Examinando por Autor "Zeña-Ñañez, Sandra"

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    Clinical-epidemiologic variation in patients treated in the first and second wave of COVID-19 in Lambayeque, Peru: A cluster analysis
    (Elsevier Ltd, 2022-07-18) Valladares-Garrido, Mario J.; Failoc-Rojas, Virgilio E.; Soto-Becerra, Percy; Zeña-Ñañez, Sandra; Torres-Roman, J. Smith; Fernández-Mogollón, Jorge L.; Colchado-Palacios, Irina G.; Apolaya-Segura, Carlos E.; Dávila-Gonzales, Jhoni A.; Arce-Villalobos, Laura R.; Neciosup-Puican, Roxana del Pilar; Calvay-Requejo, Alexander G.; Maguiña, Jorge L.; Apolaya-Segura, Moisés; Díaz-Vélez, Cristian
    “Objectives: To identify differences in the clinical and epidemiologic characteristics of patients during the first and second waves of the COVID-19 pandemic at the EsSalud Lambayeque health care network, Peru. Methods: An analytical cross-sectional study of 53,912 patients enrolled during the first and second waves of COVID-19 was conducted. Cluster analysis based on clustering large applications (CLARA) was applied to clinical-epidemiologic data presented at the time of care. The two pandemic waves were compared using clinical-epidemiologic data from epidemiologic surveillance. Results: Cluster analysis identified four COVID-19 groups with a characteristic pattern. Cluster 1 included the largest number of participants in both waves, and the participants were predominantly female. Cluster 2 included patients with gastrointestinal, respiratory, and systemic symptoms. Cluster 3 was the “severe” cluster, characterized by older adults and patients with dyspnea or comorbidities (cardiovascular, diabetes, obesity). Cluster 4 included asymptomatic, pregnant, and less severe patients. We found differences in all clinical-epidemiologic characteristics according to the cluster to which they belonged. Conclusion: Using cluster analysis, we identified characteristic patterns in each group. Respiratory, gastrointestinal, dyspnea, anosmia, and ageusia symptoms were higher in the second COVID-19 wave than the first COVID-19 wave“
  • Miniatura
    PublicaciónAcceso abierto
    Clinical-epidemiologic variation in patients treated in the first and second wave of COVID-19 in Lambayeque, Peru: A cluster analysis
    (Elsevier Ltd, 2022-07-18) Valladares-Garrido, Mario J.; Failoc-Rojas, Virgilio E.; Soto-Becerra, Percy; Zeña-Ñañez, Sandra; Torres-Roman, J. Smith; Fernández-Mogollón, Jorge L.; Colchado-Palacios, Irina G.; Apolaya-Segura, Carlos E.; Dávila-Gonzales, Jhoni A.; Arce-Villalobos, Laura R.; Neciosup-Puican, Roxana del Pilar; Calvay-Requejo, Alexander G.; Maguiña, Jorge L.; Apolaya-Segura, Moisés; Díaz-Vélez, Cristian
    “Objectives: To identify differences in the clinical and epidemiologic characteristics of patients during the first and second waves of the COVID-19 pandemic at the EsSalud Lambayeque health care network, Peru. Methods: An analytical cross-sectional study of 53,912 patients enrolled during the first and second waves of COVID-19 was conducted. Cluster analysis based on clustering large applications (CLARA) was applied to clinical-epidemiologic data presented at the time of care. The two pandemic waves were compared using clinical-epidemiologic data from epidemiologic surveillance. Results: Cluster analysis identified four COVID-19 groups with a characteristic pattern. Cluster 1 included the largest number of participants in both waves, and the participants were predominantly female. Cluster 2 included patients with gastrointestinal, respiratory, and systemic symptoms. Cluster 3 was the “severe” cluster, characterized by older adults and patients with dyspnea or comorbidities (cardiovascular, diabetes, obesity). Cluster 4 included asymptomatic, pregnant, and less severe patients. We found differences in all clinical-epidemiologic characteristics according to the cluster to which they belonged. Conclusion: Using cluster analysis, we identified characteristic patterns in each group. Respiratory, gastrointestinal, dyspnea, anosmia, and ageusia symptoms were higher in the second COVID-19 wave than the first COVID-19 wave“
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    COVID-19 Vaccine Effectiveness at a Referral Hospital in Northern Peru: A Retrospective Cohort Study
    (MDPI, 2022-05-20) Valladares-Garrido, v; Zeña-Ñañez, Sandra; Peralta, C Ichiro; Puicón-Suárez, Jacqueline B; Díaz-Vélez, Cristian; Failoc-Rojas, Virgilio E
    COVID-19 vaccines have achieved a significant reduction in mortality, yet objective estimates are needed in specific settings. We aimed to determine the effectiveness of COVID-19 vaccination at a referral hospital in Lambayeque, Peru. We conducted a retrospective cohort study from February to September 2021. We included hospitalized patients with COVID-19, whose data were stored in NotiWeb, a patient data system of the Peruvian Ministry of Health. We applied a propensity score-weighting method according to baseline characteristics of patients, and estimated hazard ratios (HR) using Cox regression models. Of 1553 participants, the average age was 55 years (SD: 16.8), 907 (58%) were male, and 592 (38%) deceased at 28-day follow-up. Before hospital admission, 74 (4.8%) had been immunized with at least one vaccine dose. Effectiveness against death in vaccinated patients was 50% at 90-day follow-up (weighted HR 0.50, 95% CI 0.28-0.89). Our results support the effectiveness of COVID-19 vaccination against death and provide information after early immunization in Peru.
  • Miniatura
    PublicaciónAcceso abierto
    COVID-19 Vaccine Effectiveness at a Referral Hospital in Northern Peru: A Retrospective Cohort Study
    (MDPI, 2022-05-20) Valladares-Garrido, v; Zeña-Ñañez, Sandra; Peralta, C Ichiro; Puicón-Suárez, Jacqueline B; Díaz-Vélez, Cristian; Failoc-Rojas, Virgilio E
    COVID-19 vaccines have achieved a significant reduction in mortality, yet objective estimates are needed in specific settings. We aimed to determine the effectiveness of COVID-19 vaccination at a referral hospital in Lambayeque, Peru. We conducted a retrospective cohort study from February to September 2021. We included hospitalized patients with COVID-19, whose data were stored in NotiWeb, a patient data system of the Peruvian Ministry of Health. We applied a propensity score-weighting method according to baseline characteristics of patients, and estimated hazard ratios (HR) using Cox regression models. Of 1553 participants, the average age was 55 years (SD: 16.8), 907 (58%) were male, and 592 (38%) deceased at 28-day follow-up. Before hospital admission, 74 (4.8%) had been immunized with at least one vaccine dose. Effectiveness against death in vaccinated patients was 50% at 90-day follow-up (weighted HR 0.50, 95% CI 0.28-0.89). Our results support the effectiveness of COVID-19 vaccination against death and provide information after early immunization in Peru.
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    Factores asociados a crisis convulsiva febril en niños peruanos
    (Editorial Ciencias Medicas, 2022-07-22) Pantoja-Costa, Ivan M.; Quiñones-Tafur, Tracy Y.; Sosa-Flores, Jorge L.; Peralta,C. Ichiro; Zeña-Ñañez, Sandra; Valladares-Garrido, Mario J.
    “Introducción: La convulsión febril es el trastorno neurológico más frecuente en la infancia y el más común en la práctica neurológica pediátrica. Tiene una etiología multifactorial. En el Perú existen estudios aislados que reportan similares factores de riesgo. Objetivo: Determinar los factores asociados a convulsiones febriles en niños atendidos en el Hospital Regional Lambayeque, Perú. Métodos: Se realizó un estudio de casos y controles en pacientes de 6 meses a 5 años en el servicio de consulta externa de Neuropediatría y emergencias, del 2015 al 2018 del Hospital Regional de Lambayeque. La muestra se constituyó por 32 casos y 32 controles emparejados 1:1 por sexo y edad. Se utilizó un cuestionario para recolectar información general, clasificación de las convulsiones febriles y posibles factores de riesgo. Se estimaron odds ratio crudos (ORc) y ajustados (ORa) mediante modelos de regresión logística simple y múltiple, respectivamente. Resultados: La mayoría de los pacientes que presentaron episodios de convulsión febril tuvieron 13-24 meses de edad (46,9 %). Se evidenció una menor probabilidad de convulsión febril en aquellos pacientes con comorbilidades congénitas (ORa: 0,17; IC 95 %: 0,03-0,93). Los pacientes que tenían diarrea aguda infecciosa (ORa: 8,16; IC 95 %: 1,37-48,55) e infección respiratoria aguda alta (ORa: 12,49; IC 95 %: 1,89-82,42) tenían una mayor probabilidad de convulsión febril. Conclusiones: Padecer de diarrea aguda infecciosa e infecciones respiratorias agudas altas aumentan la probabilidad de desarrollar convulsión febril. Por el contrario, tener una comorbilidad congénita reduce la probabilidad de esta condición.“
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    Prevalence and Factors Associated with Anxiety and Depression in Peruvian Medical Students
    (MDPI, 2022-02-07) Piscoya-Tenorio, Jorge L.; Heredia-Rioja, Walter V.; Morocho-Alburqueque, Noelia; Zeña-Ñañez, Sandra; Hernández-Yépez, Palmer J.; Díaz-Vélez, Cristian; Failoc-Rojas, Virgilo E.; Valladares-Garrido, Mario J.
    “: During medical training, students are exposed to stressors that deteriorate mental health. This study determined depression and anxiety prevalence and their associated factors in students from four medical schools in northern Peru. A cross-sectional study was conducted among medical students from Lambayeque, Peru. The Goldberg Anxiety and Zung Depression tests were applied. The dependent variables were depression and anxiety, and their association with covariates (age, sex, type of university, socioeconomic level, experience, family problem, and physical activity) was evaluated. Prevalence ratios were calculated using generalized linear models. Of 482 students, the prevalence of anxiety was 61.8% and depression was 22.0%. A severe level of anxiety was observed in 6.2% in the group between 16 and 20 years old. It was observed that private university students had higher frequencies of having depression (PR = 2.01) and anxiety (PR = 1.35); males had a lower risk of anxiety (PR = 0.82), but higher risk of depression compared to females (PR = 1.45). Performing physical activity decreased the prevalence of depression (PR = 0.53); however, it increased the frequency of anxiety (PR = 1.26). Having family problems increased the prevalence of anxiety (PR = 1.26). Medical students from private universities experienced higher rates of depression and anxiety. Depression and anxiety were associated with gender and physical activity. These findings highlight the importance of mental health promotion due to its link with quality of life and academic performance.“