Examinando por Materia "Chromatography, Thin Layer"

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    Determinación de una técnica selectiva por cromatografía en capa fina para identificación de benzodiacepinas. Diciembre 2017
    (Universidad Privada Norbert Wiener, 2018-12-05) Jiménez Martínez, Laura Mónica; Rodriguez Gariza, Yessica; Llahuilla Quea, José Antonio
    The consumption of benzodiazepines is closely related to medico-legal aspects, as it is associated with criminal acts such as theft, crimes against sexual integrity, doping, and, from a clinical-legal perspective, dependence. Objective: To determine a selective technique by Thin-Layer Chromatography (TLC) for the identification of benzodiazepines. Method: Thin-layer chromatography was employed as a selective identification technique for benzodiazepines. Urine samples were collected from 26 healthy volunteers who had previously been administered benzodiazepines. The analysis was conducted in the toxicology laboratories of Norbert Wiener University and the National University of San Marcos (UNMSM). Results: Thin-layer chromatography tested positive for benzodiazepines and other substances (phenobarbital and phenytoin) in 80% of the urine samples analyzed. It is suggested that confirmatory techniques, such as gas chromatography–mass spectrometry (GC-MS), be used. Conclusion: Thin-layer chromatography was determined to be a highly sensitive technique, but not specific for benzodiazepines.