Examinando por Materia "Clindamicina"

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    (Universidad Privada Norbert Wiener, 2018-03-05) Gutierrez Ortiz, Candy Genesis; Cupé Araujo, Ana Cecilia
    Objective: To determine the antimicrobial action of the triple antibiotic paste (TAP) and its modification with clindamycin at concentrations of 2 µg/ml, 1 µg/ml, 0.5 µg/ml, 0.25 µg/ml, 0.125 µg/ml against Enterococcus faecalis ATCC 29212 strain. Materials and methods: The Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) of the drugs comprising TAP (minocycline, metronidazole, and ciprofloxacin) and MTAP (clindamycin, metronidazole, and ciprofloxacin) were determined using the broth dilution method on E. faecalis strains at concentrations of 2 µg/ml, 1 µg/ml, 0.5 µg/ml, 0.25 µg/ml, and 0.125 µg/ml for each group. Results: Significant turbidity changes were observed for TAP at 2 µg/ml and 1 µg/ml, with the latter being the MIC. No bactericidal effects were observed at both concentrations. On the other hand, the MTAP group showed significant turbidity changes at all concentrations, except for the control group, with the MIC being 0.125 µg/ml and the MBC 0.5 µg/ml, respectively. Conclusions: Both combinations exhibited antimicrobial activity; however, MTAP demonstrated a minimum inhibitory concentration of 0.125 µg/ml and bactericidal concentration of 0.5 µg/ml, effectively inhibiting the growth of Enterococcus faecalis at low concentrations.