Examinando por Materia "Alcaloides"

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Acceso abierto
Actividad analgésica y antiinflamatoria del extracto hidroalcohólico de las hojas de Passiflora edulis Sims "maracuyá"
(Universidad Privada Norbert Wiener, 2019-03-06) Jalixto Alata, Sonia Carola; Salas Gutierrez, Cristina Angélica; Chávez Flores, Juana Elvira
The species Passiflora edulis Sims, or "maracuyá," is a plant that grows in northern Peru, specifically in the Lima Department, Barranca Province, Supe district, in the Venado Muerto Ravine. This study aimed to evaluate the analgesic and anti-inflammatory activity of the hydroalcoholic extract from the leaves of Passiflora edulis Sims. Methodology: A total of 56 Holtzmann strain rats of different sexes were used for the evaluation of inflammation. The rats were divided into 8 groups of seven animals. Inflammation was induced using the 0.1 mL albumin-induced plantar edema method, and the plantar volume was measured with a plethysmometer every hour for 6 hours. For the analgesic activity evaluation, the 0.8% acetic acid-induced abdominal writhing method was employed. A total of 49 Mus musculus strain mice of different sexes were divided into 7 groups of seven animals. The number of abdominal writhes was individually quantified over a 20-minute period. Results and Conclusion: The results demonstrated anti-inflammatory activity, as the 800 mg/kg hydroalcoholic extract inhibited the development of plantar edema with an effect of 100% within one hour of application, comparable to 4 mg of dexamethasone. The study also showed the analgesic activity of the 400 mg/kg hydroalcoholic extract, which achieved an effect of 70%.
Acceso abierto
Actividad cicatrizante del extracto hidroalcohólico de las hojas de Ruellia graecizans Backer (paque-paque) en ratones albinos Mus Musculus CEPA BALB/C53
(Universidad Privada Norbert Wiener, 2020-08-13) Heredia Luis, Nuria Lissbeth; Chávez Flores, Juana Elvira
The objective of this research was to confirm the wound-healing activity of the hydroalcoholic extract from the leaves of Ruellia graecizans Backer, 'paque-paque,' in Balb/C53 strain albino mice (Mus musculus). Methodology: The plant was collected in El Rollo, Cutervo, Cajamarca, at an altitude of 1900 m.a.s.l. Solubility tests and a qualitative analysis were performed on the hydroalcoholic extract. A total of 70 mice with an average body weight of 30-40 g were distributed into seven groups. To determine wound-healing activity, gels with the extract at various concentrations (1%, 2%, 5%, and 10%) were prepared and applied to induced lesions using the method described by Vaisberg et al. (1989). These gels were compared to a standard gel and a control base gel. The results showed that the 10% gel had a healing efficacy of over 80%, comparable to the standard gel. Conclusion: The wound-healing activity of the 10% gel based on the topical application of the Ruellia graecizans Backer 'paque-paque' leaf extract was confirmed.
Acceso abierto
Estudio de utilización de antimicrobianos restringidos en apendicitis aguda en el servicio de Cirugía Pediátrica del Hospital San Bartolomé durante el periodo de enero a julio de 2010
(Universidad Privada Norbert Wiener, 2013) Juárez Moreyra, Enrique; Salazar Tuanama, Rita Haydee
Acute appendicitis is the inflammation of the cecal or vermiform appendix, which begins with obstruction of the appendiceal lumen, resulting in increased intraluminal pressure due to mucus accumulation associated with the low elasticity of the serosa. Clinically, it is divided into complicated appendicitis: perforated, gangrenous appendix, or periapendicular abscess with subsequent compromise of adjacent structures; and uncomplicated appendicitis: absence of perforation, gangrene, or periapendicular abscess. The prophylactic use of antimicrobials directly reduces hospital stay by providing adequate protection to the patient with a single dose of medication, avoiding the prolonged intrahospital stay implied by extended treatment regimens, and also reduces the incidence of infectious complications, resulting in shorter hospitalization. In antimicrobial treatment, cephalosporins (18.8%), aminoglycosides (27.2%), nitroimidazoles (30.4%), lincosamides (15.2%), amphenicols (7.9%), and penicillins (0.5%) were used. The most commonly used antimicrobial was metronidazole (costing 91.76 nuevos soles), representing 30.4% of the total antimicrobials. The most frequently used restricted antimicrobials were metronidazole 500 mg (ampoule), cefotaxime 500 mg (ampoule), and ceftazidime 1 g (ampoule). An evaluation was made of the different antimicrobials in terms of cost and quantities. Analytical monitoring of leukocyte levels was carried out to determine inflammation and diagnose the patient with acute appendicitis. Out of a total of 77 pediatric patients treated for acute appendicitis at the San Bartolomé Hospital from January to June 2010, distributed by sex (41 male patients and 36 female), it was found that the most affected age group was 6 to 10 years, representing 46% of cases.