Examinando por Materia "Cell Nucleus Shape"

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  • Miniatura
    ÍtemAcceso abierto
    Cellular descriptors in plasmacytes of bone marrow smears from patients with hematological neoplasia in the INEN – 2021
    (Universidad Privada Norbert Wiener, 2023-06-25) De La Cruz Solier, Ivonne Mercedes; Avelino Callupe, Paul Fortunato
    Cellular descriptors change the perspective of a hematology laboratory, enabling significant technological advances, ease of cellular recognition, and a larger morphological database. They also facilitate the reading of qualitative data by transforming it into quantitative, thus avoiding subjectivity between operators. This improves quality, time, and costs, offering a better outlook with enhanced education and training. The objective of this study is to analyze cellular descriptors in plasmacytes from bone marrow smears of patients with hematologic neoplasms at INEN in 2021. This study focuses on hematologic neoplasms, particularly plasma cell neoplasms, where plasmocytes proliferate and migrate to peripheral blood in advanced stages of the disease. Proper diagnosis in bone marrow smears is critical for timely intervention. Using our image database and cellular descriptors, plasmocytes will be described geometrically and colorimetrically.
  • Miniatura
    ÍtemAcceso abierto
    Cellular descriptors of megakaryocytes in the bone marrow of patients with hematological malignancies at the INEN - 2021
    (Universidad Privada Norbert Wiener, 2022-07-07) Valderrama Moreno, Mayra Consuelo; Avelino Callupe, Paul Fortunato
    Cellular morphological recognition plays an important role in hematology, allowing for presumptive diagnoses if there is any morphological alteration. This recognition is mainly done through optical microscopy; however, digital hematological analyzers allow for capturing and storing images of different cells, which are subsequently classified based on the cell descriptors, which are quantitative morphological characteristics. This project aims to determine the geometric and colorimetric descriptors of megakaryocytes, considered elements of hematopoiesis present in a bone marrow aspirate, which present variable morphological characteristics related to the presence of hematological neoplasms. The study will analyze 366 images of megakaryocytes from bone marrow aspirates of patients with hematological neoplasms using random sampling and the Fiji system to delimit the regions of interest of the cells to obtain each cellular descriptor. Finally, the results will be evaluated and compared with similar research.