Examinando por Materia "Carragenina"

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    Anti-inflammatory effect of sacha inchi oil “Plukenetia volubilis linneo” in a model of inflammation with carragegenin in Balb/c mice, laboratory study – Lima 2022
    (Universidad Privada Norbert Wiener, 2024-07-16) Cachay Mercado, Nathalie Antonella; Ascanoa Olazo, Jimmy Antonio
    Objective: To determine the anti-inflammatory effect of Sacha Inchi oil "Plukenetia volubilis Linneo" in an inflammation model with Carrageenan in Balb/c mice, laboratory study – Lima 2022. Methodology: The research design was experimental. The sample consisted of 48 Balb/c mice, divided into 4 equal groups: a control group (A), Carrageenan group (B), Diclofenac group (C), and Sacha Inchi oil group (D). The inflammation models of plantar edema and air pouch were used by administering 0.1 mL of Carrageenan to the plantar aponeurosis and the skin of the back, respectively. Results: Sacha Inchi oil and Diclofenac reduced plantar edema at 1, 2, and 4 hours. However, Sacha Inchi achieved the greatest reduction at 24 hours with 0.44 (0.43-0.47) b, p<0.05 compared to the other groups. The C-reactive protein control on day 2 showed that Sacha Inchi oil at 2.80 (2.73-5.43) d,b had lower values than Diclofenac at 6.65 (6.50-6.95) c, with this difference being statistically significant. On day 5, Sacha Inchi had a median of 4.30 (3.4-5.2), which was lower than groups B and C (p<0.05). The leukocyte control on day 2 showed that Sacha Inchi had a mean of 21.5 ± 1.92, lower than groups B and C (p<0.05). On day 2, the levels of vasodilation were moderate, and on day 5, they were mild. Conclusion: It was demonstrated that Sacha Inchi oil "Plukenetia volubilis Linneo" has an anti-inflammatory effect in Balb/c mice.