Examinando por Materia "Ácidos Grasos Insaturados"

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Critical review: effects of Omega 3 polyunsaturated fatty acid supplementation in patients with hematologic cancer
(Universidad Privada Norbert Wiener, 2022-11-08) Pascual Dextre, Hugo Gerardo; Bohórquez Medina, Andrea Lisbet
Studies suggest that supplementing Omega 3 to patients with Hematological Neoplasms can reduce the side effects of antineoplastic treatment. Secondary research is presented, which is a critical review and is titled: Effects of Omega 3 Polyunsaturated Fatty Acid Supplementation in Patients with Hematological Cancer, its purpose was to investigate the role of omega 3 in patients with hematological malignancies. The clinical question was: Will supplementation with Omega 3 polyunsaturated fatty acids present effects in patients with hematological cancer who are undergoing antineoplastic treatment? The model used (NuBE) Evidence-Based Nutrition. The information was searched in the search engines SCIELO, SCOPUS, SCIENCE DIRECT, PUBMED, MEDLINE, finding 33 articles, and selecting 11 that have been evaluated with the CASPE tool, selecting the Randomized Clinical Trial, entitled “ω-3 fatty acids as adjuvant therapy improve hepatotoxicity induced by Methotrexate in children and adolescents with acute lymphoblastic leukemia: A randomized controlled study with placebo“, which has a level of evidence AII and Strong Grade of Recommendation. The critical comment admitted that there is a beneficial effect when supplementing with Omega 3 to patients with hematological cancer who are undergoing antineoplastic treatment.
Acceso abierto
Critical Review: Effects of Omega-3 Polyunsaturated Fatty Acid Supplementation on Vascular Access Patency of Patients with Chronic Kidney Disease in Renal Replacement Therapy
(Universidad Privada Norbert Wiener, 2021-01-14) Palacios Melgarejo, Katerine Alexandra; Gutíerrez Ramírez, Karla Verónica
Nutritional intervention is supplementation with fatty acids in patients with chronic kidney disease in renal replacement therapy. The present secondary research entitled as a critical review: Effects of supplementation with omega 3 polyunsaturated fatty acids on the permeability of vascular accesses of patients with chronic kidney disease on renal replacement therapy, aimed to identify the effects of supplementation with fatty acids polyunsaturated omega 3 in the permeability of vascular accesses of patients with chronic kidney disease in renal replacement therapy The clinical question was: - Will the nutritional intervention of supplementation with omega 3 fatty acids improve the Permeability of vascular access in patients with chronic kidney disease on renal replacement therapy? The Evidence-Based Nutrition (NuBE) methodology was used. The information search was carried out in Medline, Pubmed and Scielo, finding 17 articles, being selected 9 that have been evaluated by the CASPE critical reading tool, finally selecting the review and meta-analysis article entitled Omega – 3 polyunsaturated fatty acid supplementation to prevent arteriovenous fistula and graft failure: a systematic review and meta-analysis of randomized controlled trials, which has a level of evidence I and Grade of Recommendation I, according to the expertise of the researcher. The critical commentary led to the conclusion that omega-3 PUFA supplementation initiated at the time of arteriovenous access surgery likely prevents loss of primary patency within 12 months.
Acceso abierto
Revisión crítica: efecto de la suplementación de ácidos grasos poliinsaturados omega 3 en el nivel de alfa treonina quinasa (AKT1) en pacientes pediátricos oncológicos con quimioterapia
(Universidad Privada Norbert Wiener, 2025-07-17) Santamaria Arce, Williams Manuel; Bohórquez Medina, Andrea Lisbet
La enzima alfa treonina quinasa (AKT1), tiene un papel crucial en el cáncer al regular la sobrevivencia, incremento y crecimiento de las células neoplásicas, promoviendo su desarrollo y renuencia a la apoptosis. Los ácidos grasos omega-3 desempeñan una parte trascendente al graduar los niveles de AKT1 en el contexto neoplásico, se ha demostrado que tienen la capacidad de regular a la baja los niveles de AKT1 en células cancerosas. Esto sugiere que los omega-3 podría ser beneficioso como terapia de apoyo en el tratamiento del cáncer, al suprimir la actividad de AKT1 y, por lo tanto, inhibir el crecimiento y progresión tumoral. El presente trabajo tenía como propósito hacer el análisis crítico profesional conforme con las investigaciones clínicas sobre el omega 3 y los niveles de AKT1. La búsqueda se realizó en PUBMED, SCIENCE DIRECT, Redalyc, hallando 24, de los cuales 12 fueron evaluados con CASPE. Finalmente, se seleccionó el Ensayo Clínico Aleatorizado: “Omega-3 supplementation to reduce alpha threonine kinase (AKT1) levels in children with acute lymphoblastic leukemia (ALL) in the induction phase of chemotherapy”, al cual se le otorgó el nivel más alto de evidencia luego de la lectura crítica. La valoración final nos permite concluir que es seguro suplementar con ácidos grasos poliinsaturados Omega 3 en pacientes pediátricos que reciben quimioterapia.