Examinando por Materia "Anti-Inflammatory Agents"

Mostrando 1 - 19 de 19

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Actividad analgésica y antiinflamatoria del extracto etanólico de las flores de Bidens andicola H.B.K. "quiquo"
(Universidad Privada Norbert Wiener, 2018-03-01) Huarcaya Huarcaya, Liliana; Sotelo Saravia, Nancy Avelina; Chávez Flores, Juana Elvira
The objective of this study was to determine the analgesic and anti-inflammatory activities of the ethanolic extract of Bidens andicola H.B.K “quiquo” flowers. For the analgesic activity, the modified Koster et al. model was employed, and the study groups were: negative control (distilled water), positive control (0.8% glacial acetic acid), ethanolic extract of Bidens andicola H.B.K. “quiquo” flowers at 50, 100, and 200 mg/kg, paracetamol 300 mg/kg, and tramadol 40 mg/kg. For the anti-inflammatory activity, the plantar edema method with 1% albumin was used, and the groups were: negative control (distilled water), ibuprofen 400 mg/kg, dexamethasone 1 mg/kg, and the ethanolic extract at 200, 400, and 600 mg/kg. The results show that the ethanolic extract of Bidens andicola H.B.K. “quiquo” flowers at 100 mg/kg (65%) and 200 mg/kg (70%) exhibits analgesic activity, lower than tramadol (91%) but comparable to paracetamol (81%). Regarding the anti-inflammatory activity, the ethanolic extract at 200, 400, and 600 mg/kg demonstrated efficacy, with the 600 mg/kg dose showing the greatest anti-inflammatory effect (100%), similar to dexamethasone and ibuprofen. It was confirmed that the ethanolic extract of Bidens andicola H.B.K. “quiquo” flowers possesses both analgesic and anti-inflammatory activities.
Acceso abierto
Actividad analgésica y antiinflamatoria del extracto hidroalcohólico de las hojas de Passiflora edulis Sims "maracuyá"
(Universidad Privada Norbert Wiener, 2019-03-06) Jalixto Alata, Sonia Carola; Salas Gutierrez, Cristina Angélica; Chávez Flores, Juana Elvira
The species Passiflora edulis Sims, or "maracuyá," is a plant that grows in northern Peru, specifically in the Lima Department, Barranca Province, Supe district, in the Venado Muerto Ravine. This study aimed to evaluate the analgesic and anti-inflammatory activity of the hydroalcoholic extract from the leaves of Passiflora edulis Sims. Methodology: A total of 56 Holtzmann strain rats of different sexes were used for the evaluation of inflammation. The rats were divided into 8 groups of seven animals. Inflammation was induced using the 0.1 mL albumin-induced plantar edema method, and the plantar volume was measured with a plethysmometer every hour for 6 hours. For the analgesic activity evaluation, the 0.8% acetic acid-induced abdominal writhing method was employed. A total of 49 Mus musculus strain mice of different sexes were divided into 7 groups of seven animals. The number of abdominal writhes was individually quantified over a 20-minute period. Results and Conclusion: The results demonstrated anti-inflammatory activity, as the 800 mg/kg hydroalcoholic extract inhibited the development of plantar edema with an effect of 100% within one hour of application, comparable to 4 mg of dexamethasone. The study also showed the analgesic activity of the 400 mg/kg hydroalcoholic extract, which achieved an effect of 70%.
Acceso abierto
Actividad analgésica y antiinflamatoria del extracto hidroalcólico de hojas y tallos de Leucheria daucifolia (D. Don.) Crisci "Churoq wasin" en ratones
(Universidad Privada Norbert Wiener, 2018-12-07) Soto Requez, Yvon Carla; Ruiz Rondinel, Sandra; Chávez Flores, Juana Elvira
The present study aimed to evaluate the analgesic and anti-inflammatory activity of the hydroalcoholic extract of leaves and stems of Leucheria daucifolia (D. Don.) Crisci “Churoq wasin”. For the analgesic activity, the model of abdominal writhing induced by 0.8% acetic acid was employed; 49 mice were used, and the evaluated groups were: negative control (distilled water), positive control (0.8% acetic acid), hydroalcoholic extract at 50, 100 and 200 mg/kg, compared with paracetamol 300 mg/kg and tramadol 40 mg/kg. For the anti-inflammatory effect, the auricular edema method was used with an irritant agent (6% xylene diluted in acetone) applied to the mouse auricle. A total of 49 albino mice were used, and the study groups were: vaseline cream, creams prepared with the hydroalcoholic extract at 0.5, 1 and 2%, compared with diclofenac 1% cream and hydrocortisone 1% cream. The results show that the hydroalcoholic extract of leaves and stems of Leucheria daucifolia (D. Don.) Crisci “Churoq wasin” at a dose of 100 mg/kg presents analgesic activity with an inhibition percentage of writhing of 62%, not surpassing tramadol (86%) but comparable to paracetamol (76%). Regarding anti-inflammatory activity, the cream with 2% extract presented an inhibition percentage of inflammation of 48.7%, which is comparable to hydrocortisone 1% and diclofenac 1%. It was confirmed that the hydroalcoholic extract possesses both analgesic and anti-inflammatory activity in mice.
Acceso abierto
Actividad antiinflamatoria de un ungüento formulado a partir del extracto hidroetanólico de las hojas de Cissus gongylodes Burch. ex Baker “Suelda Suelda” en ratas albinas
(Universidad Privada Norbert Wiener, 2024-10-14) Esteban Paucar, Steffany Wengyi; Romero Mendoza, Winnie Ashley; Dueñas Zurita, Julia
El objetivo fue determinar la actividad antiinflamatoria del ungüento formulado a partir del extracto hidroetanólico de las hojas de Cissus gongylodes Burch ex Baker “Suelda Suelda” (UEHCG) en ratas albinas. Métodos. El estudio tuvo diseño experimental, tipo aplicado, corte longitudinal, enfoque cuantitativo, alcance explicativo, muestreo aleatorio simple, la planta fue recolectada en distrito Mazamani, provincia Satipo, departamento Junín, se empleó 30 ratas albinas cepa Holtzman, se formó 5 grupos y administró tratamientos vía tópico, grupo 1: ungüento base, grupo 2: diclofenaco gel 1%, grupo 3: UEHCG 1%, grupo 4: UEHCG 3%, grupo 5: UEHCG 5%, la inflamación fue inducida con carragenina 1% en NaCl 0,1 mL en aponeurosis plantar de la rata, el edema fue medido con Vernier a las 0, 1, 3, 6 y 8 horas, al extracto se realizó prueba de solubilidad y perfil fitoquímico cualitativo. Resultados. El extracto fue soluble en metanol, agua y etanol, se identificó compuestos fenólicos, flavonoides, taninos, alcaloides y leucoantocianidinas. El UEHCG 5% mostró efecto antiinflamatorio significante (p<0,05) a las 6 y 8 horas con inhibición de la inflamación de 48% y 74% respectivamente, el diclofenaco 1% inhibió la inflamación en 45% a las 8 horas y fue significante (p<0,05) comparado con el grupo control. Conclusión. El UEHCG 5% si tiene actividad antiinflamatoria significante a las 6 y 8 horas de tratamiento en ratas albinas con 74% de inhibición de la inflamación.
Acceso abierto
Actividad antiinflamatoria del extracto etanólico de las hojas del Baccharis buxifolia (Lam.) Pers. “Talla” en ratones
(Universidad Privada Norbert Wiener, 2018-08-22) Rivera Vicuña, David Walter; Chávez Flores, Juana Elvira
The present research aimed to evaluate the anti-inflammatory activity of the ethanolic extract of Baccharis buxifolia (Lam.) Pers. “Talla” leaves in mice. Solubility testing and a qualitative phytochemical profile of the ethanolic extract were carried out. To determine anti-inflammatory activity, the subplantar edema method with 1% albumin, as described by Winter et al. (modified), was employed. Forty-two albino mice (Mus musculus strain Balb/C53) of both sexes, each weighing more than 25 g, were used. The mice were randomly distributed into six groups and subsequently administered 0.1 mL of 1% albumin in the subplantar region. The plant extract was tested at concentrations of 100, 200, and 400 mg/kg of body weight, while dexamethasone (4 mg/kg) and diclofenac (50 mg/kg) were used as standard drugs. The results showed that the ethanolic extract of Baccharis buxifolia leaves, at 400 mg/kg, exhibited the greatest anti-inflammatory effect at two hours, with an inhibition percentage of 62%, compared with the lower extract concentrations (100 mg/kg: 10%; 200 mg/kg: 28%) and with the standard drugs diclofenac (50 mg/kg: 31%) and dexamethasone (4 mg/kg: 48%). It is concluded that the ethanolic extract of Baccharis buxifolia (Lam.) Pers. “Talla” leaves demonstrates significant anti-inflammatory activity at a dose of 400 mg/kg.
Acceso abierto
Actividad antioxidante y antiinflamatoria del extracto etanólico de las hojas de Passiflora tripartita var. mollissima (Kunth) "tumbo serrano"
(Universidad Privada Norbert Wiener, 2019-03-08) Ramos Huamaní, Hilda; Pari Colque, Regina; Chávez Flores, Juana Elvira
The plant species Passiflora tripartita var. mollissima (Kunth), commonly known as “tumbo serrano,” is native to Peru and grows in the regions of Cuzco, Lambayeque, Lima, Pasco, Piura, and Talara. The objective of this study was to determine the antioxidant and anti-inflammatory activity of the ethanolic extract of Passiflora tripartita var. mollissima leaves. The ethanolic extract was obtained by maceration, after which solubility testing and phytochemical screening were conducted to identify secondary metabolites. Antioxidant activity was evaluated using the DPPH method, while anti-inflammatory activity was assessed through the paw edema test induced by a phlogistic agent (1% albumin). The results demonstrated antioxidant activity at the following concentrations: 125 µg/mL (79.55%), 93.75 µg/mL (60.99%), 62.5 µg/mL (41.93%), and 31.25 µg/mL (21.82%). Compared with the TROLOX standard, the extract also showed significant anti-inflammatory activity, with a dose of 600 mg/kg producing an effect from the first hour of administration (p = 0.000), which was comparable to that of dexamethasone at 4 mg. In conclusion, the ethanolic extract of Passiflora tripartita var. mollissima leaves exhibits both antioxidant and anti-inflammatory activity.
Acceso abierto
Efecto antiinflamatorio del extracto hidroalcohólico de las hojas de Luma Chequen (Molina) A. Gray “Arrayán” mediante el método de edema subplantar en ratas
(Universidad Privada Norbert Wiener, 2019-12-02) Linares Martínez, Dámaris Rosana; Chávez Flores, Juana Elvira
The objective of this research was to confirm the anti-inflammatory effect of the hydroalcoholic extract from the leaves of Luma chequen (Molina) A. Gray, 'arrayán,' using the subplantar edema method in rats. Materials and methods: Solubility and qualitative analyses were performed. To determine the anti-inflammatory effect, a modified subplantar edema method with a 1% albumin solution was used. 48 albino rats (Holtzman strain), with an average weight of 200-250g, were acclimated for 7 days and randomly distributed into six groups of eight. Afterward, 0.1 mL of a 1% albumin solution was applied to the subplantar area. The hydroalcoholic extract was used at doses of 200, 400, and 600 mg/kg of body weight, and dexamethasone (4 mg/kg) and diclofenac (50 mg/kg) were used as standard drugs. Results: The hydroalcoholic extract showed solubility in distilled water, ethanol, and methanol. The qualitative analysis confirmed the presence of flavonoids, phenols, tannins, alkaloids, coumarins, and steroids and/or triterpenoids. In the anti-inflammatory effect evaluation, the extract at a dose of 200 mg/kg showed an inflammatory inhibition of 82.3% at the sixth hour, which was greater than diclofenac's 77.1% and comparable to dexamethasone's 90.1%. Conclusions: The anti-inflammatory effect of the hydroalcoholic extract from the leaves of Luma chequen (Molina) A. Gray, 'arrayán,' was confirmed. At a dose of 200 mg/kg, its effect was greater than diclofenac's and comparable to dexamethasone.
Acceso abierto
Efecto antiinflamatorio y analgésico del extracto etanólico de la cáscara Inga feuillei DC. "pacay" en ratones
(Universidad Privada Norbert Wiener, 2022-02-18) Vásquez Quispe, Ángel David; Villacorta Antón, Santos Enrique; Chávez Flores, Juana Elvira
In Peru, there are various medicinal plants with therapeutic benefits; the plant species Inga feuillei comes from northern Peru (La Libertad - Trujillo). Objective: This study aims to demonstrate the anti-inflammatory and analgesic effect of the ethanolic extract from the peel of Inga feuillei DC, 'pacay,' in mice. Methods: To evaluate the anti-inflammatory effect, 42 rats were divided into 7 groups of 6, and the subplantar edema method described by Winter was used. To evaluate the analgesic effect, 42 mice were divided into 7 groups of 6, and the Koster et al. method was used. Results: The ethanolic extract from the 'pacay' peel showed its greatest analgesic effect at a concentration of 300 mg/kg (87.7%), surpassing the standards of Paracetamol 500 mg/kg (42.8%) and tramadol (86.4%). The greatest anti-inflammatory effect was at a concentration of 500 mg/kg (42.8%), an effect comparable to the standards of Ibuprofen 400 mg/kg and Dexamethasone 4mg/kg. Conclusion: The analgesic and anti-inflammatory effects of the ethanolic extract from the peel of Inga feuillei DC were demonstrated in mice.
Acceso abierto
Efecto antiinflamatorio y analgésico del extracto hidroalcohólico de las hojas de Malva arborea L. Webb & Berthel (malva) en ratones
(Universidad Privada Norbert Wiener, 2025-06-02) Guz, Pawel; Lavanto Chiara, María del Pilar; Chávez Flores, Juana Elvira
The objective of this preclinical study was to determine the anti-inflammatory and analgesic effects of the hydroalcoholic extract of the leaves of Malva arborea L. Webb & Berthel (mallow) in mice. Methodology: To test the anti-inflammatory effect, the model of auricular edema inhibition induced with 0.6% xylene topically applied to the auricle in mice was used. Thirty-six mice were divided into 6 groups: Negative control, 1% diclofenac and hydrocortisone creams, and creams based on the hydroalcoholic extract (0.5, 1 and 2%). To test the analgesic effect, the model of abdominal contortions induced with 0.8% acetic acid in mice was used. The 6 groups of 6 mice were: Negative control, paracetamol 300 mg/kg, tramadol 50 mg/kg, and hydroalcoholic extract (100, 200 and 400 mg/kg). Finally, the percentage of atrial edema inhibition and the percentage of abdominal writhing inhibition were calculated. Results: The percentage of atrial edema inhibition was 57.6% in the 2% hydroalcoholic cream extract group, compared to the 1% diclofenac group (51.2%). The percentage of abdominal writhing inhibition was 85.8% in the 400 mg/kg hydroalcoholic extract group, compared to the 50 mg/kg tramadol group (85.6%), both administered orally. Conclusion: The hydroalcoholic extract of the leaves of Malva arborea L. Webb & Berthel has anti-inflammatory and analgesic effects.
Acceso abierto
Efecto antiinflamatorio y analgésico del extracto hidroalcohólico de las hojas de Rumex cuneifolius Campd. “Romaza” mediante el método de edema subplantar y contorsiones abdominales en ratones albinos (Mus musculus)
(Universidad Privada Norbert Wiener, 2019-03-08) Sánchez Porras, Katheryne; Zavala Villanueva, Hellen Katerine; Ñañez del Pino, Daniel
In this study, the anti-inflammatory and analgesic effects of the hydroalcoholic extract from the leaves of Rumex cuneifolius Campd., known as "Romaza," were evaluated using the subplantar edema and abdominal writhing methods in albino mice (Mus musculus). Materials and Methods: A hydroalcoholic extract was obtained by maceration with 70% ethanol. The anti-inflammatory effect was assessed using the 1% albumin-induced subplantar edema method. The mice were divided into a Control Group, a diclofenac group (50 mg/kg), a dexamethasone group (4 mg/kg), and a hydroalcoholic extract group at doses of 50, 100, and 150 mg/kg. The analgesic effect was evaluated using the 0.8% glacial acetic acid-induced abdominal writhing model. The mice were divided into a Control Group, a paracetamol group (300 mg/kg), a tramadol group (40 mg/kg), and a hydroalcoholic extract group at doses of 50, 100, and 200 mg/kg. Results and Conclusion: The extract showed solubility in both ethanol and methanol. The qualitative phytochemical analysis revealed the presence of primary metabolites (carbohydrates and amino acids) and secondary metabolites (phenolic compounds, flavonoids, steroids and/or triterpenes, sesquiterpene lactones, quinones, and alkaloids). The study determined that the ideal dose for the anti-inflammatory effect was 100 mg/kg, with an effectiveness of 94%. The analgesic effect was confirmed at a dose of 100 mg/kg, showing a 75% effectiveness. In conclusion, the hydroalcoholic extract from the leaves of Rumex cuneifolius Campd. "Romaza" demonstrates both anti-inflammatory and analgesic effects.
Acceso abierto
Efecto antiinflamatorio y capacidad antioxidante del extracto hidroalcohólico del pericarpio de Nephelium lappaceum L. "rambután"
(Universidad Privada Norbert Wiener, 2020-01-30) Salazar Barrios, Evelin Patricia; Palomino Ludeña, Mirian; Justil Guerrero, Hugo Jesús
The objective was to determine the anti-inflammatory effect and antioxidant capacity of the hydroalcoholic extract from the pericarp of Nephelium lappaceum L. 'rambutan.' Method: For the anti-inflammatory effect, the 3% carrageenan-induced plantar edema model (Winter et al. modified) was used. Seven groups of six mice were formed. After one hour, 0.1 mL of 3% carrageenan was administered, and the edema of the inflamed paw was measured at 1, 2, 3, and 4 hours. For the antioxidant capacity, the modified Lalitha and Selvam method was used. 6 mL of blood was extracted, and eight groups of three replicates each were prepared. The samples were centrifuged at 1500 rpm for 10 minutes, and the absorbance was measured at 415 nm at 50 and 90 minutes. Results: The 500 mg/kg dose showed the highest anti-inflammatory effect (22.58%) at the 4-hour mark. For antioxidant capacity, the 50 µg/mL concentration yielded the best result at 50 minutes (95.54%), while the 100 µg/mL concentration was the best at 90 minutes (77.95%). Conclusion: The anti-inflammatory effect and antioxidant capacity of the hydroalcoholic extract from the pericarp of Nephelium lappaceum L. 'rambutan' were confirmed.
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Efectos analgésico y antiinflamatorio del extracto hidroalcohólico de las hojas de Munnozia hastifolia (POEPP.) H. ROB. & Brettell "Ala de murciélago"
(Universidad Privada Norbert Wiener, 2021-05-29) Quispe Pilco, David Francisco; Condori Bobadilla, Johanna Paola; Chávez Flores, Juana Elvira
In this research, the leaves of Munnozia hastifolia (Poepp.) H. Rob. & Brettell, or "Ala de murciélago," were collected. To determine the analgesic activity, the 0.8% glacial acetic acid-induced abdominal writhing model was used. The plant extract was used at concentrations of 50, 100, and 200 mg/kg, with Paracetamol Q.P. 300 mg/kg and Tramadol 40 mg/kg as comparative standards. To determine the anti-inflammatory effect, the 1% albumin-induced plantar edema method was used. The study groups included a negative control, ibuprofen 400 mg/kg, dexamethasone 1 mg/kg, and three concentrations of the extract at doses of 200, 400, and 600 mg/kg. The treatment lasted 6 hours, with a measurement taken every hour. Results showed that the hydroalcoholic extract at doses of 50, 100, and 200 mg/kg demonstrated analgesic activity of 34.1%, 42.1%, and 76.2%, respectively. None of the doses were superior to tramadol (88.3%), but the 200 mg/kg concentration (76.2%) was comparable to paracetamol (80.38%). Regarding anti-inflammatory activity, the extract at all three doses (200, 400, and 600 mg/kg) showed an anti-inflammatory effect. The 600 mg/kg dose was the first treatment to return to its basal state (0% inflammation in 3h), followed by the 400 mg/kg dose, which took an additional hour to reach the same state (4h), a time similar to the comparative treatment dexamethasone 1mg/kg. The 200 mg/kg dose and ibuprofen 400 mg/kg still presented 3.1% and 2.8% inflammation, respectively, at the end of the treatment.
Acceso abierto
Evaluación del efecto analgésico y antiinflamatorio del extracto etanólico de las hojas de Maquira coriacea (H. Karst.) C.C. Berg "Capinuri" en ratones
(Universidad Privada Norbert Wiener, 2021-12-03) Arzapalo Campos, Julissa; Castillo Jiménez, María Bertha; Chávez Flores, Juana Elvira
The objective of this research was to evaluate the analgesic and anti-inflammatory effect of the ethanolic extract from the leaves of Maquira coriacea (H. Karst.) C.C. Berg, 'Capinuri,' in mice. Methodology: A 'Solubility Test' and 'Preliminary Qualitative Analysis' were performed to identify the secondary metabolites present in the 'Capinuri' extract. To evaluate the 'Analgesic Effect,' the 0.8% acetic acid-induced abdominal writhing method was used. The extract was evaluated at concentrations of 50, 100, and 200 mg/kg, with tramadol (40 mg/kg) and acetaminophen (300 mg/kg) as standards. For the 'Anti-inflammatory Effect,' the 0.6% xylene-induced ear edema method was employed via topical administration. Creams formulated with the 'Capinuri' extract at 0.5, 1, and 2% were compared with Diclofenac 1% cream and Hydrocortisone 1% cream. Results: The analgesic effect at a dose of 200 mg/kg showed a 33% inhibition of abdominal writhes, which was below tramadol's (42%) but above acetaminophen's (23%). Regarding the anti-inflammatory effect, the 2% cream showed a 58.6% inhibition of inflammation in the right ear pinna of the mice, which was less than hydrocortisone's (84.8%) but similar to diclofenac's (50.3%). Conclusions: The ethanolic extract from the leaves of Maquira coriacea (H. Karst.) C.C. Berg, 'Capinuri,' showed both an analgesic and an anti-inflammatory effect in mice.
Acceso abierto
Evaluación del efecto antiinflamatorio de la grasa de Boa constrictor constrictor "Boa Mantona" comercializada en el Emporio Comercial de Gamarra – La Victoria. Lima 2015
(Universidad Privada Norbert Wiener, 2018-01-29) Atequipa Quispe, Jessica; Cabrera Pachacama, Elisabeth; Chávez Flores, Juana Elvira
An experimental study was conducted to determine the anti-inflammatory effect of Boa constrictor constrictor fat (“Boa Mantona”) using the xylene-induced ear edema method in mice. The study population consisted of 48 mice, distributed into six groups of eight animals each. Topical applications included pure Boa fat, creams formulated with the fat at concentrations of 15%, 20%, and 30%, and the reference drug diclofenac 1% cream. Simultaneously, a physicochemical and analytical study of Boa constrictor constrictor fat was performed. For statistical analysis, descriptive and inferential methods were applied; data were processed to determine the mean ± standard deviation, and ANOVA was employed for inferential analysis. The results showed that the fat of Boa constrictor constrictor and the creams at 20% and 30% concentrations produced significant anti-inflammatory effects (p<0.05), indicating a differentiated anti-inflammatory response. In the analytical study, gas chromatography revealed that 97.7% of the fatty acids were identified, of which 31.9% were saturated fatty acids, 43.6% monounsaturated fatty acids, and 22.2% polyunsaturated fatty acids (omega-6 and omega-3).
Acceso abierto
Evaluación del efecto antiinflamatorio de un gel formulado a base del extracto hidroalcohólico de las hojas de Quararibea cordata (Bonpl.) Vischer "zapote" en ratones y evaluación analgésica del extracto hidroalcohólico
(Universidad Privada Norbert Wiener, 2021-02-08) Villalobos Salazar, Rocio Cristina; Neyra Remicio, Dieyse Soraya; Chávez Flores, Juana Elvira
Inflammation and pain are bodily processes that affect human health and are related to many diseases; hence, this experimental study was conducted. The objective was to evaluate the anti-inflammatory effect of a gel formulated from the hydroalcoholic extract of Quararibea cordata (Bonpl.) Vischer, "Zapote," in mice, and to evaluate the analgesic effect of the hydroalcoholic extract. Methodology: For the pharmacological study, 112 albino mice with a body weight of 30 to 40 g of both sexes were used, distributed into seven groups of eight mice. The anti-inflammatory effect was evaluated using the xylene-induced ear edema model. The experimental groups were: Blank Group, Control Group, hydroalcoholic extract gel at 0.5,1, and 2%, and dexamethasone and diclofenac at 1% in gel. The analgesic effect was evaluated using the acetic acid-induced abdominal writhing model. The experimental groups were: Blank Group, Control Group, hydroalcoholic extract at concentrations of 50,100, and 200 mg/kg, tramadol 40 mg/kg, and paracetamol 300 mg/kg, administered orally. Results: The analgesic effect was achieved at an extract concentration of 200 mg/kg with a writhing inhibition percentage of 62.5%, which did not reach tramadol's (89.3% ) but was similar to paracetamol's (45.5% ). Meanwhile, the anti-inflammatory effect of the 2% extract gel showed an inflammation inhibition percentage of 53.8%, which was similar to 1% dexamethasone and diclofenac. Conclusion: The evaluation of the hydroalcoholic extract from the leaves of Quararibea cordata (Bonpl.) Vischer, "Zapote," evidenced both an anti-inflammatory and analgesic effect in mice.
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Evaluación del efecto antiinflamatorio y analgésico del extracto etanólico de la raíz de Dracontium spruceanum (Schott) G.H. Zhu "jergón sacha" en ratones
(Universidad Privada Norbert Wiener, 2024-05-23) Ramos Tello, Luis Jhonston; Ccorahua De La Cruz, Moisés Claudio; Chávez Flores, Juana Elvira
In Peru, there is a great variety of plants with medicinal properties. This research aimed to evaluate the anti-inflammatory and analgesic effect of the ethanolic extract of the root of Dracontium spruceanum (Schott) G.H. Zhu “jergón sacha” in mice. Methodology: A “Solubility Test” and “Preliminary Qualitative Analysis” were conducted to identify secondary metabolites present in the extract. To evaluate the anti-inflammatory effect, 36 albino mice were used, divided into 6 groups (n=6). The “ear edema” method induced by Q.P. xylene was used; as positive controls, 1% diclofenac gel and 1% dexamethasone gel were applied. The Dracontium spruceanum extract was evaluated in gel form at 0.5%, 1%, and 2% concentrations. Vaseline was used as the negative control. All administrations were topical. For the analgesic effect, 36 mice were divided into 6 groups (n=6). The “tail withdrawal” method from a thermal source was used, and latency time was measured. As positive controls, tramadol hydrochloride 20 mg/kg and paracetamol 400 mg/kg were used. The extract was evaluated at doses of 200, 400, and 600 mg/kg. Physiological saline 0.1 mL/10g was used as the negative control. All administrations were oral. Results: The anti-inflammatory effect of the Dracontium spruceanum extract in gel form at 2% showed a high inflammation inhibition of 95.8%, surpassing the positive controls (dexamethasone 91.8% and diclofenac 89.3%). The 0.5% and 1% extract gels also showed inhibition (68.8% and 88.7%, respectively). Regarding the analgesic effect, the 400 mg/kg dose of the extract showed an average increase in pain reaction time of 55.2%, though it was surpassed by tramadol (76.4%). The 200 mg/kg and 600 mg/kg doses showed 31.3% and 25.9% increases, respectively, while paracetamol showed 12%. Conclusions: The ethanolic extract of the root of Dracontium spruceanum (Schott) G.H. Zhu showed a notable anti-inflammatory effect in gel form via topical administration at 2%, more than at 0.5% and 1%. A significant analgesic effect was also observed at the 400 mg/kg dose via oral administration.
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Experiencia de las personas de la tercera edad en el uso del plantago major (llantén) en el poblado de Bayóvar San Juan de Lurigancho Lima Metropolitana – 2023
(Universidad Privada Norbert Wiener, 2024-08-27) Cabello Guadalupe, Sara Nélida; Davila De La Cruz, Tania; Félix Véliz, Luis Miguel Visitación
The objective of this research work was to evaluate the experiences of elderly people in the use of Plantago major (llantén) in the town of Bayóvar San Juan de Lurigancho 2023. Method: a descriptive level study was carried out, quantitative approach, observational and cross-sectional design in a sample of 178 elderly people, to whom a questionnaire was administered through surveys. Result: 75% of the elderly people who used Plantago major (llantén) were female, the most common age being 60 to 65 years, 29% purchased the product on the market, the most recommended source mentioned was the friend 36%, in ailments and method of preparation most treated are joint pain and bumps or sprains, the plaster was used mostly (33.7 and 39.1% respectively) compared to other diseases; Likewise, for the symptom of pain, the plaster was used (45%) and for inflammation, inhalation was mostly used (47.4%). Conclusion: It was determined that, according to their experiences, 100% of the elderly people who used Plantago major (llantén) in the town of Bayóvar San Juan de Lurigancho would recommend its use because they all presented relief or improvement in their ailments and/or illnesses.
Acceso abierto
Formulación de un gel a partir del extracto etanólico de las hojas de Mangifera indica L. "mango" con efecto antiinflamatorio en ratones
(Universidad Privada Norbert Wiener, 2021-05-22) Laureano Soca, Cielo Lucero; Chacaltana Pérez, Mercedes Tathiana; Chávez Flores, Juana Elvira
Currently, the production of phytopharmaceuticals or natural products with pharmacological properties often lacks scientific study to validate their medicinal uses and ensure they are free from microorganisms harmful to public health. The objective of this study was to confirm the anti-inflammatory effect of a gel formulated from the ethanolic extract of Mangifera indica L. ('Mango') leaves. Methodology: An experimental pharmacological study was conducted to evaluate the anti-inflammatory effect of the gel using the ear edema method in mice. The mice were randomly distributed into six groups of five, with noxa induced by xylene. The anti-inflammatory effect was compared with 1% diclofenac gel. In parallel, an accelerated stability study of the test gel was performed, evaluating organoleptic characteristics, pH, and microbial limit. Results: The 2.4% gel demonstrated similar effectiveness to the 1% diclofenac gel, with inflammation inhibition of 35.46% and 32.91%, respectively. The stability study evidenced that the 1.2% gel maintained better preservation at the end of the study period. Conclusion: It was confirmed that the gel derived from the ethanolic extract of the leaves of Mangifera indica L. 'Mango' has anti-inflammatory effectiveness via topical administration.
Acceso abierto
Potencial actividad antiinflamatoria de la crema a partir de las lactonas sesquiterpénicas aisladas de las testas de Persea americana Mill "Palta Fuerte" sobre ratones albinos
(Universidad Privada Norbert Wiener, 2018-07-11) Choquelahua Paquiyauri, Yanina; Illesca Ramón, Jenny; Nué Martinez, Jorge Jonathan
This research evaluated the anti-inflammatory activity of sesquiterpene lactones isolated from the polar fraction of the chloroform extract of Persea americana Mill “Palta fuerte” seeds. For the study, creams were prepared based on the polar fraction of the chloroform extract containing sesquiterpene lactones at different concentrations (1%, 5%, 10%, 20%), reducing inflammation caused by xylene and improving vascular permeability. The results obtained from the xylene-induced inflammation model indicated that creams at 1%, 5%, 10%, and 20% based on the polar fraction of the chloroform extract prevented inflammation of the auricular pavilion (right ear) by 44.94%, 60.20%, 61.04%, and 67.56%, respectively. The anti-inflammatory drugs (Diclofenac 1% gel and Hydrocortisone 1% ointment) induced inflammation inhibition of 64.34% and 81.75%, respectively. These results demonstrate the anti-inflammatory activity of Persea americana Mill “Palta fuerte” seeds.