Examinando por Materia "Colecalciferol"

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Acceso abierto
Cholecalciferol supplementation to improve the bone-mineral status of hemodialysis patients
(Universidad Privada Norbert Wiener, 2022-11-10) Tupia Vargas, Elvis Miguel; León Cáceres, Johanna del Carmen
The present secondary research entitled as a critical review: Supplementation of cholecalciferol to improve the bone-mineral status of patients on hemodialysis, had the objective of: Knowing the benefit of supplementation with cholecalciferol in patients with Chronic Kidney Disease V on hemodialysis. The clinical question was: Will supplementation with cholecalciferol improve bone mineral status expressed in parathormone levels of men and women over 18 years of age with CKD V on hemodialysis? The Evidence-Based Nutrition (NuBE) methodology was used. The information search was carried out in PUBMED, SCIELO, DIALNET AND REDIB, finding 44 articles, 10 being selected that have been evaluated by the CASPE critical reading tool, finally selecting the Randomized Clinical Trial entitled Cholecalciferol in patients on hemodialysis: randomized study, double-blind, proof of concept and safety Cholecalciferol in hemodialysis patients: a randomized, double-blind, proof of concept and security which has a level of evidence B I and Grade of STRONG Recommendation, according to the expertise of the researcher. The critical comment allowed us to conclude that cholecalciferol is effective and safe, and does not negatively affect calcium, phosphorus, PTH levels or vascular calcifications.
Acceso abierto
Critical review: The effect of cholecalciferol supplementation improves vascular function in adult patients with chronic kidney disease.
(Universidad Privada Norbert Wiener, 2022-05-25) Ríos Barbarán, Martín; Dávila Córdova, Jennifer Estefania
Chronic kidney disease (CKD) is a public health problem of global relevance; since it is related to the increased risk of cardiovascular disease as kidney failure progresses, vitamin D deficiency is associated with mortality in patients with CKD, which could mitigate the risk of cardiovascular disease in CKD. The present secondary research entitled: Critical review: The effect of cholecalciferol supplementation improves vascular function in adult patients with chronic kidney disease", aimed to know the effect of cholecalciferol supplementation in improving vascular function in adult patients with chronic kidney disease. The clinical question was: Does the effect of cholecalciferol supplementation improve vascular function in adult patients with Chronic Kidney Disease? The Nutrition Based on Evidence (NuBE) methodology was used. The information search was performed in PUBMED and COCHRANE, finding 37 articles, of which 11 were selected and evaluated by the critical reading tool CASPE. Finally, the Randomized Clinical Trial entitled "A randomized trial of vitamin D supplementation on vascular function in CKD" was selected, which has an AI level of evidence and Strong Grade of Recommendation, according to the researcher's expertise. The critical commentary allowed to conclude that the use of cholecalciferol supplements improves vascular function through endothelial function indicators and circulating biomarkers, with cholecalciferol supplementation being considered as a nutritional treatment to positively improve in adult patients with chronic kidney disease; at the same time, it is proposed to continue carrying out clinical studies in which the number of participants is greater and the intervention period similar to the selected clinical trial.
Acceso abierto
Revisión crítica: impacto de los niveles de vitamina d en el paciente pediátrico con leucemia
(Universidad Privada Norbert Wiener, 2025-03-26) Escobedo Vara, Anderson Jose; Bohórquez Medina, Andrea Lisbet
La leucemia es una clase de cáncer que repercute en los glóbulos blancos y puede ser particularmente difícil de tratar en los pacientes de temprana edad. La suplementación con vitamina D ha tenido un impacto sobre los niveles sanguíneos de vitamina D en niños con leucemia. La investigación presente con título de revisión crítica: “Impacto de los niveles de vitamina D en pacientes pediátricos con leucemia” cuyo objetivo era realizar una apreciación crítica profesional fundamentada en el estudio de investigaciones científicas y estudios clínicos relacionados con entender la correlación entre los niveles de vitamina D y el progreso de la leucemia en niños. El interrogante del análisis clínico consistió en: ¿Cuál es el impacto de la vitamina D y su suplementación en niños con leucemia? La metodología de Nutrición Basada en Evidencia (NuBE) fue utilizada. La evaluación de la información se realizó en PUBMED, COCHRANE, SPRINGER, SCOPUS, OVED, SCIENCIE DIRECT, BASE (Bielefeld Academic Search Engine). Se lograron 32 artículos, de los cuales se escogieron 15 para ser evaluados mediante la realización de la lectura crítica CASPE. Finalmente, se eligió el metanálisis o revisión sistemática titulado “Are Pediatric Cancer Patients a Risk Group for Vitamin D Deficiency? A Systematic Review” que presenta rango de evidencia “AI” y Grado de Recomendación “Fuerte”, de acuerdo a la experiencia del investigador. El análisis crítico concluyó que la carencia de vitamina D es frecuente entre los pacientes pediátricos con leucemia. Aunque no hay estudios de gran magnitud que confirmen la efectividad de suplementar con vitamina D para mejorar los resultados en el tratamiento del cáncer, existe una elevación notable entre niveles adecuados de vitamina D y un pronóstico más optimista.