Examinando por Materia "Antiulcerosos"

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Acceso abierto
Actividad antiulcerosa del extracto etanólico de las hojas de Ficus carica L. "Higo" en ratas
(Universidad Privada Norbert Wiener, 2018-09-17) Abarca Vega, Erika Victoria; Chávez Flores, Juana Elvira
Objective: To determine the antiulcer activity of the ethanolic extract of Ficus carica L. (“Fig”) leaves in rats. An ethanolic maceration of the plant leaves was carried out, followed by solubility testing, preliminary phytochemical analysis, and evaluation of antiulcer activity using the modified Lee (1971) technique at doses of 300, 600, and 800 mg/kg. A total of 60 Holtzman rats were randomly distributed into six groups, induced with gastric ulcer using naproxen 200 mg/kg, with ranitidine 30 mg/kg as the reference drug. The extract was shown to be soluble in methanol, ethanol, and distilled water. The preliminary phytochemical screening revealed the presence of flavonoids, alkaloids, phenolic compounds, and free amino groups. Regarding the antiulcer activity, the most effective treatment was the Ficus carica L. leaf extract at 800 mg/kg, achieving 83.01% inhibition of gastric ulceration, compared with ranitidine, which achieved 73.58% inhibition. These results were obtained using the Marhuenda scale. It was determined that the ethanolic extract of Ficus carica L. leaves at a dose of 800 mg/kg presents antiulcer activity in rats.
Acceso abierto
Efecto gastroprotector del extracto hidroalcohólico de las hojas de Mutisia acuminata R. & P. "Chinchilcuma"
(Universidad Privada Norbert Wiener, 2013) Borja Bartolo, Kely; Chávez Flores, Juana Elvira
The increase in the commercialization of adulterated medicines and the lack of control in the Peruvian pharmaceutical market pose risks to patients’ health. The objective of the present work is to contribute to the control and sanitary surveillance of amoxicillin in film-coated tablets. Amoxicillin was chosen as the sample because it is an essential medicine, and three aspects were evaluated: first, the origin of the medicine, using checklists based on Supreme Decrees No. 014-2011/SA and 016-2011/SA. Second, the physicochemical evaluation of medicines of dubious and reliable origin was carried out, taking as reference the monograph of Amoxicillin Tablets, the general chapters <905> and <1151> of the United States Pharmacopeia 35. Third, the behavior of amoxicillin after being subjected to accelerated partial-time stability conditions was evaluated according to Sanitary Directive No. 031-MINSA/DIGEMID, which regulates stability studies of medicines. The reliable-origin sample complied with the requirements of Supreme Decrees No. 014-2011/SA and 016-2011/SA. The dubious-origin samples (DOS) 2 and 3 complied with the requirements of Supreme Decree No. 016-2011/SA, whereas DOS1 did not; the establishments from which the dubious-origin samples were taken did not comply with the requirements of Supreme Decree No. 014-2011/SA. In the physicochemical analysis, the samples met the acceptance criteria of USP 35 and of Sanitary Directive No. 031-MINSA/DIGEMID. It is concluded that amoxicillin marketed in non-pharmaceutical and pharmaceutical establishments meets the physicochemical acceptance criteria and is stable under accelerated partial-time stability conditions; however, the non-pharmaceutical establishments did not comply with the requirements of Supreme Decrees No. 014-2011/SA and No. 016-2011/SA.
Acceso abierto
Evaluación del efecto gastroprotector del extracto etanólico de las hojas de Alternanthera lanceolata (Benth.) Schinz. “lancetilla” en ratas Holtzman
(Universidad Privada Norbert Wiener, 2022-08-25) Bruno Mingore, Corina Isabel; Chuquiyauri Rua, Roxana; Chávez Flores, Juana Elvira
Peru is a country with vast biodiversity, featuring diverse flora resources to meet human needs; medicinal plants are capable of treating and curing certain human diseases and ailments worldwide. Objective: To evaluate the gastroprotective effect of the ethanolic extract from the leaves of Alternanthera lanceolata (Benth) Schinz, 'Lancetilla,' in rats. Methodology: Albino rats were used, divided randomly into 6 groups of 8 animals each. The gastroprotective effect was determined using the Lee method with the Marhuenda scale for evaluation, and an anatomopathological section analysis was also performed. Results: The ethanolic extract from the leaves of Alternanthera lanceolata at a concentration of 600 mg/kg presented the highest gastroprotective effect, obtaining 45.19% mucosal loss, compared to the Ranitidine 300 mg/kg standard, which obtained 50.38% mucosal loss. The anatomopathological sections confirmed the gastroprotective effect by showing only a lesion grade of 1. Conclusion: The gastroprotective effect of the ethanolic extract from the leaves of Alternanthera lanceolata (Benth) Schinz, 'Lancetilla,' at a concentration of 600 mg/kg was confirmed.
Acceso abierto
Relación del uso de medicamentos antiulcerosos y procinéticos con síntomas dispépticos en población adulta de una botica de Lurín, Lima 2023
(Universidad Privada Norbert Wiener, 2024-10-28) Laura Arroyo, Norma Lourdes; Larico Sucaticona, Katia Soledad; Cárdenas Orihuela, Robert Armando
The objective was to determine the relationship between the use of antiulcer and prokinetic medications and dyspeptic symptoms in the adult population. Method. The study was nonexperimental, cross-sectional, quantitative approach, correlational descriptive level, basic type, hypothetical deductive method, sample was 196 adults, intentional sampling, a questionnaire was used for data collection, using Spearman's Rho the hypothesis was tested. Results. It was observed that adults with dyspeptic symptoms were 60% female, 55% aged 40-50 years; use of antiulcer and prokinetic medications, 40.8% consumed ranitidine, 31.1% omeprazole, 25.5% esomeprazole, 20.9% pantoprazole. 29.6% aluminum hydroxide and magnesium hydroxide, 15.8% sucralfate, 20.4% magaldrate, 40.3% bismuth, 55.6% metoclopramide, 41.8% domperidone; 54.1% relieved dyspeptic symptoms; occasionally 40.3% caused dizziness and/or sleep. In dyspeptic symptoms, 31.1% postprandial fullness was observed; 70.4% meteorism, 51% early satiety; 64.8% epigastric pain, 20.9% nausea, 20.4% vomiting, 64.8% belching, 36.2% epigastric burning; 49% burning or burning in the stomach, 65.3% acid regurgitation, 40.8% cruet; 24.5% skipped breakfast, 14.3% lunch, 26% dinner; 29.1% consumed alcoholic beverages, coffee, tobacco, and soft drinks. 33.7% consumed foods rich in condiments and fat. The p-value was 0.000 (p<0.05) and the correlation was 0.537 indicating moderate positive correlation. Conclusion. There is a moderate positive relationship between the use of antiulcer and prokinetic medications with dyspeptic symptoms in the adult population of a pharmacy in Lurín, Lima.