons behind the outbreak’s rapid spread have been sped up. The goal of the current investigation is to determine whether the monkeypox virus (MPXV) is present in seminal fluid samples from MPX cases that have been verified. Up until 6 January 2023, PubMed, Scopus, Web of Science, Embase, and ScienceDirect databases were used to conduct a thorough evaluation of the literature. The search technique returned a total of 308 items. Fourteen studies reporting the presence of MPXV in the seminal fluid of MPX-confirmed cases were included after the duplicates (n = 158) and searches by title, abstract, and full text were eliminated. In 84 out of the 643 confirmed MPX cases (13.06% or n = 643), MPXV was discovered in seminal fluid. Reverse transcriptase polymerase chain reaction (RT-PCR) was used to identify MPXV, and samples taken from skin lesions (96.27%), pharynx or oropharynx (30.48%), and blood all had higher positivity rates than other samples (12.44%). Additionally, 99.85% of respondents were male with a mean age of 36, 98.45% engaged in MSM (men who have sex with men) sexual conduct, and human immunodeficiency virus (HIV) accounted for 56.9% of all STD cases. This study offers proof that MPXV can be found in the seminal fluid of MPX sufferers. Our data imply that MPXV transmission is a possibility in these samples and that MSM are more vulnerable to it. The creation of hygienic standards is essential for the early identification of MPX cases.
Acceso abierto
“Virus Identification for Monkeypox in Human Seminal Fluid Samples: A Systematic Review“
(MDPI, 2023-03-14) Barboza, Joshuan J.; León-Figueroa, Darwin A.; Saldaña-Cumpa, Hortencia M.; Valladares-Garrido, Mario J.; Moreno-Ramos, Emilly; Sah, Ranjit; Bonilla-Aldana, D. Katterine; Rodriguez-Morales, Alfonso J.
Public health officials around the world are extremely concerned about the global outbreak of monkeypox (MPX), which has been claimed to have originated in Africa. As a result, studies into the origins and reasons behind the outbreak’s rapid spread have been sped up. The goal of the current investigation is to determine whether the monkeypox virus (MPXV) is present in seminal fluid samples from MPX cases that have been verified. Up until 6 January 2023, PubMed, Scopus, Web of Science, Embase, and ScienceDirect databases were used to conduct a thorough evaluation of the literature. The search technique returned a total of 308 items. Fourteen studies reporting the presence of MPXV in the seminal fluid of MPX-confirmed cases were included after the duplicates (n = 158) and searches by title, abstract, and full text were eliminated. In 84 out of the 643 confirmed MPX cases (13.06% or n = 643), MPXV was discovered in seminal fluid. Reverse transcriptase polymerase chain reaction (RT-PCR) was used to identify MPXV, and samples taken from skin lesions (96.27%), pharynx or oropharynx (30.48%), and blood all had higher positivity rates than other samples (12.44%). Additionally, 99.85% of respondents were male with a mean age of 36, 98.45% engaged in MSM (men who have sex with men) sexual conduct, and human immunodeficiency virus (HIV) accounted for 56.9% of all STD cases. This study offers proof that MPXV can be found in the seminal fluid of MPX sufferers. Our data imply that MPXV transmission is a possibility in these samples and that MSM are more vulnerable to it. The creation of hygienic standards is essential for the early identification of MPX cases.
Acceso abierto
Zero by 2030 and OneHealth: The multidisciplinary challenges of rabies control and elimination
(Elsevier Inc., 2022-11-21) Bonilla-Aldana, D. Katterine; Ruiz-Saenz, Julian; Martinez-Gutierrez, Marlen; Villamil-Gomez, Wilmer; Mantilla-Meluk, Hugo; Arrieta, German; León-Figueroa, Darwin A.; Benites-Zapata, Vicente; Barboza, Joshuan J.; Muñoz-Del-Carpio-Toia, Agueda; Franco, Oscar H.; Cabrera, Maritza; Sah, Ranjit; Jaffar A. Al-Tawfiq; Memish, Ziad A.; Amer, Fatma A.; Suárez, José Antonio; Henao-Martinez, Andres F.; Franco-Paredes, Carlos; Zumla, Alimuddin; Rodriguez-Morales, Alfonso J.
“Rabies, caused by a negative strand RNA-virus belonging to the genus Lyssavirus (family Rhabdoviridae of the order Mononegavirales), remains of global concern [1]. This vaccine-preventable viral zoonotic disease is present in more than 150 countries and territories [2]. Ac- cording to the World Health Organization (WHO), rabies is estimated to cause ~59,000 human deaths annually, with 95% of cases occurring in Africa and Asia [3,4]. However, rabies still occurs in other regions, such as Latin America and the Caribbean [5–8], Central Asia and the Middle East [9,10]. Whilst a number of animals can host the rabies virus, dogs are the main source of human rabies deaths, contributing up to 99% of all rabies transmissions to humans. Dog-mediated rabies has been eliminated from Western Europe, Canada, the United States of America (USA), Japan and some Latin American countries [11]. Nevertheless, the risk of reintroduction and disease among travellers to risk areas is a matter of concern [12–15]. As occurred with many other communicable and non-communicable diseases, the 2020–2022 COVID-19 pandemic negatively impacted the efforts of control and reemergence of rabies in certain countries [7,16,17]. Post-pandemic challenges to enhance con- trol and prevention are multiple and need urgent actions to achieve the goal in eight years by 2030 [16].“
Acceso abierto
Zero by 2030 and OneHealth: The multidisciplinary challenges of rabies control and elimination
(Elsevier Inc., 2022-11-21) Bonilla-Aldana, D. Katterine; Ruiz-Saenz, Julian; Martinez-Gutierrez, Marlen; Villamil-Gomez, Wilmer; Mantilla-Meluk, Hugo; Arrieta, German; León-Figueroa, Darwin A.; Benites-Zapata, Vicente; Barboza, Joshuan J.; Muñoz-Del-Carpio-Toia, Agueda; Franco, Oscar H.; Cabrera, Maritza; Sah, Ranjit; Al-Tawfiq, Jaffar A.; Memish, Ziad A.; Amer, Fatma A.; Suárez, José Antonio; Henao-Martinez, Andres F.; Franco-Paredes, Carlos; Zumla, Alimuddin; Rodriguez-Morales, Alfonso J.
“Rabies, caused by a negative strand RNA-virus belonging to the genus Lyssavirus (family Rhabdoviridae of the order Mononegavirales), remains of global concern [1]. This vaccine-preventable viral zoonotic disease is present in more than 150 countries and territories [2]. Ac- cording to the World Health Organization (WHO), rabies is estimated to cause ~59,000 human deaths annually, with 95% of cases occurring in Africa and Asia [3,4]. However, rabies still occurs in other regions, such as Latin America and the Caribbean [5–8], Central Asia and the Middle East [9,10]. Whilst a number of animals can host the rabies virus, dogs are the main source of human rabies deaths, contributing up to 99% of all rabies transmissions to humans. Dog-mediated rabies has been eliminated from Western Europe, Canada, the United States of America (USA), Japan and some Latin American countries [11]. Nevertheless, the risk of reintroduction and disease among travellers to risk areas is a matter of concern [12–15]. As occurred with many other communicable and non-communicable diseases, the 2020–2022 COVID-19 pandemic negatively impacted the efforts of control and reemergence of rabies in certain countries [7,16,17]. Post-pandemic challenges to enhance con- trol and prevention are multiple and need urgent actions to achieve the goal in eight years by 2030 [16].“