Examinando por Materia "Alcaloides"

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Acceso abierto
Actividad analgésica y antiinflamatoria del extracto hidroalcohólico de las hojas de Passiflora edulis Sims "maracuyá"
(Universidad Privada Norbert Wiener, 2019-03-06) Jalixto Alata, Sonia Carola; Salas Gutierrez, Cristina Angélica; Chávez Flores, Juana Elvira
The species Passiflora edulis Sims, or "maracuyá," is a plant that grows in northern Peru, specifically in the Lima Department, Barranca Province, Supe district, in the Venado Muerto Ravine. This study aimed to evaluate the analgesic and anti-inflammatory activity of the hydroalcoholic extract from the leaves of Passiflora edulis Sims. Methodology: A total of 56 Holtzmann strain rats of different sexes were used for the evaluation of inflammation. The rats were divided into 8 groups of seven animals. Inflammation was induced using the 0.1 mL albumin-induced plantar edema method, and the plantar volume was measured with a plethysmometer every hour for 6 hours. For the analgesic activity evaluation, the 0.8% acetic acid-induced abdominal writhing method was employed. A total of 49 Mus musculus strain mice of different sexes were divided into 7 groups of seven animals. The number of abdominal writhes was individually quantified over a 20-minute period. Results and Conclusion: The results demonstrated anti-inflammatory activity, as the 800 mg/kg hydroalcoholic extract inhibited the development of plantar edema with an effect of 100% within one hour of application, comparable to 4 mg of dexamethasone. The study also showed the analgesic activity of the 400 mg/kg hydroalcoholic extract, which achieved an effect of 70%.
Acceso abierto
Actividad cicatrizante del extracto hidroalcohólico de las hojas de Ruellia graecizans Backer (paque-paque) en ratones albinos Mus Musculus CEPA BALB/C53
(Universidad Privada Norbert Wiener, 2020-08-13) Heredia Luis, Nuria Lissbeth; Chávez Flores, Juana Elvira
El objetivo de esta investigación fue: Comprobar la Actividad cicatrizante del extracto hidroalcohólico de las hojas de Ruellia graecizans Backer “paque-paque” en ratones albinos Mus musculus cepa Balb/C53. Metodología: La especie vegetal fue colectada en el centro poblado el Rollo, distrito de Choros, provincia de Cutervo, departamento de Cajamarca, con una altitud de 1900 m.s.n.m. Con el extracto hidroalcohólico de las hojas “paque-paque”, se realizó pruebas de solubilidad y análisis cualitativo. Se utilizaron 70 ratones, con un peso corporal promedio de 30 -40 g de ambos sexos (cepa Balb/C53/CNPB), los cuales fueron distribuidos en siete grupos. Para determinar la actividad cicatrizante, se preparó geles a base del extracto hidroalcohólico de las hojas “paque-paque” en distintas concentraciones (1, 2, 5 y 10%), que fueron aplicados a los ratones, utilizando el método descrito por Vaisberg y Col. (1989), en lesiones inducidas; estos geles fueron comparados con el grupo estándar (extracto líquido de cebolla 10 g, heparina sódica 0.04 g (5000 U.I), alantoína 1 g, excipientes c.s.p 100 g. ) gel ®, y el grupo control gel Base, se obtuvo de resultado, que el extracto hidroalcohólico de las hojas “paque-paque” tiene actividad cicatrizante con el gel al 10% con una eficacia de cicatrización superior al 80%, siendo comparable con el (extracto líquido de cebolla 10 g, heparina sódica 0.04 g (5000 U.I), alantoína 1 g, excipientes c.s.p 100 g. ) gel®. En conclusión, se comprobó la actividad cicatrizante del gel al 10% a base del extracto de hojas Ruellia graecizans Backer “paque-paque” por vía tópica.
Acceso abierto
Estudio de utilización de antimicrobianos restringidos en apendicitis aguda en el servicio de Cirugía Pediátrica del Hospital San Bartolomé durante el periodo de enero a julio de 2010
(Universidad Privada Norbert Wiener, 2013) Juárez Moreyra, Enrique; Salazar Tuanama, Rita Haydee
Acute appendicitis is the inflammation of the cecal or vermiform appendix, which begins with obstruction of the appendiceal lumen, resulting in increased intraluminal pressure due to mucus accumulation associated with the low elasticity of the serosa. Clinically, it is divided into complicated appendicitis: perforated, gangrenous appendix, or periapendicular abscess with subsequent compromise of adjacent structures; and uncomplicated appendicitis: absence of perforation, gangrene, or periapendicular abscess. The prophylactic use of antimicrobials directly reduces hospital stay by providing adequate protection to the patient with a single dose of medication, avoiding the prolonged intrahospital stay implied by extended treatment regimens, and also reduces the incidence of infectious complications, resulting in shorter hospitalization. In antimicrobial treatment, cephalosporins (18.8%), aminoglycosides (27.2%), nitroimidazoles (30.4%), lincosamides (15.2%), amphenicols (7.9%), and penicillins (0.5%) were used. The most commonly used antimicrobial was metronidazole (costing 91.76 nuevos soles), representing 30.4% of the total antimicrobials. The most frequently used restricted antimicrobials were metronidazole 500 mg (ampoule), cefotaxime 500 mg (ampoule), and ceftazidime 1 g (ampoule). An evaluation was made of the different antimicrobials in terms of cost and quantities. Analytical monitoring of leukocyte levels was carried out to determine inflammation and diagnose the patient with acute appendicitis. Out of a total of 77 pediatric patients treated for acute appendicitis at the San Bartolomé Hospital from January to June 2010, distributed by sex (41 male patients and 36 female), it was found that the most affected age group was 6 to 10 years, representing 46% of cases.