Examinando por Autor "Vega Leon, Claudio Kolbe"

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    Monitorización de los parámetros bioquímicos de las enzimas TGO, TGP y creatinina en pacientes pediátricos con leucemia linfoblástica aguda que reciben tratamiento de metrotexato año 2017
    (Universidad Privada Norbert Wiener, 2020-11-03) Sandoval Chujutalli, Sara; Vega Leon, Claudio Kolbe; Parreño Tipián, Juan Manuel
    The monitoring of glutamic oxaloacetic transaminase (AST), glutamic pyruvic transaminase (ALT), and creatinine was performed in 30 children with Acute Lymphoblastic Leukemia (ALL) receiving methotrexate treatment at a National Pediatric Institute in 2017. The study was non-experimental quantitative, retrospective, and longitudinal, utilizing optimized UV methods in the laboratory. The objective was to determine the behavior of the serum levels of the hepatic enzymes AST, ALT, and Creatinine in children, as well as the assessment of methotrexate levels at 0, 24, and 48 hours post-infusion. Results: There was a significant increase in ALT and creatinine levels from zero to 48 hours post-infusion. The percentage of elevated values was lowest in children under 6 years old and highest in the older children. The sample was split into two exact halves regarding gender. Conclusion: The enzymatic tests AST, ALT, and creatinine were found to be elevated in children with ALL treated with methotrexate, compared to the normal values. This is attributed to the existing tumor lysis syndrome and the release of intracellular elements.