Examinando por Materia "Ácido Tranexámico"

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  • Miniatura
    ÍtemAcceso abierto
    Effectiveness of tranexamic acid administration in reducing mortality in patients with hemorrhagic trauma.
    (Universidad Privada Norbert Wiener, 2018-07-07) Baldeón Arias, Milagros Irma; Monterrey Roque, Sandra Liliana; Perez Siguas, Rosa Eva
    Systematic observational and retrospective review of the articles reviewed, which were subjected to critical selection, using the GRADE evaluation system to identify the level of evidence. These were found in the following databases: PubMed, ScienceDirect, Scielo, Elsevier, and Epistemonikos. Of the 10 articles systematically reviewed, 20% (n=2/10) were systematic reviews, 40% (n=4/10) were randomized controlled trials, and the remaining 40% (n=4/10) were cohort studies. According to the results obtained from the systematic review conducted in this study, the articles come from the countries of England (80%) and the United States (10%). Results: Of all the articles reviewed, 90% (n=9/10) report that the administration of tranexamic acid is effective in reducing mortality in patients with hemorrhagic trauma. 10% (n=1/10) report that the administration of tranexamic acid is not effective in reducing mortality in patients with hemorrhagic trauma. Conclusion: Based on the ten articles reviewed, it is concluded that the administration of tranexamic acid is effective in reducing mortality in patients with hemorrhagic trauma.
  • Miniatura
    ÍtemAcceso abierto
    Effectiveness of tranexamic acid administration in reducing mortality in patients with hemorrhagic trauma.
    (Universidad Privada Norbert Wiener, 2018-07-07) Monterrey Roque, Sandra Liliana; Perez Siguas, Rosa Eva
    Systematic observational and retrospective review of the articles reviewed, which were subjected to critical selection, using the GRADE evaluation system to identify the level of evidence. These were found in the following databases: PubMed, ScienceDirect, Scielo, Elsevier, and Epistemonikos. Of the 10 articles systematically reviewed, 20% (n=2/10) were systematic reviews, 40% (n=4/10) were randomized controlled trials, and the remaining 40% (n=4/10) were cohort studies. According to the results obtained from the systematic review conducted in this study, the articles come from the countries of England (80%) and the United States (10%). Results: Of all the articles reviewed, 90% (n=9/10) report that the administration of tranexamic acid is effective in reducing mortality in patients with hemorrhagic trauma. 10% (n=1/10) report that the administration of tranexamic acid is not effective in reducing mortality in patients with hemorrhagic trauma. Conclusion: Based on the ten articles reviewed, it is concluded that the administration of tranexamic acid is effective in reducing mortality in patients with hemorrhagic trauma.
  • Miniatura
    ÍtemAcceso abierto
    Effectiveness of tranexamic acid use in cardiac surgery with extracorporeal circulation to reduce blood transfusion needs
    (Universidad Privada Norbert Wiener, 2018-11-24) Vidal Alvarez, Sonia; Contreras Bustos, Mirtha; Glenni Garay, Zarely Zabeli
    Objective: Systematize the evidence on the effectiveness of the use of tranexamic acid in cardiac surgery with extracorporeal circulation to reduce the need for blood transfusions. Materials and methods: systematic review that synthesizes the results of multiple investigations, identifying the most relevant. The PICO method was used to structure the research question, the CASPE templates were applied to the articles for validation and relevance, and a summary table of quality of evidence and strength of recommendation was prepared by applying the GRADE templates. Results: in the final selection, 10 articles were chosen, finding that 60% correspond to Europe (Spain, Belgium, France and Germany), 20% America (Canada and Cuba), 10% Asia (India) and 10% Africa ( Ethiopia). Most of them are experimental studies (60%), systematic reviews (20%) and cohorts (20%). 80% of reviews had high and 20% moderate quality of evidence, 100% had strong recommendation strength. 80% were performed on adult patients and 20% on pediatric patients. 100% concluded that the use of tranexamic acid reduces blood loss. Conclusion: From the reviewed articles it is evident that the use of tranexamic acid is effective in reducing blood loss, which contributes to the reduction of blood transfusions.