Examinando por Autor "Zegarra Cárdenas, Diana"

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Acceso abierto
Formulación de fármaco por nueva vía de administración: Closantel Sódico, gel antiparasitario de uso veterinario contra Fasciola hepática
(Universidad Privada Norbert Wiener, 2015) Zegarra Cárdenas, Diana; Rivas Altez, Walter
The study was carried out with the purpose of formulating a medicine through a new route of administration of sodium closantel gel for veterinary use against Fasciola hepatica during the months of January to April 2015. An experimental, analytical, cross-sectional research work was conducted to elaborate a gel that meets the optimal conditions for use as an antiparasitic, taking into account the ideal physicochemical processes for the formulation of the gel in question. It should be noted that the physicochemical processes are important in the elaboration of the gel, with the fundamental basis being the interaction of the appropriate excipients, the active ingredient, adequate quantity, etc. Several excipients were considered for the preparation of the gel, finding that the use of Cremophor in different amounts is not suitable for the gel formulation. The use of Tween 80, which is employed for viscosity, is also not suitable for the gel formulation as it presented non-ideal characteristics. Poligel was used for the formulation of the gel, and incompatibilities and inconsistencies were found (Not suitable). Formula 1012 was used, in which it was observed that the use of 80 g is adequate for the gel formulation (Suitable). A formula with codification 1012 was also used, where the ideal temperature for the formulation of the gel is 70°C. The use of Polyethylene glycol in an amount of 200 mL is adequate for the formulation of the gel. In the search for alcohols for the gel formulation it was found that: the use of rectified ethanol alcohol in an amount of 100 mL is suitable, alcohol coded (1013) in an amount of 100 mL is suitable, alcohol coded (1014) in an adequate amount of 200 mL, and formula coded (1015) in an amount of 15 mL is suitable. The use of Monoethanolamine in an amount of 8.5 mL is optimal for the gel formulation. It should also be noted that the active ingredient sodium closantel does not present any inconvenience in the formulation of the gel.