Examinando por Materia "Bombacaceae"

Seleccione resultados tecleando las primeras letras
Mostrando 1 - 1 de 1
  • Miniatura
    PublicaciónAcceso abierto
    Evaluación del efecto antiinflamatorio de un gel formulado a base del extracto hidroalcohólico de las hojas de Quararibea cordata (Bonpl.) Vischer "zapote" en ratones y evaluación analgésica del extracto hidroalcohólico
    (Universidad Privada Norbert Wiener, 2021-02-08) Villalobos Salazar, Rocio Cristina; Neyra Remicio, Dieyse Soraya; Chávez Flores, Juana Elvira
    Inflammation and pain are bodily processes that affect human health and are related to many diseases; hence, this experimental study was conducted. The objective was to evaluate the anti-inflammatory effect of a gel formulated from the hydroalcoholic extract of Quararibea cordata (Bonpl.) Vischer, "Zapote," in mice, and to evaluate the analgesic effect of the hydroalcoholic extract. Methodology: For the pharmacological study, 112 albino mice with a body weight of 30 to 40 g of both sexes were used, distributed into seven groups of eight mice. The anti-inflammatory effect was evaluated using the xylene-induced ear edema model. The experimental groups were: Blank Group, Control Group, hydroalcoholic extract gel at 0.5,1, and 2%, and dexamethasone and diclofenac at 1% in gel. The analgesic effect was evaluated using the acetic acid-induced abdominal writhing model. The experimental groups were: Blank Group, Control Group, hydroalcoholic extract at concentrations of 50,100, and 200 mg/kg, tramadol 40 mg/kg, and paracetamol 300 mg/kg, administered orally. Results: The analgesic effect was achieved at an extract concentration of 200 mg/kg with a writhing inhibition percentage of 62.5%, which did not reach tramadol's (89.3% ) but was similar to paracetamol's (45.5% ). Meanwhile, the anti-inflammatory effect of the 2% extract gel showed an inflammation inhibition percentage of 53.8%, which was similar to 1% dexamethasone and diclofenac. Conclusion: The evaluation of the hydroalcoholic extract from the leaves of Quararibea cordata (Bonpl.) Vischer, "Zapote," evidenced both an anti-inflammatory and analgesic effect in mice.