Examinando por Autor "Valverde Ortega, Fátima Lucia"

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    Efecto cicatrizante del gel elaborado a base del extracto etanólico del tubérculo Solanum tuberosum L. "tocosh" en ratas Holtzman
    (Universidad Privada Norbert Wiener, 2024-02-23) Castillo Carpio, Ruth Marlen; Valverde Ortega, Fátima Lucia; Chávez Flores, Juana Elvira
    The objective of this study was to verify the healing effect of a gel made from the ethanolic extract of the tuber Solanum tuberosum L. “tocosh” in Holtzman rats. Methodology: The analytical method was used, with a quantitative approach. The type of research was applied, and the design was experimental. The biological sample consisted of Holtzman rats, and the plant species used was the tuber Solanum tuberosum L. “tocosh.” A 70° ethanolic extract was prepared, followed by solubility testing and preliminary qualitative analysis. A gel was then formulated at concentrations of 0.5%, 1%, and 2%, and its healing response was evaluated using the second-intention incision technique and a data collection sheet. Results: The extract was soluble in water, ethanol, and methanol. The metabolites identified included phenolic compounds, alkaloids, triterpenes and/or steroids, reducing sugars, and free amino groups. The formulated gel showed good organoleptic properties and physical stability. The healing response at the 2% concentration demonstrated homogeneous healing with increased dermal thickness through cellular layers, the appearance of keratohyalin granules with extensive dermoepidermal junction, and the formation of connective tissue and collagen fibers. Conclusion: The gel made from the ethanolic extract of the tuber Solanum tuberosum L. “tocosh” at a 2% concentration showed a healing effect.