Examinando por Materia "Antidepresivos"

Mostrando 1 - 7 de 7

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Actividad ansiolítica y antidepresiva del aceite esencial de las semillas de Foeniculum vulgare Mill. “hinojo” en ratones albinos
(Universidad Privada Norbert Wiener, 2019-10-14) Arotinco Rojas, Karin Griselda; Delgado Cipriano, Clara María de los Angeles; Collantes Llacza, Adela Marlene
According to the World Health Organization (WHO), depression and anxiety account for 4.3% of the global burden of morbidity. The objective of this study was to determine the anxiolytic and antidepressant activity of the essential oil from the seeds of Foeniculum vulgare Mill., 'fennel,' in albino mice. Methodology: The methodology used was experimental, explanatory, quantitative, and applied. The seeds were collected in the province of Huarochirí (Matucana). The essential oil (EO) was extracted by hydrodistillation. The anxiolytic activity was evaluated using the marble burying method in 40 mice at oral doses of 2.5, 5, and 10 mL/kg of EO, compared to diazepam at 10 mg/kg. The antidepressant activity was evaluated using the forced swim test in 40 mice at oral doses of 2.5, 5, and 10 mL/kg of EO, compared to fluoxetine at 20 mg/kg. Results: The essential oil of Foeniculum vulgare showed antidepressant activity at the first two doses and anxiolytic activity at all three doses. Conclusion: The essential oil demonstrated antidepressant activity at doses of 2.5, 5, and 10 mL/kg and showed activity comparable to diazepam.
Acceso abierto
Consumo de medicamentos antidepresivos y su impacto en la salud en adolescentes atendidos en el Centro de Salud Mental Comunitario Vitaliza Parcona – Ica, 2023
(Universidad Privada Norbert Wiener, 2023-11-25) Hume Gallegos, Jacqueline Sadith; Masco Terrones, Javier Alexander; Collantes Llacza, Adela Marlene
The objective was to determine the relationship between the consumption of antidepressant medications and the impact on health in adolescents treated at the Vitaliza Parcona Community Mental Health Center – Ica, 2023. The study was basic, with a hypothetical-deductive method, quantitative approach, non-experimental design, cross-sectional type, and correlational descriptive scope. The sample consisted of 152 adolescents of both sexes, selected through non-probabilistic quota sampling. The instrument used was a questionnaire with 30 closed-ended questions.Regarding the results, 81.6% were between 14–17 years old, 55.3% were male, 48% lived only with their mother, and 11.2% with another relative. In terms of depressive symptoms, 84.9% presented a depressed state, 69.1% loss of interest in activities, 41.4% appetite alteration, 76.3% drowsiness, 77% anxiety, 70.4% lack of concentration, 73.7% fatigue, 81.6% low self-esteem, and 36.2% suicidal ideation. Concerning antidepressant use, 59.2% consumed sertraline, 43.4% fluoxetine, and 2% amitriptyline. Regarding health impacts: at the digestive level, 22.4% had intestinal cramps, 19.7% nausea and/or vomiting, 25% dry mouth, and 53.3% increased appetite; at the nervous system level, 39.5% presented dizziness, 38.9% insomnia, 19.7% increased sweating, and 41.4% headaches and nervousness; at the cognitive level, 36.2% presented confusion, 48.7% decreased concentration, 47.4% decreased learning, and 31.6% numbness.The consumption of antidepressant medications was related to health impact in adolescents, with a correlation value of 0.143. Conclusion: The consumption of antidepressant medications was related to health impact in adolescents treated at the Vitaliza Parcona Community Mental Health Center – Ica, 2023, with a very low positive correlation.
Acceso abierto
Efecto antidepresivo del extracto etanólico de las hojas de Annona cherimola Mill “chirimoya” en ratones albinos
(Universidad Privada Norbert Wiener, 2024-08-29) Mestanza Cordova, Jhon Anderson; Paez Huaynates, Heyde Norma; Ramos Jaco, Antonio Guillermo
The objective of this study was to evaluate the antidepressant effect of the ethanolic extract of Annona cherimola Mill "cherimoya" leaves in albino mice. Methodology: A solubility test and a preliminary qualitative phytochemical analysis were performed to determine the secondary metabolites. To demonstrate the antidepressant activity, the tail suspension test was used in 35 mice divided into 5 groups: control, placebo, 10 mg/kg, 20 mg/kg and 30 mg/kg of the ethanolic extract of Annona cherimola Mill (cherimoya) leaves. The plant sample was 1 kg of cherimoya leaves collected in the province of Huarochirí, Peru. Results: The ethanolic extract of Annona cherimola Mill (cherimoya) leaves was shown to be soluble in ethanol (EtOH) and methanol (MeOH), with the presence of secondary metabolites such as alkaloids, globular proteins, steroidal or triterpenoid nucleus, anthraquinones, lactones, phenols, flavonoids and other phenolic compounds. Mice treated with 20 mg/kg of extract showed a significant increase in immobility time in the tail suspension test compared to the control and placebo groups. Conclusion: The antidepressant effect of the ethanolic extract of Annona cherimola Mill “cherimoya” leaves was proven in albino mice.
Acceso abierto
Factores asociados a la prescripción de psicofármacos en adultos mayores atendidos en un hospital nacional de SMP, Lima-2025
(Universidad Privada Norbert Wiener, 2026-01-21) Ascencio Morales, Jhonatan Smith; Rendon Bautista, Gabriela; Ñañez del Pino, Daniel
The study aimed to identify the factors associated with the prescription of psychotropic drugs in older adults treated at a national hospital in San Martín de Porres, Lima, during 2025; an analytical method was used, with a quantitative approach, basic type, non-experimental design, cross sectional cut and descriptive level, including a sample of older adults and using questionnaires and observation guides as instruments; results showed a significant association between the prescription of psychotropic drugs and sociodemographic factors (age, educational level, occupation, income and marital status), biological factors (presence of chronic diseases, functional deterioration, memory problems and dependency), and psychosocial factors (symptoms of depression, discrimination, loneliness and absence of family/friend support), with SSRI antidepressants being the most prescribed drugs; it was concluded that sociodemographic, biological and psychosocial factors are significantly associated with the prescription of psychotropic drugs in older adults, highlighting the importance of comprehensive geriatric mental health care.
Acceso abierto
Frecuencia de consumo con antidepresivos en pacientes de 40 a 60 años en tiempos de COVID-19 en botica Inkafarma Lima Perú – 2022
(Universidad Privada Norbert Wiener, 2022-11-25) Rodriguez Ninahuanca, Valeria Estefhany; León Apac, Gabriel Enrique
The objective of this research is to determine the frequency of antidepressant medication consumption among patients aged 40 to 60 during COVID-19 at Inkafarma pharmacy, Lima, Peru – 2022. Method: This study follows a descriptive, quantitative, cross-sectional, and prospective design. The sample included 278 respondents aged 40 to 60 years. The survey technique was employed, and the instrument used was a questionnaire, working with a 95% confidence level. Results: The male gender accounted for 66.55% (185), while females represented 33.45% (93). The age group with the highest proportion was 46 to 50 years, representing 90.65% (252), whereas the 56 to 60 years age group had the lowest proportion at 0.36% (1). Married individuals were the most surveyed at 78.78% (219), and individuals with a university degree made up the majority of respondents at 57.55% (160). Conclusion: It is concluded that antidepressant consumption, based on gender, age group, marital status, and educational level, was low during COVID-19. Furthermore, no significant relationship was found between the frequency of antidepressant medication consumption and these variables.
Acceso abierto
Interacciones medicamentosas potenciales en prescripciones médicas de pacientes ambulatorios del servicio de psiquiatría del Hospital III de Emergencias Grau EsSalud, periodo abril–noviembre del 2017
(Universidad Privada Norbert Wiener, 2021-06-22) Escarza Aquino, Katherine Hortensia; Salas Milla, Karina; Torres Veliz, Ernesto Raúl
Our study, "Potential Drug-Drug Interactions Frequently Present in the Psychiatry Service of the Hospital III de Emergencias Grau EsSalud, April – November 2017," had the Objective of determining the Potential Drug-Drug Interactions (PDDIs) present in medical prescriptions for outpatient psychiatry patients. Methodology: The study was retrospective, descriptive, and cross-sectional. A total of 632 medical prescriptions were analyzed. Results: 1,296 potential drug interactions were found. The most frequent PDDIs were: clonazepam–sertraline (8.7%), clonazepam–fluoxetine (4.0%), and biperiden–risperidone (3.9%). By mechanism, pharmacokinetic accounted for 30% and pharmacodynamic for 70%. By degree of severity, minor severity was 4.4%, moderate severity was 87.1%, and major severity was 8.5%. The most frequently implicated drugs in the PDDIs were: clonazepam (17.6%), sertraline (13.5%), and biperiden (8.6%). The most frequent diagnoses found were: mixed anxiety and depressive disorder (25.9%), paranoid schizophrenia (14.2%), and moderate depressive episode (11.4%). Conclusion: 66% of the population presented at least one potential drug interaction, and 34% presented no type of interaction in the psychiatry service of the Hospital III de Emergencias Grau-EsSalud.
Acceso abierto
Patrones de uso de ansiolíticos y antidepresivos en pacientes atendidos en la botica Vidsalud de Ate Vitarte en el periodo de octubre 2021-abril 2022 Lima- Perú
(Universidad Privada Norbert Wiener, 2022-10-06) Flores Quispe, Norma Vicenta; Roque Gutierrez, Lucy Leandra; Collantes Llacza, Adela Marlene
Psychopathologies themselves are already a problem, the excessive use of antidepressants, anxiolytics and sedatives / hypnotics is even more serious, therefore the present work aimed to describe the patterns of use of anxiolytics and antidepressants in patients treated at the VidSalud pharmacy in the Ate Vitarte district in a sample attended during the period from October 2021 to April 2022. Method: For this, a data collection form was applied from the prescription and patient care in the pharmacy. It was found that the psychotropic drugs most used by patients are alprazolam 35.4% and clonazepam 32.6%, followed by sertraline 19.3%. The prescription doses are conservative and do not differ much between the patients surveyed. The specialty of the prescriber issuing the prescription exceeds the professional capacity to prescribe them with a full balance of their side effects and efficacy for the conditions treated. The duration of treatment with psychotropic drugs in the patients evaluated ranges from 1 week to 10 months. The class of psychotropic drugs used is equally balanced for anxiolytics and antidepressants. The psychopathologies associated with the prescription of psychotropic drugs are anxiety and depression in their clinical and subclinical forms, followed by insomnia. It is concluded that, given a scenario in which the use of psychotropic drugs for anxiety, depression, and other psychopathologies is increasing, and that given the possibility of side effects associated with the type of psychotropic drug and the duration of treatment, the abuse of prescribing outside the relevant medical specialty and patient abuse should be carefully reviewed.